Manulife (Manufacturers Life Insurance)
UPB

Manulife (Manufacturers Life Insurance)’s Upstream Bio Inc UPB Stock Holding History

Manulife (Manufacturers Life Insurance)’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$138K Buy
15,338
+5,191
+51% +$93.4K ﹤0.01% 2555
2025
Q4 		$275K Sell
10,147
-1,945
-16% -$48.4K ﹤0.01% 2392
2025
Q3 		$227K Sell
12,092
-1,098
-8% -$17.1K ﹤0.01% 2509
2025
Q2 		$145K Buy
+13,190
New +$122K ﹤0.01% 2667

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Manulife (Manufacturers Life Insurance)'s UPB Position: Q1 2026 in Review

Manulife (Manufacturers Life Insurance) increased its Upstream Bio Inc (UPB) stake by 51% in Q1 2026, buying an estimated $93.4K and bringing the position to 15,338 shares worth $138K. The position accounts for ﹤0.01% of the portfolio, ranked #2555.

Manulife (Manufacturers Life Insurance) first reported a position in UPB in Q2 2025 and has held it in 4 quarters since. The position peaked at $275K in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • Manulife (Manufacturers Life Insurance) held 15,338 shares of Upstream Bio Inc worth $138K as of Q1 2026.
  • Manulife (Manufacturers Life Insurance) bought 5,191 Upstream Bio Inc shares in Q1 2026, an estimated $93.4K.
  • Upstream Bio Inc made up ﹤0.01% of Manulife (Manufacturers Life Insurance)'s portfolio in Q1 2026, its #2555 holding.
  • Manulife (Manufacturers Life Insurance) first reported a position in Upstream Bio Inc in Q2 2025 and has held it in 4 quarters since.
  • Manulife (Manufacturers Life Insurance)'s Upstream Bio Inc position peaked at $275K in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Manulife (Manufacturers Life Insurance)'s 13F filing for Q1 2026, filed 15 May 2026.