PAI

Palo Alto Investors Portfolio holdings

AUM $718M
1-Year Est. Return 67.9%
This Fund
S&P 500
This Quarter Est. Return
1 Year Est. Return
+67.9%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$540M
AUM Growth
+$70.4M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
48
New
Increased
Reduced
Closed

Top Buys

1
+$23.8M
2
+$11.4M
3
+$9.89M
4
RARE icon
Ultragenyx Pharmaceutical
RARE
+$9.62M
5
IRON icon
Disc Medicine
IRON
+$4.68M

Top Sells

1
+$45.7M
2
+$17.6M
3
+$13.3M
4
UTHR icon
United Therapeutics
UTHR
+$12.5M
5
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$4.94M

Sector Composition

1 Healthcare 98.77%
2 Financials 1.23%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
TSHA icon
26
Taysha Gene Therapies
TSHA
$1.24B
$4.07M 0.75%
1,246,033
NUVB icon
27
Nuvation Bio
NUVB
$2.03B
$3.78M 0.7%
1,020,547
+247,895
ACRS icon
28
Aclaris Therapeutics
ACRS
$311M
$2.98M 0.55%
1,566,840
+176,812
CRSP icon
29
CRISPR Therapeutics
CRSP
$5.77B
$2.67M 0.49%
41,226
-3,399
TVTX icon
30
Travere Therapeutics
TVTX
$2.67B
$2.65M 0.49%
110,719
EW icon
31
Edwards Lifesciences
EW
$50.2B
$2.62M 0.48%
33,640
-5,833
NBIX icon
32
Neurocrine Biosciences
NBIX
$13.3B
$2.54M 0.47%
18,117
+4,783
STOK icon
33
Stoke Therapeutics
STOK
$2.08B
$2.48M 0.46%
105,427
-20,434
PYXS icon
34
Pyxis Oncology
PYXS
$91.5M
$2.3M 0.43%
1,037,421
BNTX icon
35
BioNTech
BNTX
$27.7B
$1.93M 0.36%
19,614
-5,592
BCYC
36
Bicycle Therapeutics
BCYC
$397M
$1.71M 0.32%
221,071
-27,863
ALDX icon
37
Aldeyra Therapeutics
ALDX
$328M
$1.18M 0.22%
225,465
HUM icon
38
Humana
HUM
$22.9B
$1.04M 0.19%
3,985
ORKA
39
Oruka Therapeutics
ORKA
$1.67B
$791K 0.15%
+59,985
ABEO icon
40
Abeona Therapeutics
ABEO
$277M
$575K 0.11%
108,865
URGN icon
41
UroGen Pharma
URGN
$1.02B
$489K 0.09%
24,500
PRQR icon
42
ProQR Therapeutics
PRQR
$167M
$402K 0.07%
+188,807
AKTX
43
Akari Therapeutics
AKTX
$10.8M
$147K 0.03%
146,024
GBIO
44
DELISTED
Generation Bio
GBIO
$92.1K 0.02%
15,047
-1
KPTI icon
45
Karyopharm Therapeutics
KPTI
$173M
– –
-187,911
STAA icon
46
STAAR Surgical
STAA
$982M
– –
-791,879
ALMS
47
Alumis Inc
ALMS
$3.7B
– –
-143,437
VYNE icon
48
VYNE Therapeutics
VYNE
$20M
– –
-445,434
1
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