|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$94.6M
|
+$229K
|
+17,375
|
+0.3%
|
|
|
2
|
BVF Inc
San Francisco,
California
|
$31.2M
|
+$16.4M
|
+1,249,869
|
+225%
|
|
|
3
|
Perceptive Advisors
New York
|
$26.4M
|
+$7.99M
|
+606,896
|
+66%
|
|
|
4
|
|
$17.5M
|
+$13.2M
|
+1,002,351
|
+10,405%
|
|
|
5
|
Deerfield Management
New York
|
$16.3M
|
–
|
–
|
–
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
$14.2M
|
+$362K
|
+27,532
|
+3%
|
|
|
7
|
EcoR1 Capital
San Francisco,
California
|
$13.7M
|
+$10.5M
|
+794,969
|
New
|
|
|
8
|
Redmile Group
San Francisco,
California
|
$11.8M
|
-$199K
|
-15,100
|
-2%
|
|
|
9
|
Tekla Capital Management
Boston,
Massachusetts
|
$9.15M
|
-$2.97M
|
-225,998
|
-30%
|
|
|
10
|
Opaleye Management
Boston,
Massachusetts
|
$5.87M
|
+$2.24M
|
+170,000
|
+100%
|
|
|
11
|
Franklin Resources
San Mateo,
California
|
$5.76M
|
–
|
–
|
–
|
|
|
12
|
Driehaus Capital Management
Chicago,
Illinois
|
$5.09M
|
+$3.88M
|
+294,694
|
New
|
|
|
13
|
VHCP Management II
New York
|
$4.99M
|
-$3.8M
|
-288,916
|
-50%
|
|
|
14
|
State Street
Boston,
Massachusetts
|
$4.85M
|
+$72.3K
|
+5,490
|
+2%
|
|
|
15
|
Renaissance Technologies
New York
|
$4.05M
|
+$1.89M
|
+143,600
|
+157%
|
|
|
16
|
Northern Trust
Chicago,
Illinois
|
$4.01M
|
-$33.2K
|
-2,522
|
-1%
|
|
|
17
|
Cormorant Asset Management
Boston,
Massachusetts
|
$3.97M
|
-$1.86M
|
-141,636
|
-38%
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
$3.6M
|
+$224K
|
+16,991
|
+9%
|
|
|
19
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$3.37M
|
+$526K
|
+40,000
|
+26%
|
|
|
20
|
Private Advisor Group
Morristown,
New Jersey
|
$3.36M
|
-$211K
|
-16,000
|
-8%
|
|
|
21
|
|
$3.21M
|
+$2.07M
|
+157,261
|
+551%
|
|
|
22
|
|
$3.06M
|
+$658K
|
+50,000
|
+39%
|
|
|
23
|
Millennium Management
New York
|
$2.9M
|
+$1.5M
|
+114,220
|
+214%
|
|
|
24
|
Eventide Asset Management
Boston,
Massachusetts
|
$2.59M
|
–
|
–
|
–
|
|
|
25
|
Sphera Funds Management
Tel Aviv,
Israel
|
$2.59M
|
+$1.97M
|
+150,000
|
New
|
|
