PAI

Palo Alto Investors Portfolio holdings

AUM $470M

1-Year Return 2.57%

2025 Q2 2025 Q1 2024 Q4 2024 Q3 2024 Q2 2024 Q1 2023 Q4 2023 Q3 2023 Q2 2023 Q1 2022 Q4 2022 Q3 2022 Q2 2022 Q1 2021 Q4 2021 Q3 2021 Q2 2021 Q1 2020 Q4 2020 Q3 2020 Q2 2020 Q1 2019 Q4 2019 Q3 2019 Q2 2019 Q1 2018 Q4 2018 Q3 2018 Q2 2018 Q1 2017 Q4 2017 Q3 2017 Q2 2017 Q1 2016 Q4 2016 Q3 2016 Q2 2016 Q1 2015 Q4 2015 Q3 2015 Q2 2015 Q1 2014 Q4 2014 Q3 2014 Q2 2014 Q1 2013 Q4 2013 Q3 2013 Q2

This Quarter Return

+0.2%

1 Year Return

+2.57%

3 Year Return

+93.77%

5 Year Return

+190.64%

10 Year Return

+955.02%

AUM

$645M

AUM Growth

-$124M (-16%)

Cap. Flow

-$61.9M

Cap. Flow % of AUM

-9.6%

Top 10 Holdings % Top 10 Hldgs %

76.62%

Holding

New

Increased

Reduced

Closed

Top Buys

1	NovoCure NVCR	+$6.58M
2	PTC Therapeutics PTCT	+$5.5M
3	Acadia Pharmaceuticals ACAD	+$4.12M
4	BCYC Bicycle Therapeutics BCYC	+$2.65M
5	Pyxis Oncology PYXS	+$1.35M

Top Sells

1	Insmed INSM	+$23.3M
2	STAAR Surgical STAA	+$14.4M
3	United Therapeutics UTHR	+$9.71M
4	RVNC Revance Therapeutics, Inc. RVNC	+$8.37M
5	SAGE Sage Therapeutics SAGE	+$7.3M

