|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$122M
|
+$4.79M
|
+231,189
|
+4%
|
|
|
2
|
TRV GP
Boston,
Massachusetts
|
$70.1M
|
+$68.8M
|
+3,320,348
|
New
|
|
|
3
|
|
$55.9M
|
+$12.2M
|
+586,698
|
+28%
|
|
|
4
|
Perceptive Advisors
New York
|
$52.6M
|
+$22.8M
|
+1,100,000
|
+79%
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
$25.4M
|
+$1.1M
|
+52,905
|
+5%
|
|
|
6
|
BVF Inc
San Francisco,
California
|
$23.7M
|
-$22.9M
|
-1,106,415
|
-50%
|
|
|
7
|
State Street
Boston,
Massachusetts
|
$23M
|
+$4.93M
|
+237,798
|
+28%
|
|
|
8
|
Millennium Management
New York
|
$17.7M
|
+$4.4M
|
+212,423
|
+34%
|
|
|
9
|
Deerfield Management
New York
|
$15.9M
|
-$72.6K
|
-3,500
|
-0.5%
|
|
|
10
|
Numeric Investors
Boston,
Massachusetts
|
$15.4M
|
+$4.02M
|
+194,000
|
+36%
|
|
|
11
|
Renaissance Technologies
New York
|
$15.1M
|
+$3.67M
|
+177,200
|
+33%
|
|
|
12
|
Pictet Asset Management (UK)
London,
United Kingdom
|
$12.4M
|
+$12.2M
|
+586,612
|
New
|
|
|
13
|
|
$10.8M
|
+$7.86M
|
+379,078
|
+283%
|
|
|
14
|
|
$9.66M
|
+$2.75M
|
+132,454
|
+41%
|
|
|
15
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$9.08M
|
+$2.49M
|
+120,004
|
+39%
|
|
|
16
|
Redmile Group
San Francisco,
California
|
$8.84M
|
+$755K
|
+36,409
|
+10%
|
|
|
17
|
Geode Capital Management
Boston,
Massachusetts
|
$7.33M
|
+$447K
|
+21,548
|
+7%
|
|
|
18
|
Franklin Resources
San Mateo,
California
|
$7.04M
|
–
|
–
|
–
|
|
|
19
|
Northern Trust
Chicago,
Illinois
|
$6.82M
|
-$131K
|
-6,329
|
-2%
|
|
|
20
|
Fidelity International
Hamilton,
Bermuda
|
$6.65M
|
+$4.15M
|
+200,058
|
+174%
|
|
|
21
|
American Century Companies
Kansas City,
Missouri
|
$6.5M
|
+$2.86M
|
+138,019
|
+81%
|
|
|
22
|
Tekla Capital Management
Boston,
Massachusetts
|
$5.59M
|
-$5.5M
|
-265,047
|
-50%
|
|
|
23
|
|
$5.14M
|
+$103K
|
+4,989
|
+2%
|
|
|
24
|
Spark Investment Management
New York
|
$5M
|
–
|
–
|
–
|
|
|
25
|
TIAA CREF Investment Management
New York
|
$4.48M
|
-$532K
|
-25,652
|
-11%
|
|
