Jane Street’s Structure Therapeutics GPCR Stock Holding History

Jane Street’s Portfolio GPCR Stock Details GPCR Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$3.07M	Buy	63,600 +19,600	+45%	+$1.34M	﹤0.01%	4303
2025 Q4	$3.06M	Buy	44,000 +11,800	+37%	+$482K	﹤0.01%	4008
2025 Q3	$902K	Sell	32,200 -12,000	-27%	-$239K	﹤0.01%	6538
2025 Q2	$917K	Buy	44,200 +5,000	+13%	+$110K	﹤0.01%	5780
2025 Q1	$679K	Buy	39,200 +19,300	+97%	+$473K	﹤0.01%	6302
2024 Q4	$540K	Sell	19,900 -15,700	-44%	-$557K	﹤0.01%	6627
2024 Q3	$1.56M	Sell	35,600 -156,400	-81%	-$6.05M	﹤0.01%	4976
2024 Q2	$7.54M	Buy	192,000 +21,100	+12%	+$866K	﹤0.01%	2378
2024 Q1	$7.32M	Buy	170,900 +125,700	+278%	+$5.3M	﹤0.01%	2142
2023 Q4	$1.84M	Buy	+45,200	New	+$2.59M	﹤0.01%	4473

Other funds holding GPCR

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return

DTC

Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return

Principal Financial Group Des Moines, Iowa $187B AUM 18.48% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return

Jane Street's GPCR Position: Q1 2026 in Review

Jane Street sold out of Structure Therapeutics (GPCR) in Q1 2026, closing a stake of 147,217 shares — an estimated $10.1M sold.

Jane Street first reported a position in GPCR in Q4 2023 and held it in 7 quarters. The position peaked at $10.2M in Q4 2025. 196 funds tracked by Wall St. Rank hold GPCR as of Q1 2026.

Jane Street reported no remaining Structure Therapeutics position as of Q1 2026 after selling out during the quarter.
Jane Street sold 147,217 Structure Therapeutics shares in Q1 2026, an estimated $10.1M.
Jane Street first reported a position in Structure Therapeutics in Q4 2023 and held it in 7 quarters.
Jane Street's Structure Therapeutics position peaked at $10.2M in Q4 2025.
196 funds tracked by Wall St. Rank held Structure Therapeutics as of Q1 2026.

Based on Jane Street's 13F filing for Q1 2026, filed 12 May 2026.