|
1
|
Franklin Resources
San Mateo,
California
|
101 Mio. $
|
-788.903 $
|
-50.280
|
-0,6 %
|
|
|
2
|
Tang Capital Management
San Diego,
California
|
81,2 Mio. $
|
–
|
–
|
–
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
76,9 Mio. $
|
+322.355 $
|
+20.545
|
+0,4 %
|
|
|
4
|
Janus Henderson Investors US
Denver,
Colorado
|
59,9 Mio. $
|
+8,5 Mio. $
|
+542.007
|
+13 %
|
|
|
5
|
Broadfin Capital
New York
|
51,1 Mio. $
|
+16,5 Mio. $
|
+1.049.587
|
+37 %
|
|
|
6
|
Kingdon Capital Management
New York
|
36,9 Mio. $
|
+1,84 Mio. $
|
+117.164
|
+4 %
|
|
|
7
|
PFM Health Sciences
San Francisco,
California
|
35,8 Mio. $
|
-10,3 Mio. $
|
-656.975
|
-19 %
|
|
|
8
|
Baker Bros. Advisors
New York
|
31,2 Mio. $
|
-7,43 Mio. $
|
-473.681
|
-17 %
|
|
|
9
|
Cormorant Asset Management
Boston,
Massachusetts
|
25,6 Mio. $
|
+2,82 Mio. $
|
+180.000
|
+10 %
|
|
|
10
|
Highland Capital Management (Texas)
Dallas,
Texas
|
20,5 Mio. $
|
+14,3 Mio. $
|
+912.086
|
+140 %
|
|
|
11
|
State Street
Boston,
Massachusetts
|
17,9 Mio. $
|
+4,24 Mio. $
|
+270.022
|
+25 %
|
|
|
12
|
Vanguard Group
Malvern,
Pennsylvania
|
17,5 Mio. $
|
+416.732 $
|
+26.560
|
+2 %
|
|
|
13
|
|
14,4 Mio. $
|
–
|
–
|
–
|
|
|
14
|
BlackRock Fund Advisors
San Francisco,
California
|
13,4 Mio. $
|
+2,22 Mio. $
|
+141.735
|
+16 %
|
|
|
15
|
BlackRock Institutional Trust
San Francisco,
California
|
10,9 Mio. $
|
+11.736 $
|
+748
|
+0,1 %
|
|
|
16
|
|
7,67 Mio. $
|
-34,3 Mio. $
|
-2.187.837
|
-79 %
|
|
|
17
|
Rubric Capital Management (New York)
New York
|
7,2 Mio. $
|
+8,63 Mio. $
|
+550.000
|
Neu
|
|
|
18
|
Alyeska Investment Group
Chicago,
Illinois
|
6,86 Mio. $
|
+5,13 Mio. $
|
+327.255
|
+167 %
|
|
|
19
|
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
6,37 Mio. $
|
+5,04 Mio. $
|
+321.445
|
+195 %
|
|
|
20
|
Royal Bank of Canada
Toronto,
Ontario, Canada
|
5,4 Mio. $
|
-85.339 $
|
-5.439
|
-1 %
|
|
|
21
|
VHCP Management II
New York
|
5,32 Mio. $
|
–
|
–
|
–
|
|
|
22
|
Northern Trust
Chicago,
Illinois
|
4,8 Mio. $
|
+132.111 $
|
+8.420
|
+2 %
|
|
|
23
|
Panagora Asset Management
Boston,
Massachusetts
|
3,59 Mio. $
|
+1,13 Mio. $
|
+72.316
|
+36 %
|
|
|
24
|
Geode Capital Management
Boston,
Massachusetts
|
3,46 Mio. $
|
+149.339 $
|
+9.518
|
+4 %
|
|
|
25
|
Millennium Management
New York
|
3,37 Mio. $
|
+4,03 Mio. $
|
+257.062
|
Neu
|
|
