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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+4.01%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.54B
AUM Growth
-$74.4M
Cap. Flow
+$91.3M
Cap. Flow %
1.4%
Top 10 Hldgs %
52.67%
Holding
82
New
10
Increased
18
Reduced
7
Closed
14

Top Buys

Rank Stock Value
1
ISRG icon
Intuitive Surgical
ISRG
+$112M
2
BBNX
Beta Bionics
BBNX
+$61.5M
3
VRNA
Verona Pharma
VRNA
+$61.5M
4
QURE icon
uniQure
QURE
+$47.1M
5
GEHC icon
GE HealthCare
GEHC
+$44.7M

Top Sells

Rank Stock Value
1
BRKR icon
Bruker
BRKR
+$145M
2
AXSM icon
Axsome Therapeutics
AXSM
+$129M
3
DYN icon
Dyne Therapeutics
DYN
+$50.5M
4
ETNB
89bio
ETNB
+$48.2M
5
ALKS icon
Alkermes
ALKS
+$22M

Sector Composition

Rank Sector Weight
1 Healthcare 99.88%
2 Financials 0.12%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PEPG icon
76
PepGen
PEPG
$197M
– –
-3,193,097
Closed -$12.1M
RGNX icon
77
Regenxbio
RGNX
$708M
– –
-350,000
Closed -$2.71M
ROIV icon
78
Roivant Sciences
ROIV
$26.2B
– –
-1,454,273
Closed -$17.2M
SAGE
79
DELISTED
Sage Therapeutics
SAGE
– –
-3,002,370
Closed -$16.3M
SLRN
80
DELISTED
ACELYRIN
SLRN
– –
-978,310
Closed -$3.07M
TRML
81
DELISTED
Tourmaline Bio
TRML
– –
-736,681
Closed -$14.9M
ARTV
82
Artiva Biotherapeutics
ARTV
$551M
– –
-148,844
Closed -$1.5M
1 2 3
4

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RTW Investments's Q1 2025 Portfolio in Review

As of Q1 2025, RTW Investments held 82 positions worth $6.54B, down 1.1% from $6.61B the previous quarter. Its ten largest holdings account for 53% of the portfolio.

RTW Investments's Q1 2025 filing shows 10 new, 18 increased, 7 reduced and 14 closed positions. Its largest new stake was Intuitive Surgical: 202,456 shares worth $100M. The largest sale was Bruker, an estimated $145M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q1 2025 buy was Intuitive Surgical: 202,456 shares worth $100M.
  • RTW Investments added most to Verona Pharma in Q1 2025, an estimated $61.5M increase.
  • RTW Investments's biggest Q1 2025 reduction was Axsome Therapeutics, cutting an estimated $129M.
  • RTW Investments fully exited Bruker in Q1 2025, selling an estimated $145M.
  • RTW Investments's ten largest holdings make up 53% of its $6.54B portfolio in Q1 2025.
  • RTW Investments opened 10 new positions and closed 14 in Q1 2025.
  • RTW Investments's portfolio value fell 1.1% quarter-over-quarter to $6.54B.

Based on RTW Investments's 13F filing for Q1 2025, filed 15 May 2025.