|
1
|
Franklin Resources
San Mateo,
California
|
133 Mio. $
|
-308.217 $
|
-16.612
|
-0,2 %
|
|
|
2
|
Tang Capital Management
San Diego,
California
|
107 Mio. $
|
–
|
–
|
–
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
101 Mio. $
|
+6,66 Mio. $
|
+358.874
|
+7 %
|
|
|
4
|
Janus Henderson Investors US
Denver,
Colorado
|
69,5 Mio. $
|
+368.833 $
|
+19.879
|
+0,5 %
|
|
|
5
|
PFM Health Sciences
San Francisco,
California
|
58,4 Mio. $
|
+726.348 $
|
+39.148
|
+1 %
|
|
|
6
|
Baker Bros. Advisors
New York
|
49,2 Mio. $
|
–
|
–
|
–
|
|
|
7
|
Broadfin Capital
New York
|
49,1 Mio. $
|
+29,7 Mio. $
|
+1.599.896
|
+128 %
|
|
|
8
|
|
47,8 Mio. $
|
-2,52 Mio. $
|
-135.935
|
-5 %
|
|
|
9
|
Kingdon Capital Management
New York
|
46,5 Mio. $
|
+33,1 Mio. $
|
+1.784.890
|
+196 %
|
|
|
10
|
Cormorant Asset Management
Boston,
Massachusetts
|
30,5 Mio. $
|
–
|
–
|
–
|
|
|
11
|
Vanguard Group
Malvern,
Pennsylvania
|
22,6 Mio. $
|
+1,77 Mio. $
|
+95.637
|
+8 %
|
|
|
12
|
State Street
Boston,
Massachusetts
|
18,9 Mio. $
|
+1,92 Mio. $
|
+103.311
|
+10 %
|
|
|
13
|
|
18,9 Mio. $
|
–
|
–
|
–
|
|
|
14
|
BlackRock Fund Advisors
San Francisco,
California
|
15,1 Mio. $
|
+943.930 $
|
+50.875
|
+6 %
|
|
|
15
|
BlackRock Institutional Trust
San Francisco,
California
|
14,3 Mio. $
|
+1,47 Mio. $
|
+79.227
|
+11 %
|
|
|
16
|
Highland Capital Management (Texas)
Dallas,
Texas
|
11,2 Mio. $
|
+12,1 Mio. $
|
+650.731
|
Neu
|
|
|
17
|
Royal Bank of Canada
Toronto,
Ontario, Canada
|
7,2 Mio. $
|
+7,75 Mio. $
|
+417.900
|
Neu
|
|
|
18
|
VHCP Management II
New York
|
6,99 Mio. $
|
–
|
–
|
–
|
|
|
19
|
|
6,66 Mio. $
|
+7,18 Mio. $
|
+386.787
|
Neu
|
|
|
20
|
Northern Trust
Chicago,
Illinois
|
6,17 Mio. $
|
+23.860 $
|
+1.286
|
+0,4 %
|
|
|
21
|
Asset Management One
Tokyo,
Japan
|
4,69 Mio. $
|
-481.826 $
|
-25.969
|
-9 %
|
|
|
22
|
Geode Capital Management
Boston,
Massachusetts
|
4,39 Mio. $
|
+668.868 $
|
+36.050
|
+16 %
|
|
|
23
|
Panagora Asset Management
Boston,
Massachusetts
|
3,48 Mio. $
|
-1,11 Mio. $
|
-59.641
|
-23 %
|
|
|
24
|
Boxer Capital
San Diego,
California
|
3,45 Mio. $
|
+3,71 Mio. $
|
+200.000
|
Neu
|
|
|
25
|
Alyeska Investment Group
Chicago,
Illinois
|
3,38 Mio. $
|
+3,64 Mio. $
|
+196.342
|
Neu
|
|
