5AM Venture Management’s Tyra Biosciences TYRA Stock Holding History

5AM Venture Management’s Portfolio TYRA Stock Details TYRA Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$32.9M	Hold	1,029,298	–	–	11.42%	2
2026 Q1	$39.4M	Hold	1,029,298	–	–	10.94%	3
2025 Q4	$27.1M	Buy	1,029,298 +90,000	+10%	+$1.65M	8.51%	3
2025 Q3	$13.1M	Hold	939,298	–	–	4.81%	10
2025 Q2	$8.99M	Hold	939,298	–	–	3.46%	13
2025 Q1	$8.74M	Hold	939,298	–	–	3.3%	13
2024 Q4	$13.1M	Hold	939,298	–	–	3.12%	15
2024 Q3	$22.1M	Hold	939,298	–	–	4.56%	7
2024 Q2	$15M	Hold	939,298	–	–	3.36%	7
2024 Q1	$15.4M	Buy	939,298 +384,319	+69%	+$6.3M	3.45%	11
2023 Q4	$7.69M	Buy	554,979 +143,529	+35%	+$1.86M	2.04%	15
2023 Q3	$5.67M	Buy	+411,450	New	+$6.1M	1.63%	19

Other funds holding TYRA

RCM

RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

Jupiter Topco New York $245B AUM

APMC

Alta Partners Management Company Jackson, Wyoming $127M AUM 230.85% 1-Year Est. Return

Nextech Invest Zurich, Switzerland $2.11B AUM 413.84% 1-Year Est. Return

TCM

TCG Crossover Management Palo Alto, California $4.16B AUM 983.43% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return

State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

Commodore Capital New York $1.68B AUM 375.52% 1-Year Est. Return

5AM Venture Management's TYRA Position: Q2 2026 in Review

5AM Venture Management held its Tyra Biosciences (TYRA) position steady in Q2 2026 at 1,029,298 shares worth $32.9M. The position accounts for 11.42% of the portfolio, ranked #2.

5AM Venture Management first reported a position in TYRA in Q3 2023 and has held it in 12 quarters since. The position peaked at $39.4M in Q1 2026. 170 funds tracked by Wall St. Rank hold TYRA as of Q2 2026.

5AM Venture Management held 1,029,298 shares of Tyra Biosciences worth $32.9M as of Q2 2026.
5AM Venture Management left its Tyra Biosciences share count unchanged in Q2 2026.
Tyra Biosciences made up 11.42% of 5AM Venture Management's portfolio in Q2 2026, its #2 holding.
5AM Venture Management first reported a position in Tyra Biosciences in Q3 2023 and has held it in 12 quarters since.
5AM Venture Management's Tyra Biosciences position peaked at $39.4M in Q1 2026.
170 funds tracked by Wall St. Rank held Tyra Biosciences as of Q2 2026.

Based on 5AM Venture Management's 13F filing for Q2 2026, filed 14 Aug 2026.