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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
-6.99%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$4.74B
AUM Growth
-$513M
Cap. Flow
+$325M
Cap. Flow %
6.86%
Top 10 Hldgs %
55.75%
Holding
72
New
10
Increased
16
Reduced
6
Closed
5

Top Buys

Rank Stock Value
1
SAGE
Sage Therapeutics
SAGE
+$149M
2
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$82M
3
ACAD icon
Acadia Pharmaceuticals
ACAD
+$48.7M
4
APGE icon
Apogee Therapeutics
APGE
+$47.2M
5
TSHA icon
Taysha Gene Therapies
TSHA
+$31.6M

Top Sells

Rank Stock Value
1
HZNP
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
+$103M
2
ISRG icon
Intuitive Surgical
ISRG
+$58.1M
3
ILMN icon
Illumina
ILMN
+$31.8M
4
AXNX
Axonics, Inc. Common Stock
AXNX
+$24.9M
5
MRVI icon
Maravai LifeSciences
MRVI
+$19.1M

Sector Composition

Rank Sector Weight
1 Healthcare 99.97%
2 Financials 0.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
INSM icon
26
Insmed
INSM
$28.6B
$47.1M 0.99%
1,865,108
+865,108
+87% +$19.8M
MRUS
27
DELISTED
Merus
MRUS
$47.1M 0.99%
1,996,764
+945,871
+90% +$22.9M
APGE icon
28
Apogee Therapeutics
APGE
$10.2B
$45.6M 0.96%
+2,142,591
New +$47.2M
MDGL icon
29
Madrigal Pharmaceuticals
MDGL
$11.8B
$45.2M 0.95%
309,485
+87,923
+40% +$16.5M
RNAM
30
DELISTED
Avidity Biosciences
RNAM
$42.7M 0.9%
6,689,789
– –
GHRS icon
31
GH Research
GHRS
$2.08B
$33.4M 0.71%
3,327,129
+1,158,172
+53% +$13.4M
MLTX icon
32
MoonLake Immunotherapeutics
MLTX
$1.55B
$28.5M 0.6%
500,000
– –
FULC icon
33
Fulcrum Therapeutics
FULC
$297M
$25.8M 0.55%
5,818,804
-245,319
-4% -$1.07M
ILMN icon
34
Illumina
ILMN
$28.4B
$25.8M 0.54%
193,393
-193,392
-50% -$31.8M
ALKS icon
35
Alkermes
ALKS
$8.25B
$24.9M 0.53%
+889,073
New +$26.1M
AXNX
36
DELISTED
Axonics, Inc. Common Stock
AXNX
$24.8M 0.52%
442,487
-442,487
-50% -$24.9M
SWAV
37
DELISTED
Shockwave Medical, Inc. Common Stock
SWAV
$24.7M 0.52%
+124,000
New +$29.3M
SCPH
38
DELISTED
scPharmaceuticals
SCPH
$23.5M 0.5%
3,297,843
– –
ROIV icon
39
Roivant Sciences
ROIV
$26.2B
$18.1M 0.38%
1,552,717
– –
STOK icon
40
Stoke Therapeutics
STOK
$2.11B
$17.3M 0.37%
4,390,558
– –
ALUR
41
DELISTED
Allurion Technologies
ALUR
$14.9M 0.31%
+138,308
New +$15.6M
GH icon
42
Guardant Health
GH
$22.6B
$14.8M 0.31%
500,887
– –
PMVP icon
43
PMV Pharmaceuticals
PMVP
$63.5M
$14.6M 0.31%
2,375,785
-653,766
-22% -$4.5M
URGN icon
44
UroGen Pharma
URGN
$2.29B
$12M 0.25%
857,464
– –
CUTR
45
DELISTED
Cutera, Inc.
CUTR
$11.1M 0.23%
1,846,596
– –
MIST icon
46
Milestone Pharmaceuticals
MIST
$152M
$10.1M 0.21%
3,256,102
– –
SLRN
47
DELISTED
ACELYRIN
SLRN
$9.95M 0.21%
978,310
– –
IMTX icon
48
Immatics
IMTX
$1.32B
$9.79M 0.21%
845,000
– –
OM icon
49
Outset Medical
OM
$90.8M
$8.8M 0.19%
53,911
– –
MLYS icon
50
Mineralys Therapeutics
MLYS
$2.41B
$8.77M 0.19%
922,100
– –
1
2
3

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RA
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GI
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IIM
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ACA
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VPIM
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HI
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MF
Magnetar Financial Evanston, Illinois $9.84B AUM 190.63% 1-Year Est. Return

RTW Investments's Q3 2023 Portfolio in Review

As of Q3 2023, RTW Investments held 72 positions worth $4.74B, down 9.8% from $5.25B the previous quarter. Its ten largest holdings account for 56% of the portfolio.

RTW Investments deployed $325M of net new capital in Q3 2023, opening 10 new positions and adding to 16 existing holdings. Its largest new stake was Sage Therapeutics: 5,149,482 shares worth $106M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, down from 100% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was Illumina, an estimated $31.8M trimmed.

  • RTW Investments's largest Q3 2023 buy was Sage Therapeutics: 5,149,482 shares worth $106M.
  • RTW Investments added most to Mirati Therapeutics, Inc. Common Stock in Q3 2023, an estimated $82M increase.
  • RTW Investments's biggest Q3 2023 reduction was Illumina, cutting an estimated $31.8M.
  • RTW Investments fully exited Horizon Therapeutics Public Limited Company Ordinary Shares in Q3 2023, selling an estimated $103M.
  • RTW Investments's ten largest holdings make up 56% of its $4.74B portfolio in Q3 2023.
  • RTW Investments opened 10 new positions and closed 5 in Q3 2023.
  • RTW Investments's portfolio value fell 9.8% quarter-over-quarter to $4.74B.

Based on RTW Investments's 13F filing for Q3 2023, filed 14 Nov 2023.