Guardant Health
497 hedge funds and large institutions have $13.4B invested in Guardant Health in 2025 Q4 according to their latest regulatory filings, with 141 funds opening new positions, 155 increasing their positions, 149 reducing their positions, and 33 closing their positions.
327% more first-time investments, than exits
New positions opened: 141 | Existing positions closed: 33
90% more call options, than puts
Call options by funds: $243M | Put options by funds: $128M
75% more capital invested
Capital invested by funds: $7.65B → $13.4B (+$5.73B)
44% more funds holding in top 10
Funds holding in top 10: 9 → 13 (+4)
26% more funds holding
Funds holding: 395 → 497 (+102)
5.75% more ownership
Funds ownership: 98.24% → 103.99% (+5.8%)
4% more repeat investments, than reductions
Existing positions increased: 155 | Existing positions reduced: 149
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
AllianceBernstein
Nashville,
Tennessee
|
+$158M |
| 2 |
Fidelity Investments
Boston,
Massachusetts
|
+$141M |
| 3 |
T. Rowe Price Associates
Baltimore,
Maryland
|
+$127M |
| 4 |
Point72 Asset Management
Stamford,
Connecticut
|
+$125M |
| 5 |
Goldman Sachs
New York
|
+$100M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Wellington Management Group
Boston,
Massachusetts
|
-$254M |
| 2 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
-$121M |
| 3 |
CCM
Cadian Capital Management
New York
|
-$109M |
| 4 |
Capital International Investors
Los Angeles,
California
|
-$104M |
| 5 |
EAM
Eventide Asset Management
Boston,
Massachusetts
|
-$72.5M |
GH Hedge Fund Activity: Q4 2025 in Review
497 institutional investors reported a position in Guardant Health (GH) for Q4 2025, worth a combined $13.4B — up 75% from $7.65B a quarter earlier.
Buyers outnumbered sellers: 141 funds opened new GH positions and 33 closed out — a net gain of 108 holders — while 155 added to existing stakes and 149 trimmed.
The largest buyer was AllianceBernstein, adding an estimated $158M. The largest seller was Wellington Management Group, cutting an estimated $254M.
- 497 institutional investors held Guardant Health (GH) as of Q4 2025, up from 395 in Q3 2025.
- Funds reported $13.4B of Guardant Health stock for Q4 2025, up 75% quarter-over-quarter.
- 141 funds opened new Guardant Health positions in Q4 2025 and 33 closed out, a net change of +108 holders.
- The largest Guardant Health buyer in Q4 2025 was AllianceBernstein, an estimated $158M added.
- The largest Guardant Health seller in Q4 2025 was Wellington Management Group, an estimated $254M sold.
Based on aggregated 13F filings for Q4 2025.