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Alnylam Pharmaceuticals
ALNY

Overview Fund Activity

646 hedge funds and large institutions have $43B invested in Alnylam Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 97 funds opening new positions, 257 increasing their positions, 214 reducing their positions, and 62 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
646
Holders Change
+29
Holders Change %
+4.7%
% of All Funds
8.66%
Holding in Top 10
9
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-10%
% of All Funds
0.12%
New
97
Increased
257
Reduced
214
Closed
62
Calls
$188M
Puts
$203M
Net Calls
-$15.5M
Net Calls Change
-$50.8M

Top Buyers

1
Citadel Advisors
Citadel Advisors
Florida
+$195M
2
Holocene Advisors
Holocene Advisors
New York
+$195M
3
ClearBridge Investments
ClearBridge Investments
New York
+$179M
4
Macquarie Group
Macquarie Group
Australia
+$172M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$162M

Top Sellers

1
AQR Capital Management
AQR Capital Management
Connecticut
-$208M
2
Baillie Gifford & Co
Baillie Gifford & Co
United Kingdom
-$204M
3
Wellington Management Group
Wellington Management Group
Massachusetts
-$175M
4
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$117M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
-$89.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
KRSITF
326
Kentucky Retirement Systems Insurance Trust Fund
Kentucky
$1.14M -$79.2K -243 -6%
DILIC
327
Dai-ichi Life Insurance Company
Japan
$1.13M +$815K +2,500 +262%
IWC
328
Integrated Wealth Concepts
Massachusetts
$1.12M +$230K +706 +26%
SPAS
329
Spectrum Planning & Advisory Services
California
$1.1M – – –
SAM
330
Sectoral Asset Management
Quebec, Canada
$1.08M -$614K -1,882 -36%
GFM
331
GF Fund Management
China
$1.08M – – –
LJHT
332
Laurie J. Hall Trustee
$1.06M – – –
OCM
333
Orion Capital Management
California
$1.06M -$32.6K -100 -3%
BMSSC
334
B. Metzler seel. Sohn & Co
Germany
$1.05M – – –
GCM
335
Graham Capital Management
Connecticut
$1.03M +$404K +1,240 +65%
Focus Partners Wealth
336
Focus Partners Wealth
Massachusetts
$1.03M -$348K -1,068 -25%
GD
337
Grandfield & Dodd
New York
$995K +$6.52K +20 +0.7%
CPBTD
338
Central Pacific Bank - Trust Division
Hawaii
$984K +$119K +365 +14%
MFS
339
Mirabella Financial Services
United Kingdom
$973K -$2.87M -8,767 -75%
ECM
340
Everence Capital Management
Indiana
$968K – – –
CFO
341
Callan Family Office
Pennsylvania
$956K +$624K +1,913 +188%
Vontobel Holding
342
Vontobel Holding
Switzerland
$951K +$400K +1,226 +73%
RIA
343
Regal Investment Advisors
Michigan
$948K – – –
GIC
344
Generali Investments CEE
Czech Republic
$946K – – –
EF
345
Empowered Funds
Pennsylvania
$930K -$994K -3,048 -52%
VI
346
Vestcor Inc
New Brunswick, Canada
$925K +$122K +375 +15%
STA
347
Summit Trail Advisors
New York
$916K +$328K +1,006 +56%
SW
348
SteelPeak Wealth
California
$916K +$26.4K +81 +3%
ETC
349
Exchange Traded Concepts
Oklahoma
$915K -$296K -909 -24%
HKAM
350
Horizon Kinetics Asset Management
New York
$900K -$39.5K -121 -4%
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