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SL

Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
-13.7%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$1.77B
AUM Growth
-$491M
Cap. Flow
+$34.8M
Cap. Flow %
1.96%
Top 10 Hldgs %
50.37%
Holding
141
New
23
Increased
28
Reduced
41
Closed
25

Top Buys

Rank Stock Value
1
BPMC
Blueprint Medicines
BPMC
+$70.8M
2
IRON icon
Disc Medicine
IRON
+$59.6M
3
EWTX icon
Edgewise Therapeutics
EWTX
+$25.2M
4
DYN icon
Dyne Therapeutics
DYN
+$19.6M
5
SLNO
Soleno Therapeutics
SLNO
+$18.3M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$70.8M
2
SWTX
SpringWorks Therapeutics
SWTX
+$49.8M
3
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$38.9M
4
ONC
BeOne Medicines Ltd
ONC
+$36.2M
5
CYTK icon
Cytokinetics
CYTK
+$18.9M

Sector Composition

Rank Sector Weight
1 Healthcare 89.75%
2 Technology 5.2%
3 Communication Services 2.41%
4 Consumer Discretionary 1.21%
5 Real Estate 0.81%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
LXRX icon
26
Lexicon Pharmaceuticals
LXRX
$1.1B
$17.9M 1.01%
38,918,903
– –
PRTA icon
27
Prothena Corp
PRTA
$450M
$15.9M 0.9%
1,283,555
+183,715
+17% +$2.6M
BCYC
28
Bicycle Therapeutics
BCYC
$292M
$15.4M 0.87%
1,812,752
-26,646
-1% -$314K
STOK icon
29
Stoke Therapeutics
STOK
$2.11B
$14.9M 0.84%
2,247,347
+247,347
+12% +$2.31M
RYTM icon
30
Rhythm Pharmaceuticals
RYTM
$7.96B
$14.7M 0.83%
+277,533
New +$15.4M
SMMT icon
31
Summit Therapeutics
SMMT
$11.1B
$13.4M 0.76%
+695,000
New +$13.9M
SEPN
32
Septerna Inc
SEPN
$1.75B
$12.8M 0.72%
2,202,514
– –
RCUS icon
33
Arcus Biosciences
RCUS
$3.64B
$12.7M 0.71%
1,612,077
– –
IHS icon
34
IHS Holding
IHS
$2.81B
$12.3M 0.69%
2,357,520
– –
ERAS icon
35
Erasca
ERAS
$6.39B
$12M 0.68%
8,757,249
-99,930
-1% -$172K
DNLI icon
36
Denali Therapeutics
DNLI
$3.97B
$11.2M 0.63%
821,513
-12,515
-2% -$240K
PCVX icon
37
Vaxcyte
PCVX
$8.64B
$11.2M 0.63%
295,543
-4,448
-1% -$356K
AMZN icon
38
Amazon
AMZN
$2.96T
$10.7M 0.61%
56,500
+20,000
+55% +$4.34M
MSFT icon
39
Microsoft
MSFT
$3.71T
$10.7M 0.6%
28,500
+5,500
+24% +$2.24M
RELY icon
40
Remitly
RELY
$5.14B
$10.2M 0.58%
490,449
– –
TSHA icon
41
Taysha Gene Therapies
TSHA
$1.89B
$9.06M 0.51%
6,514,737
-87,738
-1% -$147K
CGEM icon
42
Cullinan Oncology
CGEM
$1.14B
$9.03M 0.51%
1,193,410
-17,947
-1% -$172K
CRWD icon
43
CrowdStrike
CRWD
$218B
$8.81M 0.5%
100,000
+4,000
+4% +$381K
SLN
44
Silence Therapeutics
SLN
$564M
$7.87M 0.44%
2,789,833
-41,937
-1% -$205K
GOOGL icon
45
Alphabet (Google) Class A
GOOGL
$4.33T
$7.84M 0.44%
50,703
+43,703
+624% +$7.93M
RNAC icon
46
Cartesian Therapeutics
RNAC
$268M
$7.42M 0.42%
563,272
-8,964
-2% -$160K
ADBE icon
47
Adobe
ADBE
$105B
$7.4M 0.42%
19,298
+10,500
+119% +$4.5M
KRRO icon
48
Korro Bio
KRRO
$195M
$7.29M 0.41%
418,833
– –
NOW icon
49
ServiceNow
NOW
$129B
$7.27M 0.41%
45,630
+17,605
+63% +$3.39M
SEER icon
50
Seer Inc
SEER
$120M
$6.76M 0.38%
4,000,000
– –
1
2
3 4 5

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GCM
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VI
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BPS
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VPC
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WWA
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OCM
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Siren LLC's Q1 2025 Portfolio in Review

As of Q1 2025, Siren LLC held 141 positions worth $1.77B, down 22% from $2.26B the previous quarter. Its ten largest holdings account for 50% of the portfolio.

Siren LLC's Q1 2025 filing shows 23 new, 28 increased, 41 reduced and 25 closed positions. Its largest new stake was Blueprint Medicines: 726,167 shares worth $64.3M. The largest sale was argenx, an estimated $70.8M.

By sector, the portfolio is most concentrated in Healthcare at 90% of assets, down from 93% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q1 2025 buy was Blueprint Medicines: 726,167 shares worth $64.3M.
  • Siren LLC added most to Edgewise Therapeutics in Q1 2025, an estimated $25.2M increase.
  • Siren LLC's biggest Q1 2025 reduction was BeOne Medicines Ltd, cutting an estimated $36.2M.
  • Siren LLC fully exited argenx in Q1 2025, selling an estimated $70.8M.
  • Siren LLC's ten largest holdings make up 50% of its $1.77B portfolio in Q1 2025.
  • Siren LLC opened 23 new positions and closed 25 in Q1 2025.
  • Siren LLC's portfolio value fell 22% quarter-over-quarter to $1.77B.

Based on Siren LLC's 13F filing for Q1 2025, filed 14 May 2025.