Insmed
INSM
677 hedge funds and large institutions have $37.8B invested in Insmed in 2025 Q4 according to their latest regulatory filings, with 201 funds opening new positions, 241 increasing their positions, 180 reducing their positions, and 81 closing their positions.
148% more first-time investments, than exits
New positions opened: 201 | Existing positions closed: 81
34% more repeat investments, than reductions
Existing positions increased: 241 | Existing positions reduced: 180
25% more capital invested
Capital invested by funds: $30.3B → $37.8B (+$7.51B)
20% more funds holding
Funds holding: 566 → 677 (+111)
2.16% more ownership
Funds ownership: 99.76% → 101.92% (+2.2%)
10% less call options, than puts
Call options by funds: $671M | Put options by funds: $741M
8% less funds holding in top 10
Funds holding in top 10: 24 → 22 (-2)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Invesco
Atlanta,
Georgia
|
+$1.01B |
| 2 |
BlackRock
New York
|
+$493M |
| 3 |
RI
RTW Investments
New York
|
+$321M |
| 4 |
State Street
Boston,
Massachusetts
|
+$222M |
| 5 |
Vanguard Group
Malvern,
Pennsylvania
|
+$208M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
T. Rowe Price Associates
Baltimore,
Maryland
|
-$528M |
| 2 |
Capital International Investors
Los Angeles,
California
|
-$438M |
| 3 |
D.E. Shaw & Co
New York
|
-$238M |
| 4 |
Qube Research & Technologies (QRT)
London,
United Kingdom
|
-$222M |
| 5 |
Millennium Management
New York
|
-$187M |
INSM Hedge Fund Activity: Q4 2025 in Review
677 of the 8,264 institutional investors tracked by Wall St. Rank reported a position in Insmed (INSM) for Q4 2025, worth a combined $37.8B — up 25% from $30.3B a quarter earlier.
Buyers outnumbered sellers: 201 funds opened new INSM positions and 81 closed out — a net gain of 120 holders — while 241 added to existing stakes and 180 trimmed.
The largest buyer was Invesco, adding an estimated $1.01B. The largest seller was T. Rowe Price Associates, cutting an estimated $528M.
- 677 institutional investors held Insmed (INSM) as of Q4 2025, up from 566 in Q3 2025.
- Funds reported $37.8B of Insmed stock for Q4 2025, up 25% quarter-over-quarter.
- 201 funds opened new Insmed positions in Q4 2025 and 81 closed out, a net change of +120 holders.
- The largest Insmed buyer in Q4 2025 was Invesco, an estimated $1.01B added.
- The largest Insmed seller in Q4 2025 was T. Rowe Price Associates, an estimated $528M sold.
Based on aggregated 13F filings for Q4 2025.