PAI

Palo Alto Investors Portfolio holdings

AUM $470M
1-Year Return 2.57%
This Quarter Return
+5.27%
1 Year Return
+2.57%
3 Year Return
+93.77%
5 Year Return
+190.64%
10 Year Return
+955.02%
AUM
$470M
AUM Growth
-$55.1M
Cap. Flow
-$44.8M
Cap. Flow %
-9.53%
Top 10 Hldgs %
75.24%
Holding
50
New
6
Increased
5
Reduced
16
Closed
5

Top Buys

1
IRON icon
Disc Medicine
IRON
+$7.72M
2
STAA icon
STAAR Surgical
STAA
+$4.48M
3
RNA icon
Avidity Biosciences
RNA
+$3.38M
4
DNLI icon
Denali Therapeutics
DNLI
+$3.35M
5
CRSP icon
CRISPR Therapeutics
CRSP
+$2.17M

Top Sells

1
SRPT icon
Sarepta Therapeutics
SRPT
+$13.4M
2
INSM icon
Insmed
INSM
+$12.3M
3
FOLD icon
Amicus Therapeutics
FOLD
+$9.94M
4
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$8.29M
5
ANAB icon
AnaptysBio
ANAB
+$4.62M

Sector Composition

1 Healthcare 98.54%
2 Financials 1.46%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
BNTX icon
26
BioNTech
BNTX
$23.3B
$2.68M 0.57%
25,206
– –
DYN icon
27
Dyne Therapeutics
DYN
$1.87B
$2.52M 0.54%
264,976
-68,415
-21% -$651K
CRSP icon
28
CRISPR Therapeutics
CRSP
$5.12B
$2.17M 0.46%
+44,625
New +$2.17M
ACRS icon
29
Aclaris Therapeutics
ACRS
$211M
$1.97M 0.42%
1,390,028
+614,000
+79% +$872K
RARE icon
30
Ultragenyx Pharmaceutical
RARE
$2.92B
$1.77M 0.38%
+48,750
New +$1.77M
BCYC
31
Bicycle Therapeutics
BCYC
$490M
$1.73M 0.37%
248,934
– –
NBIX icon
32
Neurocrine Biosciences
NBIX
$14.1B
$1.68M 0.36%
13,334
– –
TVTX icon
33
Travere Therapeutics
TVTX
$2.09B
$1.64M 0.35%
110,719
– –
NUVB icon
34
Nuvation Bio
NUVB
$1.07B
$1.51M 0.32%
772,652
– –
STOK icon
35
Stoke Therapeutics
STOK
$1.29B
$1.43M 0.3%
125,861
– –
PYXS icon
36
Pyxis Oncology
PYXS
$113M
$1.14M 0.24%
1,037,421
– –
HUM icon
37
Humana
HUM
$33.2B
$974K 0.21%
3,985
– –
ALDX icon
38
Aldeyra Therapeutics
ALDX
$324M
$864K 0.18%
225,465
– –
KPTI icon
39
Karyopharm Therapeutics
KPTI
$55.9M
$810K 0.17%
187,911
-136,121
-42% -$587K
VYNE icon
40
VYNE Therapeutics
VYNE
$7.91M
$735K 0.16%
445,434
– –
ABEO icon
41
Abeona Therapeutics
ABEO
$330M
$618K 0.13%
108,865
– –
ALMS
42
Alumis Inc. Common Stock
ALMS
$455M
$430K 0.09%
+143,437
New +$430K
URGN icon
43
UroGen Pharma
URGN
$869M
$336K 0.07%
24,500
– –
AKTX
44
Akari Therapeutics
AKTX
$25.7M
$171K 0.04%
146,024
– –
GBIO icon
45
Generation Bio
GBIO
$39.9M
$48.2K 0.01%
15,048
– –
RLMD icon
46
Relmada Therapeutics
RLMD
$52.8M
– –
-495,146
Closed -$134K
SLRN
47
DELISTED
ACELYRIN
SLRN
– –
-1,792,895
Closed -$4.43M
SRPT icon
48
Sarepta Therapeutics
SRPT
$1.82B
– –
-210,258
Closed -$13.4M
TIL icon
49
Instil Bio
TIL
$163M
– –
-11,165
Closed -$194K
VERV
50
DELISTED
Verve Therapeutics
VERV
– –
-575,817
Closed -$2.63M
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