|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$100M
|
+$275K
|
+17,646
|
+0.3%
|
|
|
2
|
BVF Inc
San Francisco,
California
|
$40.5M
|
+$3.18M
|
+203,900
|
+10%
|
|
|
3
|
|
$37.4M
|
+$3.86M
|
+247,389
|
+14%
|
|
|
4
|
Perceptive Advisors
New York
|
$25.3M
|
–
|
–
|
–
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
$20.9M
|
+$3.5M
|
+224,068
|
+24%
|
|
|
6
|
State Street
Boston,
Massachusetts
|
$15.5M
|
+$6.36M
|
+407,703
|
+91%
|
|
|
7
|
EcoR1 Capital
San Francisco,
California
|
$15.1M
|
+$543K
|
+34,802
|
+4%
|
|
|
8
|
Deerfield Management
New York
|
$13.8M
|
–
|
–
|
–
|
|
|
9
|
Millennium Management
New York
|
$11.4M
|
+$8.15M
|
+522,495
|
+510%
|
|
|
10
|
Renaissance Technologies
New York
|
$9.77M
|
+$1.98M
|
+127,000
|
+31%
|
|
|
11
|
Numeric Investors
Boston,
Massachusetts
|
$9.72M
|
-$1.45M
|
-92,905
|
-15%
|
|
|
12
|
Tekla Capital Management
Boston,
Massachusetts
|
$9.63M
|
–
|
–
|
–
|
|
|
13
|
Opaleye Management
Boston,
Massachusetts
|
$8.18M
|
-$156K
|
-10,000
|
-2%
|
|
|
14
|
Redmile Group
San Francisco,
California
|
$6.95M
|
-$4.93M
|
-316,121
|
-45%
|
|
|
15
|
Franklin Resources
San Mateo,
California
|
$6.06M
|
–
|
–
|
–
|
|
|
16
|
Northern Trust
Chicago,
Illinois
|
$5.99M
|
+$202K
|
+12,925
|
+4%
|
|
|
17
|
Geode Capital Management
Boston,
Massachusetts
|
$5.92M
|
+$1.42M
|
+91,162
|
+39%
|
|
|
18
|
|
$5.91M
|
+$3.08M
|
+197,389
|
+154%
|
|
|
19
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$5.63M
|
+$1.05M
|
+67,393
|
+28%
|
|
|
20
|
TIAA CREF Investment Management
New York
|
$4.32M
|
+$1.06M
|
+68,147
|
+40%
|
|
|
21
|
|
$4.31M
|
-$65.5K
|
-4,200
|
-2%
|
|
|
22
|
Spark Investment Management
New York
|
$4.3M
|
–
|
–
|
–
|
|
|
23
|
Sphera Funds Management
Tel Aviv,
Israel
|
$3.82M
|
+$156K
|
+10,000
|
+5%
|
|
|
24
|
Private Advisor Group
Morristown,
New Jersey
|
$3.66M
|
+$1.33M
|
+85,187
|
+85%
|
|
|
25
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$3.6M
|
+$1.45M
|
+93,048
|
+88%
|
|
