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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+18.13%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$4.9B
AUM Growth
+$561M
Cap. Flow
+$279M
Cap. Flow %
5.7%
Top 10 Hldgs %
55.22%
Holding
87
New
1
Increased
20
Reduced
10
Closed
10

Top Buys

Rank Stock Value
1
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$114M
2
AXSM icon
Axsome Therapeutics
AXSM
+$65.6M
3
RARE icon
Ultragenyx Pharmaceutical
RARE
+$63.2M
4
IMCR icon
Immunocore
IMCR
+$62.4M
5
RCKT icon
Rocket Pharmaceuticals
RCKT
+$34.7M

Top Sells

Rank Stock Value
1
ISEE
IVERIC bio, Inc. Common Stock
ISEE
+$59.8M
2
TSVT
2seventy bio
TSVT
+$17.9M
3
TNDM icon
Tandem Diabetes Care
TNDM
+$15.4M
4
GH icon
Guardant Health
GH
+$13.5M
5
RCOR
Renovacor, Inc.
RCOR
+$7.56M

Sector Composition

Rank Sector Weight
1 Healthcare 99.63%
2 Financials 0.27%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MIRO
76
DELISTED
Miromatrix Medical Inc. Common Stock
MIRO
$837K 0.02%
280,000
– –
MSACW
77
DELISTED
Medicus Sciences Acquisition Corp. Warrant
MSACW
$3K ﹤0.01%
33,331
– –
EPIX
78
DELISTED
ESSA Pharma
EPIX
– –
-1,311,294
Closed -$2.39M
TNDM icon
79
Tandem Diabetes Care
TNDM
$1.56B
– –
-322,000
Closed -$15.4M
TSVT
80
DELISTED
2seventy bio
TSVT
– –
-1,229,508
Closed -$17.9M
ASLN
81
DELISTED
ASLAN Pharmaceuticals Limited American Depositary Shares
ASLN
– –
-75,400
Closed -$1.81M
LABP
82
DELISTED
Landos Biopharma, Inc. Common Stock
LABP
– –
-397,572
Closed -$2.58M
RACB
83
DELISTED
Research Alliance Corp. II Class A Common Stock
RACB
– –
-637,000
Closed -$6.26M
RCOR.WS
84
DELISTED
Renovacor, Inc. Warrants, entitling the holder thereof to purchase one-half (1/2) of a share of common stock at a price of $11. 50 per whole share
RCOR.WS
– –
-350,000
Closed -$28K
RCOR
85
DELISTED
Renovacor, Inc.
RCOR
– –
-3,000,803
Closed -$7.56M
BLSA
86
DELISTED
BCLS Acquisition Corp. Class A Ordinary Shares
BLSA
– –
-612,500
Closed -$6.14M
FVAM
87
DELISTED
5:01 Acquisition Corp
FVAM
– –
-392,000
Closed -$3.92M
1 2 3
4

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RA
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GI
GAMCO Investors Greenwich, Connecticut $10.2B AUM 30.27% 1-Year Est. Return
IIM
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ACA
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VPIM
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HI
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MF
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RTW Investments's Q4 2022 Portfolio in Review

As of Q4 2022, RTW Investments held 87 positions worth $4.9B, up 13% from $4.34B the previous quarter. Its ten largest holdings account for 55% of the portfolio.

RTW Investments deployed $279M of net new capital in Q4 2022, opening 1 new position and adding to 20 existing holdings. Its largest new stake was Terns Pharmaceuticals: 1,000,000 shares worth $10.2M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 99% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was IVERIC bio, Inc. Common Stock, an estimated $59.8M trimmed.

  • RTW Investments's largest Q4 2022 buy was Terns Pharmaceuticals: 1,000,000 shares worth $10.2M.
  • RTW Investments added most to Mirati Therapeutics, Inc. Common Stock in Q4 2022, an estimated $114M increase.
  • RTW Investments's biggest Q4 2022 reduction was IVERIC bio, Inc. Common Stock, cutting an estimated $59.8M.
  • RTW Investments fully exited 2seventy bio in Q4 2022, selling an estimated $17.9M.
  • RTW Investments's ten largest holdings make up 55% of its $4.9B portfolio in Q4 2022.
  • RTW Investments opened 1 new position and closed 10 in Q4 2022.
  • RTW Investments's portfolio value rose 13% quarter-over-quarter to $4.9B.

Based on RTW Investments's 13F filing for Q4 2022, filed 14 Feb 2023.