Jane Street
AMLX icon

Jane Street’s Amylyx Pharmaceuticals AMLX Stock Holding History

Jane Street’s Portfolio AMLX Stock Details AMLX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$5.38M Buy
+299,565
New +$4.63M ﹤0.01% 3609
2026
Q1 		– Sell
-263,235
Closed -$3.7M – 11474
2025
Q4 		$3.18M Buy
+263,235
New +$3.58M ﹤0.01% 3956
2025
Q3 		– Sell
-186,986
Closed -$1.76M – 10704
2025
Q2 		$1.2M Sell
186,986
-144,199
-44% -$701K ﹤0.01% 5273
2025
Q1 		$1.17M Sell
331,185
-434,290
-57% -$1.55M ﹤0.01% 5272
2024
Q4 		$2.89M Buy
765,475
+421,302
+122% +$1.98M ﹤0.01% 3511
2024
Q3 		$1.12M Sell
344,173
-146,934
-30% -$330K ﹤0.01% 5660
2024
Q2 		$933K Sell
491,107
-536,513
-52% -$1.04M ﹤0.01% 5903
2024
Q1 		$2.92M Sell
1,027,620
-129,545
-11% -$1.69M ﹤0.01% 3455
2023
Q4 		$17M Buy
1,157,165
+555,877
+92% +$8.52M ﹤0.01% 1414
2023
Q3 		$11M Buy
601,288
+127,895
+27% +$2.7M ﹤0.01% 1679
2023
Q2 		$10.2M Buy
473,393
+208,535
+79% +$5.63M ﹤0.01% 1879
2023
Q1 		$7.77M Buy
264,858
+128,301
+94% +$4.46M ﹤0.01% 1897
2022
Q4 		$5.05M Buy
+136,557
New +$4.85M ﹤0.01% 2460
2022
Q3 		– Sell
-179,602
Closed -$4.48M – 9629
2022
Q2 		$3.46M Buy
179,602
+150,356
+514% +$1.79M ﹤0.01% 3214
2022
Q1 		$376K Buy
+29,246
New +$661K ﹤0.01% 7998

Other funds holding AMLX

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $4.16B AUM 983.43% 1-Year Est. Return
CC
Commodore Capital New York $1.68B AUM 375.52% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM
SVCM
Saturn V Capital Management Austin, Texas $697M AUM 628.57% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Morgan Stanley
Morgan Stanley New York $1.89T AUM 35.08% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

Jane Street's AMLX Position: Q2 2026 in Review

Jane Street opened a new position in Amylyx Pharmaceuticals (AMLX) in Q2 2026: 299,565 shares worth $5.38M. The stake represents ﹤0.01% of the portfolio and ranks #3609 among its holdings. This is a return to the name: Jane Street previously reported a position in AMLX as recently as Q4 2025.

Jane Street first reported a position in AMLX in Q1 2022 and has held it in 15 quarters since. The position peaked at $17M in Q4 2023. 206 funds tracked by Wall St. Rank hold AMLX as of Q2 2026.

  • Jane Street held 299,565 shares of Amylyx Pharmaceuticals worth $5.38M as of Q2 2026.
  • Amylyx Pharmaceuticals was a new Jane Street position in Q2 2026.
  • Amylyx Pharmaceuticals made up ﹤0.01% of Jane Street's portfolio in Q2 2026, its #3609 holding.
  • Jane Street first reported a position in Amylyx Pharmaceuticals in Q1 2022 and has held it in 15 quarters since.
  • Jane Street's Amylyx Pharmaceuticals position peaked at $17M in Q4 2023.
  • 206 funds tracked by Wall St. Rank held Amylyx Pharmaceuticals as of Q2 2026.

Based on Jane Street's 13F filing for Q2 2026, filed 14 Aug 2026.