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NLVP

New Leaf Venture Partners Portfolio holdings

AUM $43M Turnover 12.5%
1-Year Est. Return 25.55%
This Fund
S&P 500
This Quarter Est. Return
+33.07%
1 Year Est. Return
-25.55%
3 Year Est. Return
+17.13%
5 Year Est. Return
+114.46%
10 Year Est. Return
+1,011.57%
AUM
$43M
AUM Growth
-$9.9M
Cap. Flow
-$604K
Cap. Flow %
-1.4%
Top 10 Hldgs %
100%
Holding
8
New
–
Increased
–
Reduced
1
Closed
1
Avg Time Held
6 years
Top 10 Avg Time Held
3.9 years
Top 20 Avg Time Held
6 years

Top Buys

No buys this quarter

Top Sells

Rank Stock Value
1
ITRM icon
Iterum Therapeutics
ITRM
+$343K
2
PASG icon
Passage Bio
PASG
+$261K

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow Held Since
EWTX icon
1
Edgewise Therapeutics
EWTX
$4.12B
$16.7M 38.82%
1,030,161
– –
2021 Q1
18 quarters
ARVN icon
2
Arvinas
ARVN
$475M
$13.5M 31.38%
1,585,721
– –
2018 Q3
28 quarters
CRNX icon
3
DELISTED
Crinetics Pharmaceuticals
CRNX
$5.87M 13.64%
141,000
– –
2018 Q3
28 quarters
COGT icon
4
Cogent Biosciences
COGT
$5.21B
$3.6M 8.37%
250,765
– –
2018 Q1
30 quarters
RLYB icon
5
Rallybio
RLYB
$86.9M
$1.65M 3.83%
412,700
– –
2021 Q3
16 quarters
ALEC icon
6
Alector
ALEC
$218M
$1.01M 2.33%
339,569
– –
2019 Q1
26 quarters
PASG icon
7
Passage Bio
PASG
$11.5M
$702K 1.63%
87,426
-37,470
-30% -$261K
2020 Q1
22 quarters
ITRM icon
8
DELISTED
Iterum Therapeutics
ITRM
– –
-345,020
Closed -$343K –

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New Leaf Venture Partners's Q3 2025 Portfolio in Review

As of Q3 2025, New Leaf Venture Partners held 8 positions worth $43M, down 19% from $52.9M the previous quarter. Its ten largest holdings account for 100% of the portfolio.

New Leaf Venture Partners's Q3 2025 filing shows 1 reduced and 1 closed positions. The largest sale was Iterum Therapeutics, an estimated $343K.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, unchanged from a quarter earlier.

  • New Leaf Venture Partners's biggest Q3 2025 reduction was Passage Bio, cutting an estimated $261K.
  • New Leaf Venture Partners fully exited Iterum Therapeutics in Q3 2025, selling an estimated $343K.
  • New Leaf Venture Partners's ten largest holdings make up 100% of its $43M portfolio in Q3 2025.
  • New Leaf Venture Partners opened 0 new positions and closed 1 in Q3 2025.
  • New Leaf Venture Partners's portfolio value fell 19% quarter-over-quarter to $43M.

Based on New Leaf Venture Partners's 13F filing for Q3 2025, filed 14 Nov 2025.