State Street
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State Street’s Amylyx Pharmaceuticals AMLX Stock Holding History

State Street’s Portfolio AMLX Stock Details AMLX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$32.8M Buy
2,363,161
+293,277
+14% +$4.13M ﹤0.01% 1963
2025
Q4 		$25M Buy
2,069,884
+448,624
+28% +$6.09M ﹤0.01% 2137
2025
Q3 		$22M Buy
1,621,260
+612,351
+61% +$5.76M ﹤0.01% 2187
2025
Q2 		$6.47M Buy
1,008,909
+747,126
+285% +$3.63M ﹤0.01% 2824
2025
Q1 		$927K Buy
261,783
+43,400
+20% +$154K ﹤0.01% 3444
2024
Q4 		$825K Buy
218,383
+63,475
+41% +$299K ﹤0.01% 3522
2024
Q3 		$502K Hold
154,908
– – ﹤0.01% 3595
2024
Q2 		$294K Sell
154,908
-1,905,134
-92% -$3.69M ﹤0.01% 3706
2024
Q1 		$5.85M Buy
2,060,042
+618,640
+43% +$8.09M ﹤0.01% 2862
2023
Q4 		$21.2M Buy
1,441,402
+201,649
+16% +$3.09M ﹤0.01% 2178
2023
Q3 		$22.7M Buy
1,239,753
+82,054
+7% +$1.74M ﹤0.01% 2102
2023
Q2 		$25M Buy
1,157,699
+91,461
+9% +$2.47M ﹤0.01% 2107
2023
Q1 		$31.3M Sell
1,066,238
-9,374
-0.9% -$326K ﹤0.01% 1943
2022
Q4 		$39.7M Buy
1,075,612
+248,544
+30% +$8.82M ﹤0.01% 1788
2022
Q3 		$23.3M Buy
827,068
+630,603
+321% +$15.7M ﹤0.01% 2109
2022
Q2 		$3.78M Buy
196,465
+97,253
+98% +$1.15M ﹤0.01% 3236
2022
Q1 		$1.27M Buy
+99,212
New +$2.24M ﹤0.01% 3730

Other funds holding AMLX

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $3.5B AUM 1,165.83% 1-Year Est. Return
CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
SVCM
Saturn V Capital Management Austin, Texas $552M AUM 551.78% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return
FLAM
First Light Asset Management Edina, Minnesota $1.12B AUM 114.45% 1-Year Est. Return

State Street's AMLX Position: Q1 2026 in Review

State Street increased its Amylyx Pharmaceuticals (AMLX) stake by 14% in Q1 2026, buying an estimated $4.13M and bringing the position to 2,363,161 shares worth $32.8M. The position accounts for ﹤0.01% of the portfolio, ranked #1963.

State Street first reported a position in AMLX in Q1 2022 and has held it in 17 quarters since. The position peaked at $39.7M in Q4 2022. 171 funds tracked by Wall St. Rank hold AMLX as of Q1 2026.

  • State Street held 2,363,161 shares of Amylyx Pharmaceuticals worth $32.8M as of Q1 2026.
  • State Street bought 293,277 Amylyx Pharmaceuticals shares in Q1 2026, an estimated $4.13M.
  • Amylyx Pharmaceuticals made up ﹤0.01% of State Street's portfolio in Q1 2026, its #1963 holding.
  • State Street first reported a position in Amylyx Pharmaceuticals in Q1 2022 and has held it in 17 quarters since.
  • State Street's Amylyx Pharmaceuticals position peaked at $39.7M in Q4 2022.
  • 171 funds tracked by Wall St. Rank held Amylyx Pharmaceuticals as of Q1 2026.

Based on State Street's 13F filing for Q1 2026, filed 15 May 2026.