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NLVP

New Leaf Venture Partners Portfolio holdings

AUM $43M
1-Year Est. Return 25.55%
This Fund
S&P 500
This Quarter Est. Return
-11.65%
1 Year Est. Return
-25.55%
3 Year Est. Return
+17.13%
5 Year Est. Return
+114.46%
10 Year Est. Return
+1,011.57%
AUM
$74.8M
AUM Growth
-$22.5M
Cap. Flow
-$13.2M
Cap. Flow %
-17.68%
Top 10 Hldgs %
100%
Holding
10
New
–
Increased
1
Reduced
1
Closed
1

Top Buys

Rank Stock Value
1
ARVN icon
Arvinas
ARVN
+$3.67M

Top Sells

Rank Stock Value
1
EWTX icon
Edgewise Therapeutics
EWTX
+$16.7M
2
XFOR icon
X4 Pharmaceuticals
XFOR
+$224K

Sector Composition

Rank Sector Weight
1 Healthcare 100%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ARVN icon
1
Arvinas
ARVN
$518M
$30.4M 40.64%
1,585,721
+151,000
+11% +$3.67M
EWTX icon
2
Edgewise Therapeutics
EWTX
$4.39B
$27.5M 36.77%
1,030,161
-523,500
-34% -$16.7M
CRNX icon
3
Crinetics Pharmaceuticals
CRNX
$8.86B
$7.21M 9.64%
141,000
– –
RLYB icon
4
Rallybio
RLYB
$86.6M
$3.17M 4.24%
412,700
– –
COGT icon
5
Cogent Biosciences
COGT
$6.79B
$1.96M 2.61%
250,765
– –
RCKT icon
6
Rocket Pharmaceuticals
RCKT
$348M
$1.89M 2.53%
150,706
– –
PASG icon
7
Passage Bio
PASG
$15.9M
$1.42M 1.89%
124,896
– –
ALEC icon
8
Alector
ALEC
$164M
$642K 0.86%
339,569
– –
ITRM
9
DELISTED
Iterum Therapeutics
ITRM
$611K 0.82%
345,020
– –
XFOR icon
10
X4 Pharmaceuticals
XFOR
$363M
– –
-11,167
Closed -$224K

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New Leaf Venture Partners's Q4 2024 Portfolio in Review

As of Q4 2024, New Leaf Venture Partners held 10 positions worth $74.8M, down 23% from $97.3M the previous quarter. Its ten largest holdings account for 100% of the portfolio.

New Leaf Venture Partners withdrew a net $13.2M in Q4 2024, closing 1 position and reducing 1 holding. Its most notable exit was X4 Pharmaceuticals, an estimated $224K position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, unchanged from a quarter earlier.

Against the trend, New Leaf Venture Partners added an estimated $3.67M to Arvinas.

  • New Leaf Venture Partners added most to Arvinas in Q4 2024, an estimated $3.67M increase.
  • New Leaf Venture Partners's biggest Q4 2024 reduction was Edgewise Therapeutics, cutting an estimated $16.7M.
  • New Leaf Venture Partners fully exited X4 Pharmaceuticals in Q4 2024, selling an estimated $224K.
  • New Leaf Venture Partners's ten largest holdings make up 100% of its $74.8M portfolio in Q4 2024.
  • New Leaf Venture Partners opened 0 new positions and closed 1 in Q4 2024.
  • New Leaf Venture Partners's portfolio value fell 23% quarter-over-quarter to $74.8M.

Based on New Leaf Venture Partners's 13F filing for Q4 2024, filed 13 Feb 2025.