|
1
|
Fidelity Investments
Boston,
Massachusetts
|
US$8544萬
|
+US$52.4萬
|
+34,732
|
+0.6%
|
|
|
2
|
BVF Inc
San Francisco,
California
|
US$3142萬
|
+US$335萬
|
+222,323
|
+12%
|
|
|
3
|
|
US$2809萬
|
+US$1207萬
|
+800,528
|
+79%
|
|
|
4
|
Perceptive Advisors
New York
|
US$2155萬
|
-US$211萬
|
-140,278
|
-9%
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
US$1432萬
|
+US$152萬
|
+100,607
|
+12%
|
|
|
6
|
EcoR1 Capital
San Francisco,
California
|
US$1232萬
|
–
|
–
|
–
|
|
|
7
|
Deerfield Management
New York
|
US$1173萬
|
-US$281萬
|
-186,611
|
-20%
|
|
|
8
|
Redmile Group
San Francisco,
California
|
US$1082萬
|
+US$24.9萬
|
+16,500
|
+2%
|
|
|
9
|
Numeric Investors
Boston,
Massachusetts
|
US$973萬
|
+US$946萬
|
+627,770
|
新
|
|
|
10
|
Tekla Capital Management
Boston,
Massachusetts
|
US$822萬
|
–
|
–
|
–
|
|
|
11
|
Opaleye Management
Boston,
Massachusetts
|
US$713萬
|
+US$181萬
|
+120,000
|
+35%
|
|
|
12
|
State Street
Boston,
Massachusetts
|
US$691萬
|
+US$249萬
|
+165,342
|
+59%
|
|
|
13
|
Renaissance Technologies
New York
|
US$637萬
|
+US$265萬
|
+176,100
|
+75%
|
|
|
14
|
Franklin Resources
San Mateo,
California
|
US$517萬
|
–
|
–
|
–
|
|
|
15
|
Northern Trust
Chicago,
Illinois
|
US$491萬
|
+US$128萬
|
+84,602
|
+36%
|
|
|
16
|
Driehaus Capital Management
Chicago,
Illinois
|
US$450萬
|
-US$6.45萬
|
-4,279
|
-1%
|
|
|
17
|
VHCP Management II
New York
|
US$448萬
|
–
|
–
|
–
|
|
|
18
|
|
US$376萬
|
+US$85.9萬
|
+56,972
|
+31%
|
|
|
19
|
T. Rowe Price Associates
Baltimore,
Maryland
|
US$376萬
|
+US$142萬
|
+94,385
|
+64%
|
|
|
20
|
Spark Investment Management
New York
|
US$367萬
|
+US$204萬
|
+135,200
|
+133%
|
|
|
21
|
Geode Capital Management
Boston,
Massachusetts
|
US$364萬
|
+US$39.3萬
|
+26,053
|
+12%
|
|
|
22
|
Cormorant Asset Management
Boston,
Massachusetts
|
US$356萬
|
–
|
–
|
–
|
|
|
23
|
Sphera Funds Management
Tel Aviv,
Israel
|
US$310萬
|
+US$75.4萬
|
+50,000
|
+33%
|
|
|
24
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
US$302萬
|
–
|
–
|
–
|
|
|
25
|
|
US$275萬
|
–
|
–
|
–
|
|
