Siren LLC Portfolio holdings

AUM $1.93B

1-Year Est. Return 118.08%

2025 Q2 2025 Q1 2024 Q4 2024 Q3

This Quarter Est. Return

1 Year Est. Return

+118.08%

3 Year Est. Return

5 Year Est. Return

10 Year Est. Return

AUM

$1.77B

AUM Growth

-$491M (-22%)

Cap. Flow

Cap. Flow % of AUM

Top 10 Holdings % Top 10 Hldgs %

Holding

140

New

Increased

Reduced

Closed

Top Buys

1		+$64.3M
2		+$53.2M
3		+$26.8M
4	Edgewise Therapeutics EWTX	+$21.2M
5	Rhythm Pharmaceuticals RYTM	+$14.7M

Top Sells

1		+$70.8M
2		+$49.8M
3		+$42.2M
4	Madrigal Pharmaceuticals MDGL	+$38.9M
5	Cytokinetics CYTK	+$18.9M

Sector Composition

1	Healthcare	89.75%
2	Technology	5.2%
3	Communication Services	2.41%
4	Consumer Discretionary	1.21%
5	Real Estate	0.81%

Communication Services

Advertising Agencies

Broadcasting

Electronic Gaming & Multimedia

Entertainment

Internet Content & Information

Publishing

Telecom Services

Consumer Discretionary

Apparel Manufacturing

Apparel Retail

Auto Manufacturers

Auto Parts

Auto & Truck Dealerships

Department Stores

Footwear & Accessories

Furnishings, Fixtures & Appliances

Gambling

Home Improvement Retail

Internet Retail

Leisure

Lodging

Luxury Goods

Packaging & Containers

Personal Services

Recreational Vehicles

Residential Construction

Resorts & Casinos

Restaurants

Specialty Retail

Textile Manufacturing

Travel Services

Consumer Staples

Beverages - Brewers

Beverages - Non-Alcoholic

Beverages - Wineries & Distilleries

Confectioners

Discount Stores

Education & Training Services

Farm Products

Food Distribution

Grocery Stores

Household & Personal Products

Packaged Foods

Tobacco

Energy

Oil & Gas Drilling

Oil & Gas Equipment & Services

Oil & Gas Exploration & Production

Oil & Gas Integrated

Oil & Gas Midstream

Oil & Gas Refining & Marketing

Thermal Coal

Uranium

Financials

Asset Management

Banks - Diversified

Banks - Regional

Capital Markets

Credit Services

Diversified Insurance

Financial Conglomerates

Financial Data & Stock Exchanges

Insurance Brokers

Life Insurance

Mortgage Finance

Property & Casualty Insurance

Reinsurance

Shell Companies

Specialty - Insurance

Healthcare

Biotechnology

Diagnostics & Research

Drug Manufacturers - General

Drug Manufacturers - Specialty & Generic

Healthcare Plans

Health Information Services

Medical Care Facilities

Medical Devices

Medical Distribution

Medical Instruments & Supplies

Pharmaceutical Retailers

Industrials

Aerospace & Defense

Airlines

Airports & Air Services

Building Products & Equipment

Business Equipment & Supplies

Conglomerates

Consulting Services

Electrical Equipment & Parts

Engineering & Construction

Farm & Heavy Construction Machinery

Industrial Distribution

Infrastructure Operations

Integrated Freight & Logistics

Marine Shipping

Metal Fabrication

Pollution & Treatment Controls

Railroads

Rental & Leasing Services

Security & Protection Services

Specialty Business Services

Specialty Industrial Machinery

Staffing & Employment Services

Tools & Accessories

Trucking

Waste Management

Materials

Agricultural Inputs

Aluminum

Building Materials

Chemicals

Coking Coal

Copper

Gold

Lumber & Wood Production

Other Industrial Metals & Mining

Other Precious Metals & Mining

Paper & Paper Products

Silver

Specialty Chemicals

Steel

Real Estate

Diversified REIT

Healthcare Facilities REIT

Hotel & Motel REIT

Industrial REIT

Mortgage REIT

Office REIT

Real Estate Development

Real Estate Diversified

Real Estate Services

Residential REIT

Retail REIT

Specialty REIT

Technology

Communication Equipment

Computer Hardware

Consumer Electronics

Electronic Components

Electronics & Computer Distribution

Information Technology Services

Scientific & Technical Instruments

Semiconductor Equipment & Materials

Semiconductors

Software - Application

Software - Infrastructure

Solar

Utilities

Diversified Utilities

Electric Utilities

Gas Utilities

Independent Power Producers

Renewable Electricity

Water Utilities

#	Name	Market Value	Portfolio Weight	Shares or Principal
26	26 Lexicon Pharmaceuticals LXRX $498M	$17.9M	1.01%	38,918,903
27	27 Prothena Corp PRTA $567M	$15.9M	0.9%	1,283,555 +183,715
28	BCYC 28 Bicycle Therapeutics BCYC $570M	$15.4M	0.87%	1,812,752 -26,646
29	29 Stoke Therapeutics STOK $1.73B	$14.9M	0.84%	2,247,347 +247,347
30	30 Rhythm Pharmaceuticals RYTM $7.54B	$14.7M	0.83%	+277,533
31	31 Summit Therapeutics SMMT $14.3B	$13.4M	0.76%	+695,000
32	SEPN 32 Septerna Inc SEPN $995M	$12.8M	0.72%	2,202,514
33	33 Arcus Biosciences RCUS $2.12B	$12.7M	0.71%	1,612,077
34	34 IHS Holding IHS $2.33B	$12.3M	0.69%	2,357,520
35	35 Erasca ERAS $692M	$12M	0.68%	8,757,249 -99,930
36	36 Denali Therapeutics DNLI $2.47B	$11.2M	0.63%	821,513 -12,515
37	37 Vaxcyte PCVX $5.79B	$11.2M	0.63%	295,543 -4,448
38	38 Amazon AMZN $2.44T	$10.7M	0.61%	56,500 +20,000
39	39 Microsoft MSFT $4.03T	$10.7M	0.6%	28,500 +5,500
40	40 Remitly RELY $3.43B	$10.2M	0.58%	490,449
41	41 Taysha Gene Therapies TSHA $1.36B	$9.06M	0.51%	6,514,737 -87,738
42	42 Cullinan Oncology CGEM $502M	$9.03M	0.51%	1,193,410 -17,947
43	43 CrowdStrike CRWD $137B	$8.81M	0.5%	25,000 +1,000
44	SLN 44 Silence Therapeutics SLN $345M	$7.87M	0.44%	2,789,833 -41,937
45	45 Alphabet (Google) Class A GOOGL $3.23T	$7.84M	0.44%	50,703 +43,703
46	46 Cartesian Therapeutics RNAC $216M	$7.42M	0.42%	563,272 -8,964
47	47 Adobe ADBE $151B	$7.4M	0.42%	19,298 +10,500
48	48 Korro Bio KRRO $376M	$7.29M	0.41%	418,833
49	49 ServiceNow NOW $195B	$7.27M	0.41%	9,126 +3,521
50	50 Seer Inc SEER $129M	$6.76M	0.38%	4,000,000