SL
Siren LLC Portfolio holdings
AUM
$1.93B
This Quarter Return
-13.7%
1 Year Return
+118.08%
3 Year Return
–
5 Year Return
–
10 Year Return
–
AUM
$1.77B
AUM Growth
+$1.77B
(-22%)
Cap. Flow
-$54.5M
Cap. Flow
% of AUM
-3.08%
Top 10 Holdings %
Top 10 Hldgs %
50.37%
Holding
140
New
23
Increased
28
Reduced
41
Closed
24
Top Buys
| 1 |
BPMC
Blueprint Medicines
BPMC
|
$64.3M |
| 2 |
Disc Medicine
IRON
|
$53.2M |
| 3 |
Soleno Therapeutics
SLNO
|
$26.8M |
| 4 |
Edgewise Therapeutics
EWTX
|
$21.2M |
| 5 |
Rhythm Pharmaceuticals
RYTM
|
$14.7M |
Top Sells
| 1 |
argenx
ARGX
|
$70.8M |
| 2 |
SWTX
SpringWorks Therapeutics
SWTX
|
$49.8M |
| 3 |
ONC
BeOne Medicines Ltd. American Depositary Shares
ONC
|
$42.2M |
| 4 |
Madrigal Pharmaceuticals
MDGL
|
$38.9M |
| 5 |
Cytokinetics
CYTK
|
$18.9M |
Sector Composition
| 1 | Healthcare | 89.75% |
| 2 | Technology | 5.2% |
| 3 | Communication Services | 2.41% |
| 4 | Consumer Discretionary | 1.21% |
| 5 | Real Estate | 0.81% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Shares Change % | Capital Flow | |
|---|---|---|---|---|---|---|
26
Lexicon Pharmaceuticals
LXRX
$392M
| $17.9M | 1.01% |
38,918,903
| – | – |
|
27
Prothena Corp
PRTA
$452M
| $15.9M | 0.9% |
1,283,555
+183,715
| +17% | +$2.27M |
|
|
BCYC
28
Bicycle Therapeutics
BCYC
$492M
| $15.4M | 0.87% |
1,812,752
-26,646
| -1% | -$226K |
|
29
Stoke Therapeutics
STOK
$1.08B
| $14.9M | 0.84% |
2,247,347
+247,347
| +12% | +$1.64M |
|
|
30
Rhythm Pharmaceuticals
RYTM
$6.75B
| $14.7M | 0.83% |
+277,533
| New | +$14.7M |
|
31
Summit Therapeutics
SMMT
$17.5B
| $13.4M | 0.76% |
+695,000
| New | +$13.4M |
|
|
SEPN
32
Septerna, Inc. Common Stock
SEPN
$628M
| $12.8M | 0.72% |
2,202,514
| – | – |
|
33
Arcus Biosciences
RCUS
$1.24B
| $12.7M | 0.71% |
1,612,077
| – | – |
|
34
IHS Holding
IHS
$2.43B
| $12.3M | 0.69% |
2,357,520
| – | – |
|
35
Erasca
ERAS
$406M
| $12M | 0.68% |
8,757,249
-99,930
| -1% | -$137K |
|
36
Denali Therapeutics
DNLI
$2.24B
| $11.2M | 0.63% |
821,513
-12,515
| -2% | -$170K |
|
37
Vaxcyte
PCVX
$4.17B
| $11.2M | 0.63% |
295,543
-4,448
| -1% | -$168K |
|
38
Amazon
AMZN
$2.41T
| $10.7M | 0.61% |
56,500
+20,000
| +55% | +$3.81M |
|
39
Microsoft
MSFT
$3.76T
| $10.7M | 0.6% |
28,500
+5,500
| +24% | +$2.06M |
|
40
Remitly
RELY
$4.01B
| $10.2M | 0.58% |
490,449
| – | – |
|
41
Taysha Gene Therapies
TSHA
$791M
| $9.06M | 0.51% |
6,514,737
-87,738
| -1% | -$122K |
|
42
Cullinan Oncology
CGEM
$456M
| $9.03M | 0.51% |
1,193,410
-17,947
| -1% | -$136K |
|
43
CrowdStrike
CRWD
$104B
| $8.81M | 0.5% |
25,000
+1,000
| +4% | +$353K |
|
|
SLN
44
Silence Therapeutics
SLN
$237M
| $7.87M | 0.44% |
2,789,833
-41,937
| -1% | -$118K |
|
45
Alphabet (Google) Class A
GOOGL
$2.79T
| $7.84M | 0.44% |
50,703
+43,703
| +624% | +$6.76M |
|
46
Cartesian Therapeutics
RNAC
$267M
| $7.42M | 0.42% |
563,272
-8,964
| -2% | -$118K |
|
47
Adobe
ADBE
$148B
| $7.4M | 0.42% |
19,298
+10,500
| +119% | +$4.03M |
|
48
Korro Bio
KRRO
$245M
| $7.29M | 0.41% |
418,833
| – | – |
|
49
ServiceNow
NOW
$191B
| $7.27M | 0.41% |
9,126
+3,521
| +63% | +$2.8M |
|
50
Seer Inc
SEER
$114M
| $6.76M | 0.38% |
4,000,000
| – | – |
|