Sector Composition

1	Healthcare	97.26%
2	Financials	2.74%

Communication Services

Advertising Agencies

Broadcasting

Electronic Gaming & Multimedia

Entertainment

Internet Content & Information

Publishing

Telecom Services

Consumer Discretionary

Apparel Manufacturing

Apparel Retail

Auto Manufacturers

Auto Parts

Auto & Truck Dealerships

Department Stores

Footwear & Accessories

Furnishings, Fixtures & Appliances

Gambling

Home Improvement Retail

Internet Retail

Leisure

Lodging

Luxury Goods

Packaging & Containers

Personal Services

Recreational Vehicles

Residential Construction

Resorts & Casinos

Restaurants

Specialty Retail

Textile Manufacturing

Travel Services

Consumer Staples

Beverages - Brewers

Beverages - Non-Alcoholic

Beverages - Wineries & Distilleries

Confectioners

Discount Stores

Education & Training Services

Farm Products

Food Distribution

Grocery Stores

Household & Personal Products

Packaged Foods

Tobacco

Energy

Oil & Gas Drilling

Oil & Gas Equipment & Services

Oil & Gas Exploration & Production

Oil & Gas Integrated

Oil & Gas Midstream

Oil & Gas Refining & Marketing

Thermal Coal

Uranium

Financials

Asset Management

Banks - Diversified

Banks - Regional

Capital Markets

Credit Services

Diversified Insurance

Financial Conglomerates

Financial Data & Stock Exchanges

Insurance Brokers

Life Insurance

Mortgage Finance

Property & Casualty Insurance

Reinsurance

Shell Companies

Specialty - Insurance

Healthcare

Biotechnology

Diagnostics & Research

Drug Manufacturers - General

Drug Manufacturers - Specialty & Generic

Healthcare Plans

Health Information Services

Medical Care Facilities

Medical Devices

Medical Distribution

Medical Instruments & Supplies

Pharmaceutical Retailers

Industrials

Aerospace & Defense

Airlines

Airports & Air Services

Building Products & Equipment

Business Equipment & Supplies

Conglomerates

Consulting Services

Electrical Equipment & Parts

Engineering & Construction

Farm & Heavy Construction Machinery

Industrial Distribution

Infrastructure Operations

Integrated Freight & Logistics

Marine Shipping

Metal Fabrication

Pollution & Treatment Controls

Railroads

Rental & Leasing Services

Security & Protection Services

Specialty Business Services

Specialty Industrial Machinery

Staffing & Employment Services

Tools & Accessories

Trucking

Waste Management

Materials

Agricultural Inputs

Aluminum

Building Materials

Chemicals

Coking Coal

Copper

Gold

Lumber & Wood Production

Other Industrial Metals & Mining

Other Precious Metals & Mining

Paper & Paper Products

Silver

Specialty Chemicals

Steel

Real Estate

Diversified REIT

Healthcare Facilities REIT

Hotel & Motel REIT

Industrial REIT

Mortgage REIT

Office REIT

Real Estate Development

Real Estate Diversified

Real Estate Services

Residential REIT

Retail REIT

Specialty REIT

Technology

Communication Equipment

Computer Hardware

Consumer Electronics

Electronic Components

Electronics & Computer Distribution

Information Technology Services

Scientific & Technical Instruments

Semiconductor Equipment & Materials

Semiconductors

Software - Application

Software - Infrastructure

Solar

Utilities

Diversified Utilities

Electric Utilities

Gas Utilities

Independent Power Producers

Renewable Electricity

Water Utilities

#	Name	Market Value	Portfolio Weight	Shares or Principal	Shares Change %	Capital Flow
26	NVRO 26 DELISTED NEVRO CORP. NVRO	$2.79M	0.43%	750,371	–	–
27	27 Mirum Pharmaceuticals MIRM $3.73B	$2.68M	0.41%	64,700	–	–
28	28 Nuvation Bio NUVB $1.07B	$2.06M	0.32%	772,652	–	–
29	29 Travere Therapeutics TVTX $2.09B	$1.93M	0.3%	110,719	–	–
30	30 Pyxis Oncology PYXS $113M	$1.62M	0.25%	1,037,421 +867,421	+510%	+$1.35M
31	31 VYNE Therapeutics VYNE $7.91M	$1.49M	0.23%	445,434	–	–
32	32 Aclaris Therapeutics ACRS $211M	$1.41M	0.22%	569,832	–	–
33	33 Taysha Gene Therapies TSHA $837M	$1.4M	0.22%	811,268	–	–
34	34 Stoke Therapeutics STOK $1.29B	$1.39M	0.22%	125,861	–	–
35	35 Aldeyra Therapeutics ALDX $324M	$1.13M	0.17%	225,465	–	–
36	36 Humana HUM $33.2B	$1.01M	0.16%	3,985	–	–
37	37 Jasper Therapeutics JSPR $39.5M	$655K	0.1%	+30,651	New	+$655K
38	38 Abeona Therapeutics ABEO $330M	$606K	0.09%	108,865 +96,000	+746%	+$535K
39	39 UroGen Pharma URGN $869M	$261K	0.04%	24,500	–	–
40	40 Relmada Therapeutics RLMD $52.8M	$257K	0.04%	495,146 -237,254	-32%	-$123K
41	41 Instil Bio TIL $163M	$213K	0.03%	11,165	–	–
42	AKTX 42 Akari Therapeutics AKTX $25.7M	$178K	0.03%	+146,024	New	+$178K
43	43 Generation Bio GBIO $39.9M	$160K	0.02%	15,048	–	–
44	BLUE 44 DELISTED bluebird bio BLUE	–	–	-30,213	Closed	-$314K
45	ELEV 45 DELISTED Elevation Oncology ELEV	–	–	-1,298,097	Closed	-$779K
46	SAGE 46 DELISTED Sage Therapeutics SAGE	–	–	-1,010,833	Closed	-$7.3M
47	RVNC 47 DELISTED Revance Therapeutics, Inc. RVNC	–	–	-1,611,787	Closed	-$8.37M