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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
-6.99%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$4.74B
AUM Growth
-$513M
Cap. Flow
+$325M
Cap. Flow %
6.86%
Top 10 Hldgs %
55.75%
Holding
72
New
10
Increased
16
Reduced
6
Closed
5

Top Buys

Rank Stock Value
1
SAGE
Sage Therapeutics
SAGE
+$149M
2
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$82M
3
ACAD icon
Acadia Pharmaceuticals
ACAD
+$48.7M
4
APGE icon
Apogee Therapeutics
APGE
+$47.2M
5
TSHA icon
Taysha Gene Therapies
TSHA
+$31.6M

Top Sells

Rank Stock Value
1
HZNP
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
+$103M
2
ISRG icon
Intuitive Surgical
ISRG
+$58.1M
3
ILMN icon
Illumina
ILMN
+$31.8M
4
AXNX
Axonics, Inc. Common Stock
AXNX
+$24.9M
5
MRVI icon
Maravai LifeSciences
MRVI
+$19.1M

Sector Composition

Rank Sector Weight
1 Healthcare 99.97%
2 Financials 0.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SYK icon
51
Stryker
SYK
$130B
$7.65M 0.16%
+28,000
New +$8.03M
RLMD icon
52
Relmada Therapeutics
RLMD
$527M
$6.4M 0.13%
2,131,835
– –
IMUX icon
53
Immunic
IMUX
$195M
$6.37M 0.13%
433,526
+4,080
+1% +$78.4K
DSGN icon
54
Design Therapeutics
DSGN
$876M
$5.93M 0.13%
2,512,986
+949,955
+61% +$4.43M
ACET icon
55
Adicet Bio
ACET
$74.7M
$5.81M 0.12%
265,092
– –
APYX icon
56
Apyx Medical
APYX
$171M
$5.69M 0.12%
1,777,194
– –
DMTK
57
DELISTED
DermTech, Inc. Common Stock
DMTK
$3.91M 0.08%
2,718,356
– –
XGN icon
58
Exagen
XGN
$166M
$3.61M 0.08%
1,492,432
– –
SGMT icon
59
Sagimet Biosciences
SGMT
$559M
$3.52M 0.07%
+400,277
New +$5.33M
VKTX icon
60
Viking Therapeutics
VKTX
$4B
$2.87M 0.06%
259,400
-740,600
-74% -$10.6M
OLK
61
DELISTED
Olink Holding AB (publ) American Depositary Shares
OLK
$2.41M 0.05%
163,652
-490,960
-75% -$8.22M
AKYA
62
DELISTED
Akoya BioSciences
AKYA
$1.57M 0.03%
338,422
– –
ARYD
63
DELISTED
ARYA Sciences Acquisition Corp IV Class A Odinary Shares
ARYD
$1.38M 0.03%
127,970
– –
RYZB
64
DELISTED
RayzeBio, Inc. Common Stock
RYZB
$1.03M 0.02%
+46,300
New +$972K
SIEN
65
DELISTED
Sientra, Inc.
SIEN
$845K 0.02%
+304,036
New +$936K
MIRO
66
DELISTED
Miromatrix Medical Inc. Common Stock
MIRO
$583K 0.01%
445,222
– –
RCKTW icon
67
Rocket Pharmaceuticals Warrant
RCKTW
$288K
$59.5K ﹤0.01%
350,000
– –
BDTX icon
68
Black Diamond Therapeutics
BDTX
$112M
– –
-1,700,000
Closed -$8.59M
ISRG icon
69
Intuitive Surgical
ISRG
$134B
– –
-170,000
Closed -$58.1M
MRSN
70
DELISTED
Mersana Therapeutics
MRSN
– –
-24,594
Closed -$2.02M
MRVI icon
71
Maravai LifeSciences
MRVI
$919M
– –
-1,532,685
Closed -$19.1M
HZNP
72
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
– –
-1,000,000
Closed -$103M
1 2
3

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HRCM
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RA
Royce & Associates New York $10.1B AUM 42.88% 1-Year Est. Return
GI
GAMCO Investors Greenwich, Connecticut $10.2B AUM 30.27% 1-Year Est. Return
IIM
INTECH Investment Management West Palm Beach, Florida $10.2B AUM 28.14% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
VPIM
Vanguard Personalized Indexing Management Oakland, California $10.2B AUM 34.45% 1-Year Est. Return
HI
HBK Investments Dallas, Texas $9.85B AUM 55.6% 1-Year Est. Return
MF
Magnetar Financial Evanston, Illinois $9.84B AUM 190.63% 1-Year Est. Return

RTW Investments's Q3 2023 Portfolio in Review

As of Q3 2023, RTW Investments held 72 positions worth $4.74B, down 9.8% from $5.25B the previous quarter. Its ten largest holdings account for 56% of the portfolio.

RTW Investments deployed $325M of net new capital in Q3 2023, opening 10 new positions and adding to 16 existing holdings. Its largest new stake was Sage Therapeutics: 5,149,482 shares worth $106M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was Illumina, an estimated $31.8M trimmed.

  • RTW Investments's largest Q3 2023 buy was Sage Therapeutics: 5,149,482 shares worth $106M.
  • RTW Investments added most to Mirati Therapeutics, Inc. Common Stock in Q3 2023, an estimated $82M increase.
  • RTW Investments's biggest Q3 2023 reduction was Illumina, cutting an estimated $31.8M.
  • RTW Investments fully exited Horizon Therapeutics Public Limited Company Ordinary Shares in Q3 2023, selling an estimated $103M.
  • RTW Investments's ten largest holdings make up 56% of its $4.74B portfolio in Q3 2023.
  • RTW Investments opened 10 new positions and closed 5 in Q3 2023.
  • RTW Investments's portfolio value fell 9.8% quarter-over-quarter to $4.74B.

Based on RTW Investments's 13F filing for Q3 2023, filed 14 Nov 2023.