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EcoR1 Capital Portfolio holdings

AUM $2.06B Turnover 46.34%
1-Year Est. Return 215.32%
This Fund
S&P 500
This Quarter Est. Return
+20.21%
1 Year Est. Return
+215.32%
3 Year Est. Return
+310.3%
5 Year Est. Return
+497.45%
10 Year Est. Return
+14,692.23%
AUM
$2.06B
AUM Growth
-$300M
Cap. Flow
-$581M
Cap. Flow %
-28.26%
Top 10 Hldgs %
86.31%
Holding
41
New
11
Increased
3
Reduced
4
Closed
8
Avg Time Held Equity + Options
1.2 years
Top 10 Avg Time Held Equity + Options
1.1 years
Top 20 Avg Time Held Equity + Options
1 year
Avg Time Held Equity only
1.3 years
Top 10 Avg Time Held Equity only
1.1 years
Top 20 Avg Time Held Equity only
1 year

Top Buys

Rank Stock Value
1
TRAX icon
First Tracks Biotherapeutics
TRAX
+$59.3M
2
FULC icon
Fulcrum Therapeutics
FULC
+$39.8M
3
CGON icon
CG Oncology
CGON
+$25.6M
4
LEGN icon
Legend Biotech
LEGN
+$21.6M
5
STOK icon
Stoke Therapeutics
STOK
+$20.4M

Top Sells

Rank Stock Value
1
JAZZ icon
Jazz Pharmaceuticals
JAZZ
+$323M
2
CNTA
Centessa Pharmaceuticals
CNTA
+$238M
3
CRNX icon
Crinetics Pharmaceuticals
CRNX
+$156M
4
XNCR icon
Xencor
XNCR
+$26.3M
5
RLAY icon
Relay Therapeutics
RLAY
+$17.5M

Sector Composition

Rank Sector Weight
1 Healthcare 97.95%
2 Miscellaneous 1.95%
3 Financials 0.1%

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EcoR1 Capital's Q2 2026 Portfolio in Review

As of Q2 2026, EcoR1 Capital held 41 positions worth $2.06B, down 13% from $2.36B the previous quarter. Its ten largest holdings account for 86% of the portfolio.

EcoR1 Capital withdrew a net $581M in Q2 2026, closing 8 positions and reducing 4 holdings. Its most notable exit was Jazz Pharmaceuticals, an estimated $323M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 99% a quarter earlier, followed by Miscellaneous and Financials.

Against the trend, EcoR1 Capital opened a new position in First Tracks Biotherapeutics worth $63.9M.

  • EcoR1 Capital's largest Q2 2026 buy was First Tracks Biotherapeutics: 3,174,519 shares worth $63.9M.
  • EcoR1 Capital added most to CG Oncology in Q2 2026, an estimated $25.6M increase.
  • EcoR1 Capital's biggest Q2 2026 reduction was Relay Therapeutics, cutting an estimated $17.5M.
  • EcoR1 Capital fully exited Jazz Pharmaceuticals in Q2 2026, selling an estimated $323M.
  • EcoR1 Capital's ten largest holdings make up 86% of its $2.06B portfolio in Q2 2026.
  • EcoR1 Capital opened 11 new positions and closed 8 in Q2 2026.
  • EcoR1 Capital's portfolio value fell 13% quarter-over-quarter to $2.06B.

Based on EcoR1 Capital's 13F filing for Q2 2026, filed 14 Aug 2026.