Vanguard Portfolio Management
UPB

Vanguard Portfolio Management’s Upstream Bio Inc UPB Stock Holding History

Vanguard Portfolio Management’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$4.93M Sell
712,667
-15,044
-2% -$126K ﹤0.01% 2446
2026
Q1 		$6.55M Buy
+727,711
New +$13.1M ﹤0.01% 2242

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Vanguard Portfolio Management's UPB Position: Q2 2026 in Review

Vanguard Portfolio Management reduced its Upstream Bio Inc (UPB) stake by 2.1% in Q2 2026, selling an estimated $126K and leaving 712,667 shares worth $4.93M. The position accounts for ﹤0.01% of the portfolio, ranked #2446.

Vanguard Portfolio Management first reported a position in UPB in Q1 2026 and has held it in 2 quarters since. The position peaked at $6.55M in Q1 2026. 149 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Vanguard Portfolio Management held 712,667 shares of Upstream Bio Inc worth $4.93M as of Q2 2026.
  • Vanguard Portfolio Management sold 15,044 Upstream Bio Inc shares in Q2 2026, an estimated $126K.
  • Upstream Bio Inc made up ﹤0.01% of Vanguard Portfolio Management's portfolio in Q2 2026, its #2446 holding.
  • Vanguard Portfolio Management first reported a position in Upstream Bio Inc in Q1 2026 and has held it in 2 quarters since.
  • Vanguard Portfolio Management's Upstream Bio Inc position peaked at $6.55M in Q1 2026.
  • 149 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Vanguard Portfolio Management's 13F filing for Q2 2026, filed 13 Aug 2026.