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Insmed
INSM

566 hedge funds and large institutions have $30.3B invested in Insmed in 2025 Q3 according to their latest regulatory filings, with 130 funds opening new positions, 194 increasing their positions, 197 reducing their positions, and 72 closing their positions.

New
Increased
Maintained
Reduced
Closed

81% more first-time investments, than exits

New positions opened: 130 | Existing positions closed: 72

43% more capital invested

Capital invested by funds: $21.2B → $30.3B (+$9.17B)

10% more funds holding

Funds holding: 516 → 566 (+50)

2% less repeat investments, than reductions

Existing positions increased: 194 | Existing positions reduced: 197

7% less call options, than puts

Call options by funds: $610M | Put options by funds: $657M

15.75% less ownership

Funds ownership: 115.51% → 99.76% (-16%)

27% less funds holding in top 10

Funds holding in top 10: 33 → 24 (-9)

Holders
566
Holders Change
+50
Holders Change %
+9.69%
% of All Funds
7.43%
Holding in Top 10
24
Holding in Top 10 Change
-9
Holding in Top 10 Change %
-27.27%
% of All Funds
0.32%
New
130
Increased
194
Reduced
197
Closed
72
Calls
$610M
Puts
$657M
Net Calls
-$47.7M
Net Calls Change
+$8.54M

Top Buyers

1
JP Morgan Chase
JP Morgan Chase
New York
+$908M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$501M
3
Vanguard Group
Vanguard Group
Pennsylvania
+$281M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$274M
5
OAG
Orbis Allan Gray
Bermuda
+$212M

Top Sellers

1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$527M
2
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$197M
3
DTC
Deep Track Capital
Connecticut
-$176M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$134M
5
BBA
Baker Bros. Advisors
New York
-$124M
Name Holding Trade Value Shares
Change 		Change in
Stake
JP Morgan Chase
1
JP Morgan Chase
New York
$3.32B +$908M +7,411,277 +47%
DGM
2
Darwin Global Management
Jersey
$2.9B +$136M +1,112,824 +6%
Vanguard Group
3
Vanguard Group
Pennsylvania
$2.87B +$281M +2,291,328 +13%
BlackRock
4
BlackRock
New York
$1.78B +$150M +1,222,472 +11%
Fidelity Investments
5
Fidelity Investments
Massachusetts
$1.32B +$501M +4,087,702 +80%
Capital International Investors
6
Capital International Investors
California
$1.09B +$9.19M +74,994 +1%
T. Rowe Price Associates
7
T. Rowe Price Associates
Maryland
$998M -$527M -4,299,239 -38%
BBA
8
Baker Bros. Advisors
New York
$965M -$124M -1,009,416 -13%
D.E. Shaw & Co
9
D.E. Shaw & Co
New York
$815M +$274M +2,234,845 +65%
Artisan Partners
10
Artisan Partners
Wisconsin
$711M +$199M +1,623,342 +49%
State Street
11
State Street
Massachusetts
$574M -$36M -293,534 -7%
Geode Capital Management
12
Geode Capital Management
Massachusetts
$542M +$51.3M +418,720 +13%
OAG
13
Orbis Allan Gray
Bermuda
$468M +$212M +1,726,734 +113%
RI
14
RTW Investments
New York
$444M – – –
Ameriprise
15
Ameriprise
Minnesota
$392M -$28.9M -236,094 -8%
DFO
16
Duquesne Family Office
New York
$349M +$20.8M +170,000 +8%
Millennium Management
17
Millennium Management
New York
$336M +$26.3M +214,395 +10%
Franklin Resources
18
Franklin Resources
California
$308M -$25.8M -210,408 -9%
Citadel Advisors
19
Citadel Advisors
Florida
$296M +$64.2M +524,364 +34%
Invesco
20
Invesco
Georgia
$289M +$13.2M +107,538 +6%
UBS Group
21
UBS Group
Switzerland
$237M +$166M +1,352,785 +461%
Bank of America
22
Bank of America
North Carolina
$231M +$45.9M +375,069 +31%
IHAM
23
Integral Health Asset Management
New York
$230M – – –
William Blair Investment Management
24
William Blair Investment Management
Illinois
$224M -$13.5M -110,545 -7%
Qube Research & Technologies (QRT)
25
Qube Research & Technologies (QRT)
United Kingdom
$222M +$56.6M +462,265 +43%
1
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INSM Hedge Fund Activity: Q3 2025 in Review

566 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Insmed (INSM) for Q3 2025, worth a combined $30.3B — up 43% from $21.2B a quarter earlier.

Buyers outnumbered sellers: 130 funds opened new INSM positions and 72 closed out — a net gain of 58 holders — while 194 added to existing stakes and 197 trimmed.

The largest buyer was JP Morgan Chase, adding an estimated $908M. The largest seller was T. Rowe Price Associates, cutting an estimated $527M.

  • 566 institutional investors held Insmed (INSM) as of Q3 2025, up from 516 in Q2 2025.
  • Funds reported $30.3B of Insmed stock for Q3 2025, up 43% quarter-over-quarter.
  • 130 funds opened new Insmed positions in Q3 2025 and 72 closed out, a net change of +58 holders.
  • The largest Insmed buyer in Q3 2025 was JP Morgan Chase, an estimated $908M added.
  • The largest Insmed seller in Q3 2025 was T. Rowe Price Associates, an estimated $527M sold.

Based on aggregated 13F filings for Q3 2025.