PCM
UPB

Prelude Capital Management’s Upstream Bio Inc UPB Stock Holding History

Prelude Capital Management’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$73K Buy
+10,550
New +$88.4K 0.01% 1146
2026
Q1 		– Sell
-16,560
Closed -$450K – 1661
2025
Q4 		$450K Buy
16,560
+825
+5% +$20.5K 0.03% 586
2025
Q3 		$296K Buy
+15,735
New +$244K 0.02% 736

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Prelude Capital Management's UPB Position: Q2 2026 in Review

Prelude Capital Management opened a new position in Upstream Bio Inc (UPB) in Q2 2026: 10,550 shares worth $73K. The stake represents 0.01% of the portfolio and ranks #1146 among its holdings. This is a return to the name: Prelude Capital Management previously reported a position in UPB as recently as Q4 2025.

Prelude Capital Management first reported a position in UPB in Q3 2025 and has held it in 3 quarters since. The position peaked at $450K in Q4 2025. 148 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Prelude Capital Management held 10,550 shares of Upstream Bio Inc worth $73K as of Q2 2026.
  • Upstream Bio Inc was a new Prelude Capital Management position in Q2 2026.
  • Upstream Bio Inc made up 0.01% of Prelude Capital Management's portfolio in Q2 2026, its #1146 holding.
  • Prelude Capital Management first reported a position in Upstream Bio Inc in Q3 2025 and has held it in 3 quarters since.
  • Prelude Capital Management's Upstream Bio Inc position peaked at $450K in Q4 2025.
  • 148 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Prelude Capital Management's 13F filing for Q2 2026, filed 14 Aug 2026.