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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+9.11%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$7.02B
AUM Growth
+$483M
Cap. Flow
+$199M
Cap. Flow %
2.83%
Top 10 Hldgs %
49.95%
Holding
78
New
10
Increased
26
Reduced
8
Closed
5

Top Buys

Rank Stock Value
1
NBIX icon
Neurocrine Biosciences
NBIX
+$122M
2
ZLAB icon
Zai Lab
ZLAB
+$78.9M
3
DGX icon
Quest Diagnostics
DGX
+$69.7M
4
ABT icon
Abbott
ABT
+$58.5M
5
JBIO
Jade Biosciences
JBIO
+$49.3M

Top Sells

Rank Stock Value
1
AXSM icon
Axsome Therapeutics
AXSM
+$149M
2
AKRO
Akero Therapeutics
AKRO
+$88.2M
3
GMED icon
Globus Medical
GMED
+$82.3M
4
ALKS icon
Alkermes
ALKS
+$65.5M
5
ARVN icon
Arvinas
ARVN
+$23.4M

Sector Composition

Rank Sector Weight
1 Healthcare 99.89%
2 Financials 0.11%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
GKOS icon
76
Glaukos
GKOS
$10.6B
– –
-190,000
Closed -$18.7M
GMED icon
77
Globus Medical
GMED
$11.2B
– –
-1,125,000
Closed -$82.3M
BIOA
78
BioAge Labs
BIOA
$538M
– –
-786,353
Closed -$2.96M
1 2 3
4

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RTW Investments's Q2 2025 Portfolio in Review

As of Q2 2025, RTW Investments held 78 positions worth $7.02B, up 7.4% from $6.54B the previous quarter. Its ten largest holdings account for 50% of the portfolio.

RTW Investments's Q2 2025 filing shows 10 new, 26 increased, 8 reduced and 5 closed positions. Its largest new stake was Neurocrine Biosciences: 1,062,072 shares worth $133M. The largest sale was Axsome Therapeutics, an estimated $149M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q2 2025 buy was Neurocrine Biosciences: 1,062,072 shares worth $133M.
  • RTW Investments added most to Zai Lab in Q2 2025, an estimated $78.9M increase.
  • RTW Investments's biggest Q2 2025 reduction was Axsome Therapeutics, cutting an estimated $149M.
  • RTW Investments fully exited Globus Medical in Q2 2025, selling an estimated $82.3M.
  • RTW Investments's ten largest holdings make up 50% of its $7.02B portfolio in Q2 2025.
  • RTW Investments opened 10 new positions and closed 5 in Q2 2025.
  • RTW Investments's portfolio value rose 7.4% quarter-over-quarter to $7.02B.

Based on RTW Investments's 13F filing for Q2 2025, filed 14 Aug 2025.