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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+4.01%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.54B
AUM Growth
-$74.4M
Cap. Flow
+$91.3M
Cap. Flow %
1.4%
Top 10 Hldgs %
52.67%
Holding
82
New
10
Increased
18
Reduced
7
Closed
14

Top Buys

Rank Stock Value
1
ISRG icon
Intuitive Surgical
ISRG
+$112M
2
BBNX
Beta Bionics
BBNX
+$61.5M
3
VRNA
Verona Pharma
VRNA
+$61.5M
4
QURE icon
uniQure
QURE
+$47.1M
5
GEHC icon
GE HealthCare
GEHC
+$44.7M

Top Sells

Rank Stock Value
1
BRKR icon
Bruker
BRKR
+$145M
2
AXSM icon
Axsome Therapeutics
AXSM
+$129M
3
DYN icon
Dyne Therapeutics
DYN
+$50.5M
4
ETNB
89bio
ETNB
+$48.2M
5
ALKS icon
Alkermes
ALKS
+$22M

Sector Composition

Rank Sector Weight
1 Healthcare 99.88%
2 Financials 0.12%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
NGNE icon
51
Neurogene
NGNE
$712M
$15.8M 0.24%
1,348,656
-1,600
-0.1% -$27.8K
RAPT
52
DELISTED
RAPT Therapeutics
RAPT
$14.4M 0.22%
1,470,500
– –
ETNB
53
DELISTED
89bio
ETNB
$14.3M 0.22%
1,967,527
-5,510,534
-74% -$48.2M
CGEM icon
54
Cullinan Oncology
CGEM
$1.14B
$12.9M 0.2%
1,705,960
– –
BEAM icon
55
Beam Therapeutics
BEAM
$2.84B
$8.57M 0.13%
+438,659
New +$11.5M
CRVS icon
56
Corvus Pharmaceuticals
CRVS
$1.17B
$8.52M 0.13%
2,679,479
– –
PCSC
57
DELISTED
Perceptive Capital Solutions
PCSC
$7.65M 0.12%
742,500
– –
WVE icon
58
Wave Life Sciences
WVE
$1.2B
$7.27M 0.11%
900,000
– –
XGN icon
59
Exagen
XGN
$166M
$5.43M 0.08%
1,511,866
– –
KMTS
60
Kestra Medical Technologies
KMTS
$1.55B
$4.98M 0.08%
+200,000
New +$4.6M
ALUR
61
DELISTED
Allurion Technologies
ALUR
$3.37M 0.05%
1,050,063
+932,161
+791% +$4.01M
BIOA
62
BioAge Labs
BIOA
$538M
$2.96M 0.05%
786,353
– –
CBLL
63
CeriBell Inc
CBLL
$714M
$2.88M 0.04%
150,000
– –
TENX icon
64
Tenax Therapeutics
TENX
$503M
$2.48M 0.04%
+378,346
New +$2.43M
MIST icon
65
Milestone Pharmaceuticals
MIST
$152M
$2.01M 0.03%
2,506,102
– –
CNTA
66
DELISTED
Centessa Pharmaceuticals
CNTA
$719K 0.01%
50,000
– –
ADGM
67
Adagio Medical Holdings
ADGM
$15.2M
$169K ﹤0.01%
209,361
– –
RCKTW icon
68
Rocket Pharmaceuticals Warrant
RCKTW
$288K
$16.4K ﹤0.01%
350,000
– –
BRKR icon
69
Bruker
BRKR
$8.14B
– –
-2,481,119
Closed -$145M
DNTH icon
70
Dianthus Therapeutics
DNTH
$6.09B
– –
-666,667
Closed -$14.5M
EPIX
71
DELISTED
ESSA Pharma
EPIX
– –
-1,113,002
Closed -$1.99M
GPCR icon
72
Structure Therapeutics
GPCR
$3.78B
– –
-125,000
Closed -$3.39M
IDYA icon
73
IDEAYA Biosciences
IDYA
$3.56B
– –
-200,000
Closed -$5.14M
IMUX icon
74
Immunic
IMUX
$195M
– –
-456,772
Closed -$4.57M
IMVT icon
75
Immunovant
IMVT
$8.25B
– –
-530,614
Closed -$13.1M
1 2
3
4

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RTW Investments's Q1 2025 Portfolio in Review

As of Q1 2025, RTW Investments held 82 positions worth $6.54B, down 1.1% from $6.61B the previous quarter. Its ten largest holdings account for 53% of the portfolio.

RTW Investments's Q1 2025 filing shows 10 new, 18 increased, 7 reduced and 14 closed positions. Its largest new stake was Intuitive Surgical: 202,456 shares worth $100M. The largest sale was Bruker, an estimated $145M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q1 2025 buy was Intuitive Surgical: 202,456 shares worth $100M.
  • RTW Investments added most to Verona Pharma in Q1 2025, an estimated $61.5M increase.
  • RTW Investments's biggest Q1 2025 reduction was Axsome Therapeutics, cutting an estimated $129M.
  • RTW Investments fully exited Bruker in Q1 2025, selling an estimated $145M.
  • RTW Investments's ten largest holdings make up 53% of its $6.54B portfolio in Q1 2025.
  • RTW Investments opened 10 new positions and closed 14 in Q1 2025.
  • RTW Investments's portfolio value fell 1.1% quarter-over-quarter to $6.54B.

Based on RTW Investments's 13F filing for Q1 2025, filed 15 May 2025.