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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+5.65%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$4.8B
AUM Growth
-$96.5M
Cap. Flow
+$4.8M
Cap. Flow %
0.1%
Top 10 Hldgs %
55.46%
Holding
84
New
7
Increased
20
Reduced
15
Closed
24

Top Buys

Rank Stock Value
1
ACAD icon
Acadia Pharmaceuticals
ACAD
+$87.1M
2
BRKR icon
Bruker
BRKR
+$85.7M
3
PTCT icon
PTC Therapeutics
PTCT
+$67.6M
4
AXSM icon
Axsome Therapeutics
AXSM
+$52.6M
5
OBIO icon
Orchestra BioMed
OBIO
+$47.7M

Top Sells

Rank Stock Value
1
TMO icon
Thermo Fisher Scientific
TMO
+$81.8M
2
GMED icon
Globus Medical
GMED
+$55.5M
3
RGNX icon
Regenxbio
RGNX
+$41.9M
4
ILMN icon
Illumina
ILMN
+$39.6M
5
BCYC
Bicycle Therapeutics
BCYC
+$37.3M

Sector Composition

Rank Sector Weight
1 Healthcare 99.97%
2 Financials 0.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
AXNX
26
DELISTED
Axonics, Inc. Common Stock
AXNX
$48.3M 1.01%
884,974
– –
VTYX
27
DELISTED
Ventyx Biosciences
VTYX
$46.5M 0.97%
1,388,881
-162,897
-10% -$6.33M
CUTR
28
DELISTED
Cutera, Inc.
CUTR
$43.6M 0.91%
1,846,596
+47,921
+3% +$1.53M
STOK icon
29
Stoke Therapeutics
STOK
$2.11B
$36.6M 0.76%
4,390,558
+519,577
+13% +$4.69M
TARS icon
30
Tarsus Pharmaceuticals
TARS
$2.84B
$32M 0.67%
2,548,125
– –
SCPH
31
DELISTED
scPharmaceuticals
SCPH
$29.9M 0.62%
+3,297,843
New +$24.2M
ACET icon
32
Adicet Bio
ACET
$74.7M
$24.4M 0.51%
265,092
– –
GHRS icon
33
GH Research
GHRS
$2.08B
$17.3M 0.36%
2,168,957
– –
VKTX icon
34
Viking Therapeutics
VKTX
$4B
$16.6M 0.35%
+1,000,000
New +$10.3M
FULC icon
35
Fulcrum Therapeutics
FULC
$297M
$15.7M 0.33%
5,511,839
+518,560
+10% +$4.65M
OM icon
36
Outset Medical
OM
$90.8M
$14.9M 0.31%
53,911
-6,732
-11% -$2.47M
OLK
37
DELISTED
Olink Holding AB (publ) American Depositary Shares
OLK
$14.7M 0.31%
654,612
-327,306
-33% -$7.13M
MLYS icon
38
Mineralys Therapeutics
MLYS
$2.41B
$14.4M 0.3%
+922,100
New +$15.5M
PMVP icon
39
PMV Pharmaceuticals
PMVP
$63.5M
$14.3M 0.3%
2,999,098
-1,357,822
-31% -$9.56M
MIST icon
40
Milestone Pharmaceuticals
MIST
$152M
$12.8M 0.27%
3,256,102
-1,059,000
-25% -$3.87M
ROIV icon
41
Roivant Sciences
ROIV
$26.2B
$11.5M 0.24%
1,552,717
+750,000
+93% +$6.18M
MLTX icon
42
MoonLake Immunotherapeutics
MLTX
$1.55B
$10.7M 0.22%
500,000
– –
GH icon
43
Guardant Health
GH
$22.6B
$10.1M 0.21%
430,887
– –
DMTK
44
DELISTED
DermTech, Inc. Common Stock
DMTK
$10M 0.21%
2,718,356
– –
APYX icon
45
Apyx Medical
APYX
$171M
$9.79M 0.2%
3,398,279
– –
URGN icon
46
UroGen Pharma
URGN
$2.29B
$7.92M 0.17%
857,464
– –
IMUX icon
47
Immunic
IMUX
$195M
$6.4M 0.13%
429,446
+43,317
+11% +$804K
ALLK
48
DELISTED
Allakos
ALLK
$5.9M 0.12%
1,326,608
-316,892
-19% -$2.03M
CSTL icon
49
Castle Biosciences
CSTL
$979M
$5.87M 0.12%
258,498
-258,497
-50% -$6.32M
IMTX icon
50
Immatics
IMTX
$1.32B
$5.83M 0.12%
845,000
– –
1
2
3 4

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RTW Investments's Q1 2023 Portfolio in Review

As of Q1 2023, RTW Investments held 84 positions worth $4.8B, down 2% from $4.9B the previous quarter. Its ten largest holdings account for 55% of the portfolio.

RTW Investments's Q1 2023 filing shows 7 new, 20 increased, 15 reduced and 24 closed positions. Its largest new stake was Bruker: 1,187,342 shares worth $93.6M. The largest sale was Thermo Fisher Scientific, an estimated $81.8M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q1 2023 buy was Bruker: 1,187,342 shares worth $93.6M.
  • RTW Investments added most to Acadia Pharmaceuticals in Q1 2023, an estimated $87.1M increase.
  • RTW Investments's biggest Q1 2023 reduction was Thermo Fisher Scientific, cutting an estimated $81.8M.
  • RTW Investments fully exited Globus Medical in Q1 2023, selling an estimated $55.5M.
  • RTW Investments's ten largest holdings make up 55% of its $4.8B portfolio in Q1 2023.
  • RTW Investments opened 7 new positions and closed 24 in Q1 2023.
  • RTW Investments's portfolio value fell 2% quarter-over-quarter to $4.8B.

Based on RTW Investments's 13F filing for Q1 2023, filed 15 May 2023.