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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+1.77%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.85B
AUM Growth
+$217M
Cap. Flow
+$578M
Cap. Flow %
8.44%
Top 10 Hldgs %
38.32%
Holding
136
New
16
Increased
27
Reduced
15
Closed
11

Top Buys

Rank Stock Value
1
RARE icon
Ultragenyx Pharmaceutical
RARE
+$112M
2
APLS
Apellis Pharmaceuticals
APLS
+$78.4M
3
PEN icon
Penumbra
PEN
+$62.3M
4
ALNY icon
Alnylam Pharmaceuticals
ALNY
+$54.4M
5
ARGX icon
argenx
ARGX
+$53.9M

Top Sells

Rank Stock Value
1
DRNA
Dicerna Pharmaceuticals, Inc.
DRNA
+$153M
2
INMD icon
InMode
INMD
+$19.9M
3
IDYA icon
IDEAYA Biosciences
IDYA
+$17.3M
4
AGEN
Agenus
AGEN
+$12.9M
5
GH icon
Guardant Health
GH
+$11.6M

Sector Composition

Rank Sector Weight
1 Healthcare 93.33%
2 Financials 0.42%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
BNR
126
Burning Rock Biotech
BNR
$92.9M
– –
-3,000
Closed -$536K
CVRX icon
127
CVRx
CVRX
$63.4M
– –
-150,000
Closed -$2.48M
INMD icon
128
InMode
INMD
$880M
– –
-249,998
Closed -$19.9M
MLTX icon
129
MoonLake Immunotherapeutics
MLTX
$1.55B
– –
-750,000
Closed -$7.39M
PROF
130
Profound Medical
PROF
$269M
– –
-122,098
Closed -$1.79M
SRRK icon
131
Scholar Rock
SRRK
$6.44B
– –
-161,612
Closed -$5.34M
TWST icon
132
Twist Bioscience
TWST
$7.25B
– –
-18,473
Closed -$1.98M
AFIB
133
DELISTED
Acutus Medical Inc
AFIB
– –
-491,834
Closed -$4.35M
CELL
134
DELISTED
PhenomeX Inc. Common Stock
CELL
– –
-257,546
Closed -$5.04M
DRNA
135
DELISTED
Dicerna Pharmaceuticals, Inc.
DRNA
– –
-7,582,396
Closed -$153M
MAAC
136
DELISTED
Montes Archimedes Acquisition Corp. Class A Common Stock
MAAC
– –
-400,000
Closed -$3.16M
2 3 4 5
6

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RTW Investments's Q4 2021 Portfolio in Review

As of Q4 2021, RTW Investments held 136 positions worth $6.85B, up 3.3% from $6.63B the previous quarter. Its ten largest holdings account for 38% of the portfolio.

RTW Investments deployed $578M of net new capital in Q4 2021, opening 16 new positions and adding to 27 existing holdings. Its largest new stake was Ultragenyx Pharmaceutical: 1,373,284 shares worth $115M.

By sector, the portfolio is most concentrated in Healthcare at 93% of assets, up from 91% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was IDEAYA Biosciences, an estimated $17.3M trimmed.

  • RTW Investments's largest Q4 2021 buy was Ultragenyx Pharmaceutical: 1,373,284 shares worth $115M.
  • RTW Investments added most to Penumbra in Q4 2021, an estimated $62.3M increase.
  • RTW Investments's biggest Q4 2021 reduction was IDEAYA Biosciences, cutting an estimated $17.3M.
  • RTW Investments fully exited Dicerna Pharmaceuticals, Inc. in Q4 2021, selling an estimated $153M.
  • RTW Investments's ten largest holdings make up 38% of its $6.85B portfolio in Q4 2021.
  • RTW Investments opened 16 new positions and closed 11 in Q4 2021.
  • RTW Investments's portfolio value rose 3.3% quarter-over-quarter to $6.85B.

Based on RTW Investments's 13F filing for Q4 2021, filed 14 Feb 2022.