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uniQure

141 hedge funds and large institutions have $533M invested in uniQure in 2025 Q1 according to their latest regulatory filings, with 24 funds opening new positions, 53 increasing their positions, 37 reducing their positions, and 20 closing their positions.

New
Increased
Maintained
Reduced
Closed

307% more call options, than puts

Call options by funds: $22.9M | Put options by funds: $5.62M

43% more repeat investments, than reductions

Existing positions increased: 53 | Existing positions reduced: 37

20% more first-time investments, than exits

New positions opened: 24 | Existing positions closed: 20

7.08% more ownership

Funds ownership: 85.53%92.61% (+7.1%)

2% more funds holding

Funds holding: 138141 (+3)

28% less capital invested

Capital invested by funds: $736M → $533M (-$203M)

50% less funds holding in top 10

Funds holding in top 10: 63 (-3)

Holders
141
Holders Change
+3
Holders Change %
+2.17%
% of All Funds
1.89%
Holding in Top 10
3
Holding in Top 10 Change
-3
Holding in Top 10 Change %
-50%
% of All Funds
0.04%
New
24
Increased
53
Reduced
37
Closed
20
Calls
$22.9M
Puts
$5.62M
Net Calls
+$17.3M
Net Calls Change
-$21.1M
Name Holding Trade Value Shares
Change
Change in
Stake
VPC
1
Vestal Point Capital
New York
$50.8M +$24.8M +1,767,572 +58%
RI
2
RTW Investments
New York
$45.2M +$47.1M +3,361,803 +372%
EC
3
EcoR1 Capital
California
$42.3M +$8.26M +588,971 +17%
NCM
4
Nantahala Capital Management
Connecticut
$29.2M +$4.24M +302,598 +12%
Aberdeen Group
5
Aberdeen Group
United Kingdom
$23.5M +$9.9M +706,216 +47%
ACA
6
Avoro Capital Advisors
New York
$23.1M
Franklin Resources
7
Franklin Resources
California
$21.1M
6CM
8
683 Capital Management
New York
$16.4M +$351K +25,000 +2%
BlackRock
9
BlackRock
New York
$15.2M +$300K +21,423 +2%
Schroder Investment Management Group
10
Schroder Investment Management Group
United Kingdom
$14.8M +$4.99M +356,046 +43%
IHAM
11
Integral Health Asset Management
New York
$13.3M +$2.1M +150,000 +14%
State Street
12
State Street
Massachusetts
$13M +$14.5M +1,037,056 +539%
Fidelity Investments
13
Fidelity Investments
Massachusetts
$12.7M +$3.29M +234,294 +24%
Vanguard Group
14
Vanguard Group
Pennsylvania
$10M -$2.26M -161,135 -15%
Two Sigma Investments
15
Two Sigma Investments
New York
$9.71M +$527K +37,615 +4%
CCM
16
Catalio Capital Management
New York
$8.8M -$1M -71,648 -8%
Citadel Advisors
17
Citadel Advisors
Florida
$8.32M +$10.8M +773,314 +6,441%
BCM
18
Boxer Capital Management
California
$7.95M
SC
19
Stempoint Capital
New York
$7.75M +$8.99M +641,039 +712%
Macquarie Group
20
Macquarie Group
Australia
$7.49M
Two Sigma Advisers
21
Two Sigma Advisers
New York
$7.09M -$1.24M -88,406 -12%
Geode Capital Management
22
Geode Capital Management
Massachusetts
$6.48M +$1.27M +90,418 +17%
Morgan Stanley
23
Morgan Stanley
New York
$6.4M -$1.32M -93,808 -13%
PHS
24
PFM Health Sciences
California
$6.36M +$4.44M +316,809 +112%
PFM
25
Privium Fund Management
Netherlands
$6.14M -$2.29M -163,023 -22%

QURE Hedge Fund Activity: Q1 2025 in Review

141 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in uniQure (QURE) for Q1 2025, worth a combined $533M — down 28% from $736M a quarter earlier.

Buyers outnumbered sellers: 24 funds opened new QURE positions and 20 closed out — a net gain of 4 holders — while 53 added to existing stakes and 37 trimmed.

The largest buyer was RTW Investments, adding an estimated $47.1M. The largest seller was Point72 Asset Management, cutting an estimated $23M.

  • 141 institutional investors held uniQure (QURE) as of Q1 2025, up from 138 in Q4 2024.
  • Funds reported $533M of uniQure stock for Q1 2025, down 28% quarter-over-quarter.
  • 24 funds opened new uniQure positions in Q1 2025 and 20 closed out, a net change of +4 holders.
  • The largest uniQure buyer in Q1 2025 was RTW Investments, an estimated $47.1M added.
  • The largest uniQure seller in Q1 2025 was Point72 Asset Management, an estimated $23M sold.

Based on aggregated 13F filings for Q1 2025.