PAI

Palo Alto Investors Portfolio holdings

AUM $470M
1-Year Est. Return 2.57%
This Quarter Est. Return
1 Year Est. Return
+2.57%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$525M
AUM Growth
-$120M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
46
New
Increased
Reduced
Closed

Top Buys

1
+$8.1M
2
+$3.49M
3
+$3.35M
4
ANAB icon
AnaptysBio
ANAB
+$3.29M
5
BIIB icon
Biogen
BIIB
+$2.02M

Top Sells

1
+$47M
2
+$15.6M
3
+$15.4M
4
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$5.38M
5
NVRO
NEVRO CORP.
NVRO
+$2.79M

Sector Composition

1 Healthcare 97.86%
2 Financials 2.14%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
BNTX icon
26
BioNTech
BNTX
$24.9B
$2.3M 0.44%
25,206
BCYC
27
Bicycle Therapeutics
BCYC
$428M
$2.11M 0.4%
248,934
TVTX icon
28
Travere Therapeutics
TVTX
$3.02B
$1.98M 0.38%
110,719
TSHA icon
29
Taysha Gene Therapies
TSHA
$1.1B
$1.97M 0.38%
1,419,468
+608,200
NBIX icon
30
Neurocrine Biosciences
NBIX
$15.3B
$1.47M 0.28%
+13,334
NUVB icon
31
Nuvation Bio
NUVB
$1.69B
$1.36M 0.26%
772,652
ALDX icon
32
Aldeyra Therapeutics
ALDX
$296M
$1.3M 0.25%
225,465
KPTI icon
33
Karyopharm Therapeutics
KPTI
$91.4M
$1.21M 0.23%
324,032
-3,101
ACRS icon
34
Aclaris Therapeutics
ACRS
$245M
$1.19M 0.23%
776,028
+206,196
HUM icon
35
Humana
HUM
$31.9B
$1.05M 0.2%
3,985
PYXS icon
36
Pyxis Oncology
PYXS
$243M
$1.02M 0.19%
1,037,421
STOK icon
37
Stoke Therapeutics
STOK
$1.25B
$837K 0.16%
125,861
VYNE icon
38
VYNE Therapeutics
VYNE
$8.61M
$704K 0.13%
445,434
ABEO icon
39
Abeona Therapeutics
ABEO
$224M
$518K 0.1%
108,865
URGN icon
40
UroGen Pharma
URGN
$893M
$271K 0.05%
24,500
TIL icon
41
Instil Bio
TIL
$104M
$194K 0.04%
11,165
AKTX
42
Akari Therapeutics
AKTX
$22.4M
$181K 0.03%
146,024
RLMD icon
43
Relmada Therapeutics
RLMD
$83.3M
$134K 0.03%
495,146
GBIO icon
44
Generation Bio
GBIO
$35M
$60.9K 0.01%
15,048
JSPR icon
45
Jasper Therapeutics
JSPR
$54.5M
– –
-30,651
NVRO
46
DELISTED
NEVRO CORP.
NVRO
– –
-750,371
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