Two Sigma Investments
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Two Sigma Investments’s Guardant Health GH Stock Holding History

Two Sigma Investments’s Portfolio GH Stock Details GH Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$391M Buy
4,229,531
+2,057,628
+95% +$207M 0.32% 56
2025
Q4 		$222M Buy
2,171,903
+368,572
+20% +$33M 0.31% 49
2025
Q3 		$113M Sell
1,803,331
-51,280
-3% -$2.79M 0.17% 164
2025
Q2 		$96.5M Buy
1,854,611
+28,748
+2% +$1.28M 0.17% 163
2025
Q1 		$77.8M Sell
1,825,863
-64,851
-3% -$2.8M 0.17% 151
2024
Q4 		$57.8M Buy
1,890,714
+525,368
+38% +$14.8M 0.13% 201
2024
Q3 		$31.3M Buy
1,365,346
+550,823
+68% +$15.6M 0.07% 354
2024
Q2 		$23.5M Buy
814,523
+563,595
+225% +$13.1M 0.05% 409
2024
Q1 		$5.18M Sell
250,928
-333,629
-57% -$7.15M 0.01% 948
2023
Q4 		$15.8M Sell
584,557
-517,316
-47% -$13.6M 0.04% 496
2023
Q3 		$32.7M Buy
1,101,873
+83,825
+8% +$2.95M 0.09% 270
2023
Q2 		$36.4M Buy
1,018,048
+231,591
+29% +$6.65M 0.09% 269
2023
Q1 		$18.4M Buy
786,457
+299,037
+61% +$8.54M 0.05% 397
2022
Q4 		$13.3M Buy
487,420
+307,821
+171% +$14.1M 0.04% 467
2022
Q3 		$9.67M Sell
179,599
-52,217
-23% -$2.68M 0.03% 500
2022
Q2 		$9.35M Buy
+231,816
New +$11.5M 0.03% 541
2021
Q4 		– Sell
-2,200
Closed -$228K – 4492
2021
Q3 		$275K Sell
2,200
-140,281
-98% -$16.7M ﹤0.01% 3736
2021
Q2 		$17.7M Buy
142,481
+21,525
+18% +$2.9M 0.04% 537
2021
Q1 		$18.5M Buy
120,956
+118,200
+4,289% +$17.9M 0.05% 470
2020
Q4 		$355K Buy
+2,756
New +$317K ﹤0.01% 2740
2019
Q4 		– Sell
-34,332
Closed -$2.47M – 3760
2019
Q3 		$2.19M Buy
+34,332
New +$3.02M 0.01% 1361

Other funds holding GH

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Invesco
Invesco Atlanta, Georgia $1.02T AUM 30.18% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
Baillie Gifford & Co
Baillie Gifford & Co Edinburgh, United Kingdom $97.9B AUM 20.73% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Capital International Investors
Capital International Investors Los Angeles, California $427B AUM 29.17% 1-Year Est. Return

Two Sigma Investments's GH Position: Q1 2026 in Review

Two Sigma Investments increased its Guardant Health (GH) stake by 95% in Q1 2026, buying an estimated $207M and bringing the position to 4,229,531 shares worth $391M. The position accounts for 0.32% of the portfolio, ranked #56.

Two Sigma Investments first reported a position in GH in Q3 2019 and has held it in 21 quarters since. 481 funds tracked by Wall St. Rank hold GH as of Q1 2026.

  • Two Sigma Investments held 4,229,531 shares of Guardant Health worth $391M as of Q1 2026.
  • Two Sigma Investments bought 2,057,628 Guardant Health shares in Q1 2026, an estimated $207M.
  • Guardant Health made up 0.32% of Two Sigma Investments's portfolio in Q1 2026, its #56 holding.
  • Two Sigma Investments first reported a position in Guardant Health in Q3 2019 and has held it in 21 quarters since.
  • 481 funds tracked by Wall St. Rank held Guardant Health as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.