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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+7.37%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.91B
AUM Growth
+$452M
Cap. Flow
+$173M
Cap. Flow %
2.51%
Top 10 Hldgs %
46.12%
Holding
78
New
10
Increased
15
Reduced
10
Closed
10

Top Buys

Rank Stock Value
1
GERN icon
Geron
GERN
+$201M
2
SYK icon
Stryker
SYK
+$137M
3
ORKA
Oruka Therapeutics
ORKA
+$60.3M
4
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$19.9M
5
DYN icon
Dyne Therapeutics
DYN
+$17.2M

Top Sells

Rank Stock Value
1
ISRG icon
Intuitive Surgical
ISRG
+$90.1M
2
RARE icon
Ultragenyx Pharmaceutical
RARE
+$65.8M
3
AXSM icon
Axsome Therapeutics
AXSM
+$38.8M
4
VCEL icon
Vericel Corp
VCEL
+$36.8M
5
FULC icon
Fulcrum Therapeutics
FULC
+$36.2M

Sector Composition

Rank Sector Weight
1 Healthcare 99.89%
2 Financials 0.11%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
XNCR icon
51
Xencor
XNCR
$1.55B
$11.6M 0.17%
+575,000
New +$10.8M
TXG icon
52
10x Genomics
TXG
$6.61B
$11.4M 0.16%
502,856
– –
IMUX icon
53
Immunic
IMUX
$195M
$7.54M 0.11%
456,772
– –
PCSC
54
DELISTED
Perceptive Capital Solutions
PCSC
$7.43M 0.11%
742,500
– –
WVE icon
55
Wave Life Sciences
WVE
$1.2B
$7.38M 0.11%
+900,000
New +$5.38M
IDYA icon
56
IDEAYA Biosciences
IDYA
$3.56B
$6.34M 0.09%
+200,000
New +$7.58M
GPCR icon
57
Structure Therapeutics
GPCR
$3.78B
$5.49M 0.08%
125,000
– –
MIST icon
58
Milestone Pharmaceuticals
MIST
$152M
$4.95M 0.07%
3,256,102
– –
SLRN
59
DELISTED
ACELYRIN
SLRN
$4.82M 0.07%
978,310
– –
XGN icon
60
Exagen
XGN
$166M
$4.67M 0.07%
1,511,866
– –
RGNX icon
61
Regenxbio
RGNX
$708M
$3.67M 0.05%
350,000
– –
ARTV
62
Artiva Biotherapeutics
ARTV
$551M
$2.3M 0.03%
+148,844
New +$1.72M
ALUR
63
DELISTED
Allurion Technologies
ALUR
$2.27M 0.03%
147,902
– –
SABS icon
64
SAB Biotherapeutics
SABS
$355M
$1.72M 0.02%
635,276
-131,670
-17% -$365K
CNTA
65
DELISTED
Centessa Pharmaceuticals
CNTA
$800K 0.01%
+50,000
New +$613K
ADGM
66
Adagio Medical Holdings
ADGM
$15.2M
$540K 0.01%
+209,361
New +$997K
QURE icon
67
uniQure
QURE
$3.22B
$49.3K ﹤0.01%
+10,000
New +$65.1K
RCKTW icon
68
Rocket Pharmaceuticals Warrant
RCKTW
$288K
$22.6K ﹤0.01%
350,000
– –
ACET icon
69
Adicet Bio
ACET
$74.7M
– –
-65,856
Closed -$1.27M
CTMX icon
70
CytomX Therapeutics
CTMX
$754M
– –
-1,200,002
Closed -$1.46M
FULC icon
71
Fulcrum Therapeutics
FULC
$297M
– –
-5,845,956
Closed -$36.2M
ISRG icon
72
Intuitive Surgical
ISRG
$134B
– –
-202,456
Closed -$90.1M
SGMT icon
73
Sagimet Biosciences
SGMT
$559M
– –
-500,000
Closed -$1.71M
VCEL icon
74
Vericel Corp
VCEL
$2.31B
– –
-801,397
Closed -$36.8M
VRDN icon
75
Viridian Therapeutics
VRDN
$2.67B
– –
-605,816
Closed -$7.88M
1 2
3
4

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RTW Investments's Q3 2024 Portfolio in Review

As of Q3 2024, RTW Investments held 78 positions worth $6.91B, up 7% from $6.46B the previous quarter. Its ten largest holdings account for 46% of the portfolio.

RTW Investments's Q3 2024 filing shows 10 new, 15 increased, 10 reduced and 10 closed positions. Its largest new stake was Geron: 44,111,916 shares worth $200M. The largest sale was Intuitive Surgical, an estimated $90.1M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q3 2024 buy was Geron: 44,111,916 shares worth $200M.
  • RTW Investments added most to Oruka Therapeutics in Q3 2024, an estimated $60.3M increase.
  • RTW Investments's biggest Q3 2024 reduction was Ultragenyx Pharmaceutical, cutting an estimated $65.8M.
  • RTW Investments fully exited Intuitive Surgical in Q3 2024, selling an estimated $90.1M.
  • RTW Investments's ten largest holdings make up 46% of its $6.91B portfolio in Q3 2024.
  • RTW Investments opened 10 new positions and closed 10 in Q3 2024.
  • RTW Investments's portfolio value rose 7% quarter-over-quarter to $6.91B.

Based on RTW Investments's 13F filing for Q3 2024, filed 14 Nov 2024.