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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+18.13%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$4.9B
AUM Growth
+$561M
Cap. Flow
+$279M
Cap. Flow %
5.7%
Top 10 Hldgs %
55.22%
Holding
87
New
1
Increased
20
Reduced
10
Closed
10

Top Buys

Rank Stock Value
1
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$114M
2
AXSM icon
Axsome Therapeutics
AXSM
+$65.6M
3
RARE icon
Ultragenyx Pharmaceutical
RARE
+$63.2M
4
IMCR icon
Immunocore
IMCR
+$62.4M
5
RCKT icon
Rocket Pharmaceuticals
RCKT
+$34.7M

Top Sells

Rank Stock Value
1
ISEE
IVERIC bio, Inc. Common Stock
ISEE
+$59.8M
2
TSVT
2seventy bio
TSVT
+$17.9M
3
TNDM icon
Tandem Diabetes Care
TNDM
+$15.4M
4
GH icon
Guardant Health
GH
+$13.5M
5
RCOR
Renovacor, Inc.
RCOR
+$7.56M

Sector Composition

Rank Sector Weight
1 Healthcare 99.63%
2 Financials 0.27%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
APYX icon
51
Apyx Medical
APYX
$171M
$7.95M 0.16%
3,398,279
– –
URGN icon
52
UroGen Pharma
URGN
$2.29B
$7.61M 0.16%
857,464
– –
IMTX icon
53
Immatics
IMTX
$1.32B
$7.36M 0.15%
845,000
+495,000
+141% +$5.12M
RLMD icon
54
Relmada Therapeutics
RLMD
$527M
$7.22M 0.15%
2,067,824
-576,651
-22% -$5.06M
ROIV icon
55
Roivant Sciences
ROIV
$26.2B
$6.41M 0.13%
802,717
– –
JNCE
56
DELISTED
Jounce Therapeutics, Inc. Common Stock
JNCE
$5.67M 0.12%
5,106,341
– –
IMUX icon
57
Immunic
IMUX
$195M
$5.41M 0.11%
386,129
+109,932
+40% +$3M
MLTX icon
58
MoonLake Immunotherapeutics
MLTX
$1.55B
$5.25M 0.11%
500,000
– –
SMIHU
59
DELISTED
Summit Healthcare Acquisition Corp. Units
SMIHU
$5.06M 0.1%
500,000
– –
ARYD
60
DELISTED
ARYA Sciences Acquisition Corp IV Class A Odinary Shares
ARYD
$5.05M 0.1%
500,000
– –
ARYE
61
DELISTED
ARYA Sciences Acquisition Corp V Class A Ordinary Shares
ARYE
$5.04M 0.1%
500,000
– –
TNYA icon
62
Tenaya Therapeutics
TNYA
$163M
$4.94M 0.1%
2,458,750
– –
DMTK
63
DELISTED
DermTech, Inc. Common Stock
DMTK
$4.81M 0.1%
2,718,356
-400,310
-13% -$1.06M
AKYA
64
DELISTED
Akoya BioSciences
AKYA
$4.63M 0.09%
483,815
– –
TELA icon
65
TELA Bio
TELA
$38.9M
$4.49M 0.09%
390,364
– –
BWAY
66
Brainsway
BWAY
$622M
$3.96M 0.08%
3,204,762
– –
XGN icon
67
Exagen
XGN
$166M
$3.27M 0.07%
1,364,336
+315,674
+30% +$810K
JNJ icon
68
Johnson & Johnson
JNJ
$625B
$3.2M 0.07%
18,127
– –
MSAC
69
DELISTED
Medicus Sciences Acquisition Corp. Class A Ordinary Share
MSAC
$3.02M 0.06%
300,000
– –
THRD
70
DELISTED
Third Harmonic Bio
THRD
$2.62M 0.05%
609,687
– –
MASS icon
71
908 Devices
MASS
$364M
$2.38M 0.05%
312,000
– –
LUNG icon
72
Pulmonx
LUNG
$87.6M
$2.32M 0.05%
275,000
-185,847
-40% -$1.77M
NYXH
73
Nyxoah
NYXH
$147M
$1.35M 0.03%
269,993
-74,918
-22% -$425K
NAUT icon
74
Nautilus Biotechnolgy
NAUT
$115M
$1.08M 0.02%
600,000
– –
SNCE
75
DELISTED
Science 37 Holdings, Inc. Common Stock
SNCE
$1.07M 0.02%
129,305
-87,114
-40% -$1.7M
1 2
3
4

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RTW Investments's Q4 2022 Portfolio in Review

As of Q4 2022, RTW Investments held 87 positions worth $4.9B, up 13% from $4.34B the previous quarter. Its ten largest holdings account for 55% of the portfolio.

RTW Investments deployed $279M of net new capital in Q4 2022, opening 1 new position and adding to 20 existing holdings. Its largest new stake was Terns Pharmaceuticals: 1,000,000 shares worth $10.2M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 99% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was IVERIC bio, Inc. Common Stock, an estimated $59.8M trimmed.

  • RTW Investments's largest Q4 2022 buy was Terns Pharmaceuticals: 1,000,000 shares worth $10.2M.
  • RTW Investments added most to Mirati Therapeutics, Inc. Common Stock in Q4 2022, an estimated $114M increase.
  • RTW Investments's biggest Q4 2022 reduction was IVERIC bio, Inc. Common Stock, cutting an estimated $59.8M.
  • RTW Investments fully exited 2seventy bio in Q4 2022, selling an estimated $17.9M.
  • RTW Investments's ten largest holdings make up 55% of its $4.9B portfolio in Q4 2022.
  • RTW Investments opened 1 new position and closed 10 in Q4 2022.
  • RTW Investments's portfolio value rose 13% quarter-over-quarter to $4.9B.

Based on RTW Investments's 13F filing for Q4 2022, filed 14 Feb 2023.