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Amylyx Pharmaceuticals

122 hedge funds and large institutions have $188M invested in Amylyx Pharmaceuticals in 2024 Q4 according to their latest regulatory filings, with 33 funds opening new positions, 35 increasing their positions, 40 reducing their positions, and 20 closing their positions.

New
Increased
Maintained
Reduced
Closed

65% more first-time investments, than exits

New positions opened: 33 | Existing positions closed: 20

34% more capital invested

Capital invested by funds: $141M → $188M (+$47.6M)

11% more funds holding

Funds holding: 110122 (+12)

8.85% more ownership

Funds ownership: 63.82%72.67% (+8.8%)

13% less repeat investments, than reductions

Existing positions increased: 35 | Existing positions reduced: 40

30% less call options, than puts

Call options by funds: $1.36M | Put options by funds: $1.94M

Holders
122
Holders Change
+12
Holders Change %
+10.91%
% of All Funds
1.61%
Holding in Top 10
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
33
Increased
35
Reduced
40
Closed
20
Calls
$1.36M
Puts
$1.94M
Net Calls
-$579K
Net Calls Change
+$1.67M
Name Holding Trade Value Shares
Change
Change in
Stake
PA
1
Perceptive Advisors
New York
$25.6M +$21.9M +4,648,699 +219%
TCM
2
TCG Crossover Management
California
$17.6M
Vanguard Group
3
Vanguard Group
Pennsylvania
$10.2M -$1.87M -397,156 -13%
Bank of America
4
Bank of America
North Carolina
$9.17M +$7.12M +1,513,748 +166%
BlackRock
5
BlackRock
New York
$8.61M -$1.27M -269,272 -11%
AC
6
Almitas Capital
California
$7.68M +$206K +43,807 +2%
Citadel Advisors
7
Citadel Advisors
Florida
$7.45M +$335K +71,144 +4%
6CM
8
683 Capital Management
New York
$7.3M -$329K -70,000 -4%
Goldman Sachs
9
Goldman Sachs
New York
$7.03M +$1.16M +246,033 +15%
BCM
10
Boxer Capital Management
California
$6.62M +$8.23M +1,750,000 New
Aberdeen Group
11
Aberdeen Group
United Kingdom
$6.51M -$1.17M -249,437 -13%
NCM
12
Nantahala Capital Management
Connecticut
$5.49M +$224K +47,589 +3%
Connor, Clark & Lunn Investment Management (CC&L)
13
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$4.78M +$1.8M +382,608 +43%
SVCM
14
Saturn V Capital Management
Texas
$3.36M +$4.18M +889,073 New
Susquehanna International Group
15
Susquehanna International Group
Pennsylvania
$3.28M +$2.18M +462,225 +114%
Alyeska Investment Group
16
Alyeska Investment Group
Illinois
$3.11M -$5.65M -1,200,000 -59%
Qube Research & Technologies (QRT)
17
Qube Research & Technologies (QRT)
United Kingdom
$2.95M +$2.81M +596,672 +324%
Jane Street
18
Jane Street
New York
$2.89M +$1.98M +421,302 +122%
Fidelity Investments
19
Fidelity Investments
Massachusetts
$2.76M +$2.4M +510,355 +231%
Two Sigma Investments
20
Two Sigma Investments
New York
$2.46M +$1.34M +284,280 +77%
UBS Group
21
UBS Group
Switzerland
$2.43M +$1.95M +414,448 +181%
Acadian Asset Management
22
Acadian Asset Management
Massachusetts
$2.31M -$5.45M -1,158,271 -65%
Citigroup
23
Citigroup
New York
$2.3M +$161K +34,319 +6%
Millennium Management
24
Millennium Management
New York
$2.25M +$647K +137,420 +30%
Deutsche Bank
25
Deutsche Bank
Germany
$2.16M

AMLX Hedge Fund Activity: Q4 2024 in Review

122 of the 7,592 institutional investors tracked by Wall St. Rank reported a position in Amylyx Pharmaceuticals (AMLX) for Q4 2024, worth a combined $188M — up 34% from $141M a quarter earlier.

Buyers outnumbered sellers: 33 funds opened new AMLX positions and 20 closed out — a net gain of 13 holders — while 35 added to existing stakes and 40 trimmed.

The largest buyer was Perceptive Advisors, adding an estimated $21.9M. The largest seller was Alyeska Investment Group, cutting an estimated $5.65M.

  • 122 institutional investors held Amylyx Pharmaceuticals (AMLX) as of Q4 2024, up from 110 in Q3 2024.
  • Funds reported $188M of Amylyx Pharmaceuticals stock for Q4 2024, up 34% quarter-over-quarter.
  • 33 funds opened new Amylyx Pharmaceuticals positions in Q4 2024 and 20 closed out, a net change of +13 holders.
  • The largest Amylyx Pharmaceuticals buyer in Q4 2024 was Perceptive Advisors, an estimated $21.9M added.
  • The largest Amylyx Pharmaceuticals seller in Q4 2024 was Alyeska Investment Group, an estimated $5.65M sold.

Based on aggregated 13F filings for Q4 2024.