|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$85.4M
|
+$524K
|
+34,732
|
+0.6%
|
|
|
2
|
BVF Inc
San Francisco,
California
|
$31.4M
|
+$3.35M
|
+222,323
|
+12%
|
|
|
3
|
|
$28.1M
|
+$12.1M
|
+800,528
|
+79%
|
|
|
4
|
Perceptive Advisors
New York
|
$21.6M
|
-$2.11M
|
-140,278
|
-9%
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
$14.3M
|
+$1.52M
|
+100,607
|
+12%
|
|
|
6
|
EcoR1 Capital
San Francisco,
California
|
$12.3M
|
–
|
–
|
–
|
|
|
7
|
Deerfield Management
New York
|
$11.7M
|
-$2.81M
|
-186,611
|
-20%
|
|
|
8
|
Redmile Group
San Francisco,
California
|
$10.8M
|
+$249K
|
+16,500
|
+2%
|
|
|
9
|
Numeric Investors
Boston,
Massachusetts
|
$9.73M
|
+$9.46M
|
+627,770
|
New
|
|
|
10
|
Tekla Capital Management
Boston,
Massachusetts
|
$8.22M
|
–
|
–
|
–
|
|
|
11
|
Opaleye Management
Boston,
Massachusetts
|
$7.13M
|
+$1.81M
|
+120,000
|
+35%
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$6.91M
|
+$2.49M
|
+165,342
|
+59%
|
|
|
13
|
Renaissance Technologies
New York
|
$6.37M
|
+$2.65M
|
+176,100
|
+75%
|
|
|
14
|
Franklin Resources
San Mateo,
California
|
$5.17M
|
–
|
–
|
–
|
|
|
15
|
Northern Trust
Chicago,
Illinois
|
$4.91M
|
+$1.28M
|
+84,602
|
+36%
|
|
|
16
|
Driehaus Capital Management
Chicago,
Illinois
|
$4.5M
|
-$64.5K
|
-4,279
|
-1%
|
|
|
17
|
VHCP Management II
New York
|
$4.48M
|
–
|
–
|
–
|
|
|
18
|
|
$3.76M
|
+$859K
|
+56,972
|
+31%
|
|
|
19
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$3.76M
|
+$1.42M
|
+94,385
|
+64%
|
|
|
20
|
Spark Investment Management
New York
|
$3.67M
|
+$2.04M
|
+135,200
|
+133%
|
|
|
21
|
Geode Capital Management
Boston,
Massachusetts
|
$3.64M
|
+$393K
|
+26,053
|
+12%
|
|
|
22
|
Cormorant Asset Management
Boston,
Massachusetts
|
$3.56M
|
–
|
–
|
–
|
|
|
23
|
Sphera Funds Management
Tel Aviv,
Israel
|
$3.1M
|
+$754K
|
+50,000
|
+33%
|
|
|
24
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$3.02M
|
–
|
–
|
–
|
|
|
25
|
|
$2.75M
|
–
|
–
|
–
|
|
