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Amylyx Pharmaceuticals
AMLX

Overview Fund Activity

134 hedge funds and large institutions have $262M invested in Amylyx Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 32 funds opening new positions, 50 increasing their positions, 31 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
134
Holders Change
+14
Holders Change %
+11.67%
% of All Funds
1.82%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.01%
New
32
Increased
50
Reduced
31
Closed
16
Calls
$524K
Puts
$606K
Net Calls
-$82K
Net Calls Change
+$497K

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
$20.2M
2
Millennium Management
Millennium Management
New York
$10.9M
3
GPP
Great Point Partners
Connecticut
$6.41M
4
WP
Woodline Partners
California
$5.7M
5
SVCM
Saturn V Capital Management
Texas
$8.59M

Top Sellers

1
Bank of America
Bank of America
North Carolina
$2.81M
2
Jane Street
Jane Street
New York
$1.17M
3
CSS
Cubist Systematic Strategies
Connecticut
$294K
4
Acadian Asset Management
Acadian Asset Management
Massachusetts
$855K
5
Walleye Capital
Walleye Capital
New York
$888K
Name Holding Trade Value Shares
Change 		Shares
Change %
PA
1
Perceptive Advisors
New York
$27.9M +$3.89M +1,100,000 +16%
TCM
2
TCG Crossover Management
California
$21M +$4.6M +1,300,000 +28%
Adage Capital Partners
3
Adage Capital Partners
Massachusetts
$20.2M +$20.2M +5,697,605 New
Vanguard Group
4
Vanguard Group
Pennsylvania
$14.6M +$5.04M +1,424,023 +53%
Millennium Management
5
Millennium Management
New York
$10.9M +$8.81M +2,487,617 +419%
NCM
6
Nantahala Capital Management
Connecticut
$10.4M +$5.25M +1,482,252 +102%
Citadel Advisors
7
Citadel Advisors
Florida
$9.76M +$2.79M +787,072 +40%
Aberdeen Group
8
Aberdeen Group
United Kingdom
$8.6M +$2.5M +707,553 +41%
SVCM
9
Saturn V Capital Management
Texas
$8.59M +$5.44M +1,537,363 +173%
6CM
10
683 Capital Management
New York
$8.54M +$1.7M +481,400 +25%
BlackRock
11
BlackRock
New York
$8.45M +$384K +108,475 +5%
AC
12
Almitas Capital
California
$7.51M +$319K +90,227 +4%
Goldman Sachs
13
Goldman Sachs
New York
$7.09M +$506K +143,065 +8%
GPP
14
Great Point Partners
Connecticut
$6.41M +$6.41M +1,811,996 New
BCM
15
Boxer Capital Management
California
$6.2M – – –
WP
16
Woodline Partners
California
$5.7M +$5.7M +1,609,447 New
ACM
17
ADAR1 Capital Management
Texas
$5.21M +$5.21M +1,471,587 New
Susquehanna International Group
18
Susquehanna International Group
Pennsylvania
$5.21M +$2.13M +602,543 +69%
UBS Group
19
UBS Group
Switzerland
$4.92M +$2.64M +744,903 +116%
Connor, Clark & Lunn Investment Management (CC&L)
20
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$4.25M -$225K -63,662 -5%
Fidelity Investments
21
Fidelity Investments
Massachusetts
$4.1M +$1.51M +426,632 +58%
Qube Research & Technologies (QRT)
22
Qube Research & Technologies (QRT)
United Kingdom
$3.34M +$575K +162,325 +21%
Point72 Asset Management
23
Point72 Asset Management
Connecticut
$3.25M +$3.25M +916,966 New
PHS
24
PFM Health Sciences
California
$2.95M +$2.95M +834,135 New
Geode Capital Management
25
Geode Capital Management
Massachusetts
$2.85M +$844K +238,258 +42%
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