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David Shaw’s Tyra Biosciences TYRA Stock Holding History

David Shaw’s Portfolio TYRA Stock Details TYRA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$645K Buy
+20,189
New +$668K ﹤0.01% 4041
2024
Q4 		– Sell
-32,003
Closed -$752K – 4892
2024
Q3 		$752K Buy
+32,003
New +$672K ﹤0.01% 3466
2023
Q1 		– Sell
-33,005
Closed -$251K – 4875
2022
Q4 		$251K Sell
33,005
-1,881
-5% -$13.3K ﹤0.01% 4156
2022
Q3 		$307K Sell
34,886
-21,168
-38% -$194K ﹤0.01% 4286
2022
Q2 		$401K Sell
56,054
-27,384
-33% -$218K ﹤0.01% 4224
2022
Q1 		$893K Sell
83,438
-44,425
-35% -$527K ﹤0.01% 4007
2021
Q4 		$1.8M Buy
+127,863
New +$2.54M ﹤0.01% 3448

Other funds holding TYRA

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM
APMC
Alta Partners Management Company Jackson, Wyoming $127M AUM 230.85% 1-Year Est. Return
NI
Nextech Invest Zurich, Switzerland $2.11B AUM 413.84% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $4.16B AUM 983.43% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
CC
Commodore Capital New York $1.68B AUM 375.52% 1-Year Est. Return

David Shaw's TYRA Position: Q2 2026 in Review

David Shaw opened a new position in Tyra Biosciences (TYRA) in Q2 2026: 20,189 shares worth $645K. The stake represents ﹤0.01% of the portfolio and ranks #4041 among its holdings. This is a return to the name: David Shaw previously reported a position in TYRA as recently as Q3 2024.

David Shaw first reported a position in TYRA in Q4 2021 and has held it in 7 quarters since. The position peaked at $1.8M in Q4 2021. 169 funds tracked by Wall St. Rank hold TYRA as of Q2 2026.

  • David Shaw held 20,189 shares of Tyra Biosciences worth $645K as of Q2 2026.
  • Tyra Biosciences was a new David Shaw position in Q2 2026.
  • Tyra Biosciences made up ﹤0.01% of David Shaw's portfolio in Q2 2026, its #4041 holding.
  • David Shaw first reported a position in Tyra Biosciences in Q4 2021 and has held it in 7 quarters since.
  • David Shaw's Tyra Biosciences position peaked at $1.8M in Q4 2021.
  • 169 funds tracked by Wall St. Rank held Tyra Biosciences as of Q2 2026.

Based on D.E. Shaw & Co's 13F filing for Q2 2026, filed 14 Aug 2026.