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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+2.62%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.41B
AUM Growth
+$445M
Cap. Flow
+$949M
Cap. Flow %
14.82%
Top 10 Hldgs %
42.9%
Holding
120
New
18
Increased
32
Reduced
16
Closed
9

Top Buys

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$365M
2
QDEL icon
QuidelOrtho
QDEL
+$162M
3
RXDX
Prometheus Biosciences, Inc. Common Stock
RXDX
+$67.4M
4
PTCT icon
PTC Therapeutics
PTCT
+$63.7M
5
ITOS
iTeos Therapeutics
ITOS
+$61M

Top Sells

Rank Stock Value
1
KRRO icon
Korro Bio
KRRO
+$86.8M
2
RCKT icon
Rocket Pharmaceuticals
RCKT
+$73.8M
3
FPRX
Five Prime Therapeutics, Inc.
FPRX
+$42.8M
4
IMVT icon
Immunovant
IMVT
+$32.6M
5
PEN icon
Penumbra
PEN
+$20.7M

Sector Composition

Rank Sector Weight
1 Healthcare 88.33%
2 Financials 0.35%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
OYST
51
DELISTED
Oyster Point Pharma, Inc. Common Stock
OYST
$34M 0.53%
1,861,209
-64,385
-3% -$1.35M
APYX icon
52
Apyx Medical
APYX
$171M
$32.8M 0.51%
3,391,279
– –
KURA icon
53
Kura Oncology
KURA
$850M
$30.6M 0.48%
1,081,912
-619,869
-36% -$19.6M
XGN icon
54
Exagen
XGN
$166M
$28.5M 0.44%
1,626,365
+376,234
+30% +$6.7M
JNJ icon
55
Johnson & Johnson
JNJ
$625B
$28M 0.44%
170,542
+20,781
+14% +$3.36M
MDXG icon
56
MiMedx Group
MDXG
$633M
$27.8M 0.43%
2,700,320
– –
MIST icon
57
Milestone Pharmaceuticals
MIST
$152M
$25M 0.39%
4,315,102
– –
TRIL
58
DELISTED
Trillium Therapeutics Inc.
TRIL
$22.5M 0.35%
2,091,389
-73,808
-3% -$913K
TELA icon
59
TELA Bio
TELA
$38.9M
$20.6M 0.32%
1,382,343
-1,473
-0.1% -$22.2K
ABUS icon
60
Arbutus Biopharma
ABUS
$915M
$19.9M 0.31%
5,978,355
– –
BLU
61
DELISTED
BELLUS Health Inc.
BLU
$19M 0.3%
4,968,017
-221,845
-4% -$842K
PMVP icon
62
PMV Pharmaceuticals
PMVP
$63.5M
$15.9M 0.25%
484,133
-16,749
-3% -$660K
IMUX icon
63
Immunic
IMUX
$195M
$14.7M 0.23%
92,081
– –
BWAY
64
Brainsway
BWAY
$622M
$14.5M 0.23%
3,204,362
+997,414
+45% +$4.32M
RGNX icon
65
Regenxbio
RGNX
$708M
$14.2M 0.22%
416,577
+134,317
+48% +$5.73M
CELL
66
DELISTED
PhenomeX Inc. Common Stock
CELL
$12.9M 0.2%
257,546
-67,188
-21% -$4.58M
CTMX icon
67
CytomX Therapeutics
CTMX
$754M
$11.9M 0.19%
1,533,758
+6,406
+0.4% +$50.7K
ASLN
68
DELISTED
ASLAN Pharmaceuticals Limited American Depositary Shares
ASLN
$10.9M 0.17%
+81,250
New +$10.3M
CLSD
69
DELISTED
Clearside Biomedical
CLSD
$10.4M 0.16%
280,451
+16,576
+6% +$832K
LJPC
70
DELISTED
La Jolla Pharmaceutical Company
LJPC
$9.87M 0.15%
2,327,903
-69,475
-3% -$383K
VINC
71
DELISTED
Vincerx Pharma, Inc. Common Stock
VINC
$9.65M 0.15%
25,000
– –
INMD icon
72
InMode
INMD
$880M
$9.05M 0.14%
249,998
– –
ARGX icon
73
argenx
ARGX
$54.1B
$8.74M 0.14%
31,752
– –
APVO icon
74
Aptevo Therapeutics
APVO
$5.21M
– –
0
– –
RCOR
75
DELISTED
Renovacor, Inc.
RCOR
$8.42M 0.13%
+837,540
New +$8.67M
1 2
3
4 5

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RTW Investments's Q1 2021 Portfolio in Review

As of Q1 2021, RTW Investments held 120 positions worth $6.41B, up 7.5% from $5.96B the previous quarter. Its ten largest holdings account for 43% of the portfolio.

RTW Investments deployed $949M of net new capital in Q1 2021, opening 18 new positions and adding to 32 existing holdings. Its largest new stake was State Street SPDR S&P 500 ETF Trust: 946,255 shares worth $375M.

By sector, the portfolio is most concentrated in Healthcare at 88% of assets, down from 94% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was Rocket Pharmaceuticals, an estimated $73.8M trimmed.

  • RTW Investments's largest Q1 2021 buy was State Street SPDR S&P 500 ETF Trust: 946,255 shares worth $375M.
  • RTW Investments added most to PTC Therapeutics in Q1 2021, an estimated $63.7M increase.
  • RTW Investments's biggest Q1 2021 reduction was Rocket Pharmaceuticals, cutting an estimated $73.8M.
  • RTW Investments fully exited Korro Bio in Q1 2021, selling an estimated $86.8M.
  • RTW Investments's ten largest holdings make up 43% of its $6.41B portfolio in Q1 2021.
  • RTW Investments opened 18 new positions and closed 9 in Q1 2021.
  • RTW Investments's portfolio value rose 7.5% quarter-over-quarter to $6.41B.

Based on RTW Investments's 13F filing for Q1 2021, filed 14 May 2021.