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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+60.02%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$5.96B
AUM Growth
+$1.81B
Cap. Flow
+$286M
Cap. Flow %
4.79%
Top 10 Hldgs %
47.57%
Holding
116
New
25
Increased
35
Reduced
12
Closed
14

Top Buys

Rank Stock Value
1
GMED icon
Globus Medical
GMED
+$94.3M
2
TARS icon
Tarsus Pharmaceuticals
TARS
+$70.2M
3
CCCC icon
C4 Therapeutics
CCCC
+$62.3M
4
ARVN icon
Arvinas
ARVN
+$61.8M
5
ILMN icon
Illumina
ILMN
+$61.2M

Top Sells

Rank Stock Value
1
MYOK
MyoKardia, Inc. Common Stock
MYOK
+$128M
2
BAX icon
Baxter International
BAX
+$86.6M
3
INCY icon
Incyte
INCY
+$30M
4
QTTB icon
Q32 Bio
QTTB
+$26.9M
5
OSUR icon
OraSure Technologies
OSUR
+$24.8M

Sector Composition

Rank Sector Weight
1 Healthcare 94%
2 Financials 0.18%
3 Materials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MDXG icon
51
MiMedx Group
MDXG
$633M
$24.5M 0.41%
2,700,320
– –
APYX icon
52
Apyx Medical
APYX
$171M
$24.4M 0.41%
3,391,279
– –
FULC icon
53
Fulcrum Therapeutics
FULC
$297M
$24.3M 0.41%
2,071,409
+920,844
+80% +$10.4M
JNJ icon
54
Johnson & Johnson
JNJ
$625B
$23.6M 0.4%
149,761
– –
ABUS icon
55
Arbutus Biopharma
ABUS
$915M
$21.2M 0.36%
5,978,355
– –
PRQR icon
56
ProQR Therapeutics
PRQR
$265M
$21M 0.35%
5,009,768
+36,594
+0.7% +$154K
TELA icon
57
TELA Bio
TELA
$38.9M
$20.8M 0.35%
1,383,816
+5,040
+0.4% +$81.8K
PEN icon
58
Penumbra
PEN
$12.8B
$20.7M 0.35%
+118,273
New +$25.9M
ODT
59
DELISTED
Odonate Therapeutics, Inc. Common Stock
ODT
$19.2M 0.32%
1,000,139
+883
+0.1% +$13.6K
XGN icon
60
Exagen
XGN
$166M
$16.5M 0.28%
1,250,131
– –
BLU
61
DELISTED
BELLUS Health Inc.
BLU
$15.8M 0.26%
5,189,862
+994,506
+24% +$2.69M
IMUX icon
62
Immunic
IMUX
$195M
$14.1M 0.24%
92,081
+831
+0.9% +$149K
AFIB
63
DELISTED
Acutus Medical Inc
AFIB
$13M 0.22%
451,834
– –
RGNX icon
64
Regenxbio
RGNX
$708M
$12.8M 0.21%
282,260
-36,174
-11% -$1.26M
GNMK
65
DELISTED
GenMark Diagnostics, Inc
GNMK
$11.1M 0.19%
762,994
– –
CLSD
66
DELISTED
Clearside Biomedical
CLSD
$10.8M 0.18%
263,875
+707
+0.3% +$18.3K
APVO icon
67
Aptevo Therapeutics
APVO
$5.21M
– –
0
– –
VINC
68
DELISTED
Vincerx Pharma, Inc. Common Stock
VINC
$10.5M 0.18%
+25,000
New +$7.88M
CTMX icon
69
CytomX Therapeutics
CTMX
$754M
$10M 0.17%
1,527,352
+1,349
+0.1% +$9.64K
ARGX icon
70
argenx
ARGX
$54.1B
$9.34M 0.16%
31,752
– –
LJPC
71
DELISTED
La Jolla Pharmaceutical Company
LJPC
$9.3M 0.16%
2,397,378
+2,349
+0.1% +$10K
MLTX icon
72
MoonLake Immunotherapeutics
MLTX
$1.55B
$8.53M 0.14%
+750,000
New +$7.96M
BWAY
73
Brainsway
BWAY
$622M
$8.32M 0.14%
2,206,948
-7,892
-0.4% -$24.1K
CERE
74
DELISTED
Cerevel Therapeutics Holdings, Inc. Common Stock
CERE
$8.29M 0.14%
+500,000
New +$6.49M
SRRK icon
75
Scholar Rock
SRRK
$6.44B
$8.06M 0.14%
+166,183
New +$6.03M
1 2
3
4 5

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RTW Investments's Q4 2020 Portfolio in Review

As of Q4 2020, RTW Investments held 116 positions worth $5.96B, up 44% from $4.15B the previous quarter. Its ten largest holdings account for 48% of the portfolio.

RTW Investments deployed $286M of net new capital in Q4 2020, opening 25 new positions and adding to 35 existing holdings. Its largest new stake was Globus Medical: 1,640,859 shares worth $107M.

By sector, the portfolio is most concentrated in Healthcare at 94% of assets, up from 93% a quarter earlier, followed by Financials and Materials.

On the sell side, the largest reduction was OraSure Technologies, an estimated $24.8M trimmed.

  • RTW Investments's largest Q4 2020 buy was Globus Medical: 1,640,859 shares worth $107M.
  • RTW Investments added most to Illumina in Q4 2020, an estimated $61.2M increase.
  • RTW Investments's biggest Q4 2020 reduction was OraSure Technologies, cutting an estimated $24.8M.
  • RTW Investments fully exited MyoKardia, Inc. Common Stock in Q4 2020, selling an estimated $128M.
  • RTW Investments's ten largest holdings make up 48% of its $5.96B portfolio in Q4 2020.
  • RTW Investments opened 25 new positions and closed 14 in Q4 2020.
  • RTW Investments's portfolio value rose 44% quarter-over-quarter to $5.96B.

Based on RTW Investments's 13F filing for Q4 2020, filed 16 Feb 2021.