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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+5.22%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.61B
AUM Growth
-$298M
Cap. Flow
-$123M
Cap. Flow %
-1.86%
Top 10 Hldgs %
48.57%
Holding
77
New
9
Increased
21
Reduced
16
Closed
5

Top Buys

Rank Stock Value
1
GMED icon
Globus Medical
GMED
+$76.7M
2
SYK icon
Stryker
SYK
+$71.6M
3
ZLAB icon
Zai Lab
ZLAB
+$69.6M
4
VRNA
Verona Pharma
VRNA
+$68.4M
5
XNCR icon
Xencor
XNCR
+$42M

Top Sells

Rank Stock Value
1
GERN icon
Geron
GERN
+$200M
2
MASI
Masimo
MASI
+$123M
3
ACAD icon
Acadia Pharmaceuticals
ACAD
+$80.7M
4
BRKR icon
Bruker
BRKR
+$59.1M
5
GKOS icon
Glaukos
GKOS
+$50.3M

Sector Composition

Rank Sector Weight
1 Healthcare 99.89%
2 Financials 0.11%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
DNTH icon
51
Dianthus Therapeutics
DNTH
$6.09B
$14.5M 0.22%
666,667
– –
CRVS icon
52
Corvus Pharmaceuticals
CRVS
$1.17B
$14.3M 0.22%
+2,679,479
New +$20M
IMVT icon
53
Immunovant
IMVT
$8.25B
$13.1M 0.2%
+530,614
New +$15.1M
PEPG icon
54
PepGen
PEPG
$197M
$12.1M 0.18%
+3,193,097
New +$19.9M
CMPS
55
Compass Pathways
CMPS
$1.83B
$11.7M 0.18%
+3,098,987
New +$15.7M
WVE icon
56
Wave Life Sciences
WVE
$1.2B
$11.1M 0.17%
900,000
– –
PCSC
57
DELISTED
Perceptive Capital Solutions
PCSC
$7.56M 0.11%
742,500
– –
XGN icon
58
Exagen
XGN
$166M
$6.2M 0.09%
1,511,866
– –
MIST icon
59
Milestone Pharmaceuticals
MIST
$152M
$5.91M 0.09%
2,506,102
-750,000
-23% -$1.29M
IDYA icon
60
IDEAYA Biosciences
IDYA
$3.56B
$5.14M 0.08%
200,000
– –
IMUX icon
61
Immunic
IMUX
$195M
$4.57M 0.07%
456,772
– –
BIOA
62
BioAge Labs
BIOA
$538M
$4.55M 0.07%
786,353
– –
CBLL
63
CeriBell Inc
CBLL
$714M
$3.88M 0.06%
+150,000
New +$4.09M
GPCR icon
64
Structure Therapeutics
GPCR
$3.78B
$3.39M 0.05%
125,000
– –
SLRN
65
DELISTED
ACELYRIN
SLRN
$3.07M 0.05%
978,310
– –
RGNX icon
66
Regenxbio
RGNX
$708M
$2.71M 0.04%
350,000
– –
EPIX
67
DELISTED
ESSA Pharma
EPIX
$1.99M 0.03%
1,113,002
-2,148,494
-66% -$6.84M
ARTV
68
Artiva Biotherapeutics
ARTV
$551M
$1.5M 0.02%
148,844
– –
ALUR
69
DELISTED
Allurion Technologies
ALUR
$1.27M 0.02%
117,902
-30,000
-20% -$408K
CNTA
70
DELISTED
Centessa Pharmaceuticals
CNTA
$838K 0.01%
50,000
– –
ADGM
71
Adagio Medical Holdings
ADGM
$15.2M
$220K ﹤0.01%
209,361
– –
RCKTW icon
72
Rocket Pharmaceuticals Warrant
RCKTW
$288K
$12K ﹤0.01%
350,000
– –
GERN icon
73
Geron
GERN
$949M
– –
-44,111,916
Closed -$200M
GKOS icon
74
Glaukos
GKOS
$10.6B
– –
-386,291
Closed -$50.3M
SABS icon
75
SAB Biotherapeutics
SABS
$355M
– –
-635,276
Closed -$1.72M
1 2
3
4

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MF
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RTW Investments's Q4 2024 Portfolio in Review

As of Q4 2024, RTW Investments held 77 positions worth $6.61B, down 4.3% from $6.91B the previous quarter. Its ten largest holdings account for 49% of the portfolio.

RTW Investments's Q4 2024 filing shows 9 new, 21 increased, 16 reduced and 5 closed positions. Its largest new stake was Globus Medical: 972,000 shares worth $80.4M. The largest sale was Geron, an estimated $200M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q4 2024 buy was Globus Medical: 972,000 shares worth $80.4M.
  • RTW Investments added most to Stryker in Q4 2024, an estimated $71.6M increase.
  • RTW Investments's biggest Q4 2024 reduction was Masimo, cutting an estimated $123M.
  • RTW Investments fully exited Geron in Q4 2024, selling an estimated $200M.
  • RTW Investments's ten largest holdings make up 49% of its $6.61B portfolio in Q4 2024.
  • RTW Investments opened 9 new positions and closed 5 in Q4 2024.
  • RTW Investments's portfolio value fell 4.3% quarter-over-quarter to $6.61B.

Based on RTW Investments's 13F filing for Q4 2024, filed 14 Feb 2025.