Two Sigma Advisers
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Two Sigma Advisers’s uniQure QURE Stock Holding History

Two Sigma Advisers’s Portfolio QURE Stock Details QURE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-1,110,400
Closed -$26.6M – 1657
2025
Q4 		$26.6M Buy
1,110,400
+700,900
+171% +$27M 0.05% 285
2025
Q3 		$23.9M Sell
409,500
-250,200
-38% -$4.54M 0.05% 285
2025
Q2 		$9.2M Sell
659,700
-8,794
-1% -$118K 0.02% 537
2025
Q1 		$7.09M Sell
668,494
-88,406
-12% -$1.24M 0.02% 646
2024
Q4 		$13.4M Buy
756,900
+10,400
+1% +$89.8K 0.03% 411
2024
Q3 		$3.68M Buy
746,500
+531,800
+248% +$3.46M 0.01% 817
2024
Q2 		$962K Sell
214,700
-74,800
-26% -$364K ﹤0.01% 1569
2024
Q1 		$1.51M Buy
289,500
+261,200
+923% +$1.5M ﹤0.01% 1369
2023
Q4 		$192K Buy
+28,300
New +$187K ﹤0.01% 2239
2021
Q2 		– Sell
-50,700
Closed -$1.71M – 2647
2021
Q1 		$1.71M Sell
50,700
-37,100
-42% -$1.33M ﹤0.01% 1351
2020
Q4 		$3.17M Sell
87,800
-26,400
-23% -$1.11M 0.01% 1028
2020
Q3 		$4.21M Buy
114,200
+88,000
+336% +$3.61M 0.01% 828
2020
Q2 		$1.18M Sell
26,200
-47,800
-65% -$2.82M ﹤0.01% 1499
2020
Q1 		$3.51M Sell
74,000
-107,300
-59% -$6.17M 0.01% 855
2019
Q4 		$13M Sell
181,300
-8,000
-4% -$439K 0.03% 506
2019
Q3 		$7.45M Buy
189,300
+160,800
+564% +$9.28M 0.02% 634
2019
Q2 		$2.23M Buy
28,500
+21,400
+301% +$1.36M 0.01% 1158
2019
Q1 		$424K Sell
7,100
-7,100
-50% -$317K ﹤0.01% 1857
2018
Q4 		$409K Sell
14,200
-3,500
-20% -$97.4K ﹤0.01% 1850
2018
Q3 		$644K Sell
17,700
-8,000
-31% -$298K ﹤0.01% 1701
2018
Q2 		$971K Buy
25,700
+5,600
+28% +$179K ﹤0.01% 1616
2018
Q1 		$472K Sell
20,100
-4,200
-17% -$91.6K ﹤0.01% 1837
2017
Q4 		$476K Buy
+24,300
New +$370K ﹤0.01% 1785

Other funds holding QURE

ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
Aberdeen Group
Aberdeen Group Edinburgh, United Kingdom $71.2B AUM 41.74% 1-Year Est. Return
Two Sigma Investments
Two Sigma Investments New York $138B AUM 41.87% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
MB
MPM BioImpact Boston, Massachusetts $1.64B AUM 245.64% 1-Year Est. Return

Two Sigma Advisers's QURE Position: Q1 2026 in Review

Two Sigma Advisers sold out of uniQure (QURE) in Q1 2026, closing a stake of 1,110,400 shares — an estimated $26.6M sold.

Two Sigma Advisers first reported a position in QURE in Q4 2017 and held it in 23 quarters. The position peaked at $26.6M in Q4 2025. 213 funds tracked by Wall St. Rank hold QURE as of Q1 2026.

  • Two Sigma Advisers reported no remaining uniQure position as of Q1 2026 after selling out during the quarter.
  • Two Sigma Advisers sold 1,110,400 uniQure shares in Q1 2026, an estimated $26.6M.
  • Two Sigma Advisers first reported a position in uniQure in Q4 2017 and held it in 23 quarters.
  • Two Sigma Advisers's uniQure position peaked at $26.6M in Q4 2025.
  • 213 funds tracked by Wall St. Rank held uniQure as of Q1 2026.

Based on Two Sigma Advisers's 13F filing for Q1 2026.