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Palo Alto Investors’s Pyxis Oncology PYXS Stock Holding History

Palo Alto Investors’s Portfolio PYXS Stock Details PYXS Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$1.48M Sell
1,010,510
-26,911
-3% -$40.6K 0.23% 40
2025
Q4 		$1.19M Hold
1,037,421
– – 0.17% 40
2025
Q3 		$2.3M Hold
1,037,421
– – 0.43% 34
2025
Q2 		$1.14M Hold
1,037,421
– – 0.24% 36
2025
Q1 		$1.02M Hold
1,037,421
– – 0.19% 36
2024
Q4 		$1.62M Buy
1,037,421
+867,421
+510% +$2.5M 0.25% 30
2024
Q3 		$624K Buy
+170,000
New +$595K 0.08% 41

Other funds holding PYXS

P
Pfizer New York $239M AUM 232.47% 1-Year Est. Return
LCM
Laurion Capital Management New York $2.29B AUM 75.73% 1-Year Est. Return
GGI
GordonMD Global Investments Beverely Hills, California $144M AUM
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
HP
HealthInvest Partners Stockholm, Sweden $372M AUM 59.89% 1-Year Est. Return
6CM
683 Capital Management New York $1.92B AUM 85.52% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
LP
Longaeva Partners Chicago, Illinois $2.7B AUM 37.16% 1-Year Est. Return

Palo Alto Investors's PYXS Position: Q1 2026 in Review

Palo Alto Investors reduced its Pyxis Oncology (PYXS) stake by 2.6% in Q1 2026, selling an estimated $40.6K and leaving 1,010,510 shares worth $1.48M. The position accounts for 0.23% of the portfolio, ranked #40.

Palo Alto Investors first reported a position in PYXS in Q3 2024 and has held it in 7 quarters since. The position peaked at $2.3M in Q3 2025. 78 funds tracked by Wall St. Rank hold PYXS as of Q1 2026.

  • Palo Alto Investors held 1,010,510 shares of Pyxis Oncology worth $1.48M as of Q1 2026.
  • Palo Alto Investors sold 26,911 Pyxis Oncology shares in Q1 2026, an estimated $40.6K.
  • Pyxis Oncology made up 0.23% of Palo Alto Investors's portfolio in Q1 2026, its #40 holding.
  • Palo Alto Investors first reported a position in Pyxis Oncology in Q3 2024 and has held it in 7 quarters since.
  • Palo Alto Investors's Pyxis Oncology position peaked at $2.3M in Q3 2025.
  • 78 funds tracked by Wall St. Rank held Pyxis Oncology as of Q1 2026.

Based on Palo Alto Investors's 13F filing for Q1 2026, filed 15 May 2026.