|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$60M
|
+$207K
|
+17,090
|
+0.3%
|
|
|
2
|
Putnam Investments
Boston,
Massachusetts
|
$15M
|
-$64.3K
|
-5,309
|
-0.4%
|
|
|
3
|
Deerfield Management
New York
|
$10.4M
|
–
|
–
|
–
|
|
|
4
|
Perceptive Advisors
New York
|
$10.2M
|
+$11.2M
|
+923,763
|
New
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
$8.75M
|
+$138K
|
+11,353
|
+1%
|
|
|
6
|
Tekla Capital Management
Boston,
Massachusetts
|
$8.31M
|
–
|
–
|
–
|
|
|
7
|
Redmile Group
San Francisco,
California
|
$7.66M
|
-$214K
|
-17,700
|
-2%
|
|
|
8
|
BlackRock Fund Advisors
San Francisco,
California
|
$7.13M
|
+$1.1M
|
+91,073
|
+16%
|
|
|
9
|
VHCP Management II
New York
|
$6.35M
|
–
|
–
|
–
|
|
|
10
|
BVF Inc
San Francisco,
California
|
$6.1M
|
-$448K
|
-37,007
|
-6%
|
|
|
11
|
Cormorant Asset Management
Boston,
Massachusetts
|
$4.08M
|
–
|
–
|
–
|
|
|
12
|
Franklin Resources
San Mateo,
California
|
$3.67M
|
–
|
–
|
–
|
|
|
13
|
State Street
Boston,
Massachusetts
|
$3.03M
|
+$55.7K
|
+4,596
|
+2%
|
|
|
14
|
Northern Trust
Chicago,
Illinois
|
$2.58M
|
+$220K
|
+18,182
|
+8%
|
|
|
15
|
Private Advisor Group
Morristown,
New Jersey
|
$2.36M
|
+$12K
|
+988
|
+0.5%
|
|
|
16
|
BlackRock Institutional Trust
San Francisco,
California
|
$2.24M
|
+$376K
|
+31,032
|
+18%
|
|
|
17
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$2.21M
|
+$2.44M
|
+201,203
|
New
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
$2.11M
|
+$134K
|
+11,058
|
+6%
|
|
|
19
|
Opaleye Management
Boston,
Massachusetts
|
$1.87M
|
+$121K
|
+10,000
|
+6%
|
|
|
20
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$1.7M
|
–
|
–
|
–
|
|
|
21
|
Eventide Asset Management
Boston,
Massachusetts
|
$1.65M
|
–
|
–
|
–
|
|
|
22
|
Montecito Bank & Trust
Santa Barbara,
California
|
$1.61M
|
–
|
–
|
–
|
|
|
23
|
|
$1.4M
|
–
|
–
|
–
|
|
|
24
|
Bank of America
Charlotte,
North Carolina
|
$1.3M
|
+$565K
|
+46,666
|
+65%
|
|
|
25
|
Charles Schwab
San Francisco,
California
|
$1.05M
|
+$290K
|
+23,966
|
+34%
|
|
