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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+9.72%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.63B
AUM Growth
+$221M
Cap. Flow
-$85.5M
Cap. Flow %
-1.29%
Top 10 Hldgs %
45.03%
Holding
125
New
14
Increased
22
Reduced
8
Closed
12

Top Buys

Rank Stock Value
1
EPIX
ESSA Pharma
EPIX
+$80.5M
2
MASI
Masimo
MASI
+$52.8M
3
RGNX icon
Regenxbio
RGNX
+$48M
4
GHRS icon
GH Research
GHRS
+$44.3M
5
GH icon
Guardant Health
GH
+$41.5M

Top Sells

Rank Stock Value
1
CERN
Cerner Corp
CERN
+$128M
2
ARVN icon
Arvinas
ARVN
+$107M
3
IMVT icon
Immunovant
IMVT
+$102M
4
TBIO
Translate Bio, Inc. Common Stock
TBIO
+$72.3M
5
CRIS icon
Curis
CRIS
+$41M

Sector Composition

Rank Sector Weight
1 Healthcare 88.48%
2 Financials 0.38%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
RXDX
26
DELISTED
Prometheus Biosciences, Inc. Common Stock
RXDX
$76M 1.15%
3,264,031
– –
IDYA icon
27
IDEAYA Biosciences
IDYA
$3.49B
$68.6M 1.03%
3,266,255
+800,000
+32% +$16.4M
MGNX icon
28
MacroGenics
MGNX
$255M
$68.4M 1.03%
2,546,925
+532,525
+26% +$15.6M
RGNX icon
29
Regenxbio
RGNX
$722M
$68.3M 1.03%
1,757,743
+1,341,166
+322% +$48M
AGEN
30
Agenus
AGEN
$312M
$62.8M 0.95%
582,727
-119,224
-17% -$8.94M
CSTL icon
31
Castle Biosciences
CSTL
$931M
$58.6M 0.88%
799,009
– –
TARS icon
32
Tarsus Pharmaceuticals
TARS
$2.85B
$58.4M 0.88%
2,013,601
-450,000
-18% -$14.1M
NSTG
33
DELISTED
NanoString Technologies, Inc.
NSTG
$52.1M 0.79%
804,029
– –
LUNG icon
34
Pulmonx
LUNG
$88M
$49.8M 0.75%
1,129,600
– –
RLMD icon
35
Relmada Therapeutics
RLMD
$564M
$49.2M 0.74%
1,538,026
+7,309
+0.5% +$254K
LABP
36
DELISTED
Landos Biopharma, Inc. Common Stock
LABP
$48.5M 0.73%
427,572
– –
IMCR icon
37
Immunocore
IMCR
$1.75B
$47.9M 0.72%
1,245,532
– –
ITOS
38
DELISTED
iTeos Therapeutics
ITOS
$44M 0.66%
1,716,585
-1,046,206
-38% -$24.9M
PRQR icon
39
ProQR Therapeutics
PRQR
$268M
$43.4M 0.66%
6,443,113
+19,035
+0.3% +$123K
OLK
40
DELISTED
Olink Holding AB (publ) American Depositary Shares
OLK
$43M 0.65%
1,248,188
+1,062,350
+572% +$36.5M
GHRS icon
41
GH Research
GHRS
$2.1B
$42.7M 0.64%
+2,168,957
New +$44.3M
ISEE
42
DELISTED
IVERIC bio, Inc. Common Stock
ISEE
$42.4M 0.64%
6,722,624
– –
CYTK icon
43
Cytokinetics
CYTK
$11B
$39.6M 0.6%
2,000,000
– –
AVDL
44
DELISTED
Avadel Pharmaceuticals
AVDL
$38.6M 0.58%
5,741,939
– –
OM icon
45
Outset Medical
OM
$96.4M
$36.8M 0.56%
49,143
+3,333
+7% +$2.55M
GTH
46
DELISTED
Genetron Holdings Limited ADS
GTH
$36.6M 0.55%
606,054
– –
CUTR
47
DELISTED
Cutera, Inc.
CUTR
$35.3M 0.53%
+720,817
New +$26.5M
APYX icon
48
Apyx Medical
APYX
$175M
$35M 0.53%
3,391,279
– –
MDXG icon
49
MiMedx Group
MDXG
$609M
$33.8M 0.51%
2,700,320
– –
FULC icon
50
Fulcrum Therapeutics
FULC
$288M
$33.6M 0.51%
3,205,291
– –
1
2
3 4 5

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RTW Investments's Q2 2021 Portfolio in Review

As of Q2 2021, RTW Investments held 125 positions worth $6.63B, up 3.5% from $6.41B the previous quarter. Its ten largest holdings account for 45% of the portfolio.

RTW Investments's Q2 2021 filing shows 14 new, 22 increased, 8 reduced and 12 closed positions. Its largest new stake was GH Research: 2,168,957 shares worth $42.7M. The largest sale was Cerner Corp, an estimated $128M.

By sector, the portfolio is most concentrated in Healthcare at 88% of assets, up from 88% a quarter earlier, followed by Financials.

  • RTW Investments's largest Q2 2021 buy was GH Research: 2,168,957 shares worth $42.7M.
  • RTW Investments added most to ESSA Pharma in Q2 2021, an estimated $80.5M increase.
  • RTW Investments's biggest Q2 2021 reduction was Rocket Pharmaceuticals, cutting an estimated $31.5M.
  • RTW Investments fully exited Cerner Corp in Q2 2021, selling an estimated $128M.
  • RTW Investments's ten largest holdings make up 45% of its $6.63B portfolio in Q2 2021.
  • RTW Investments opened 14 new positions and closed 12 in Q2 2021.
  • RTW Investments's portfolio value rose 3.5% quarter-over-quarter to $6.63B.

Based on RTW Investments's 13F filing for Q2 2021, filed 13 Aug 2021.