|
1
|
Franklin Resources
San Mateo,
California
|
143 Mio. $
|
+32,6 Mio. $
|
+1.653.008
|
+28 %
|
|
|
2
|
Fidelity Investments
Boston,
Massachusetts
|
103 Mio. $
|
+772.516 $
|
+39.154
|
+0,7 %
|
|
|
3
|
Tang Capital Management
San Diego,
California
|
98,6 Mio. $
|
–
|
–
|
–
|
|
|
4
|
Janus Henderson Investors US
Denver,
Colorado
|
66,4 Mio. $
|
+7,23 Mio. $
|
+366.408
|
+12 %
|
|
|
5
|
|
59,7 Mio. $
|
-3,28 Mio. $
|
-166.177
|
-5 %
|
|
|
6
|
PFM Health Sciences
San Francisco,
California
|
58,4 Mio. $
|
+5,84 Mio. $
|
+296.006
|
+11 %
|
|
|
7
|
Baker Bros. Advisors
New York
|
55,2 Mio. $
|
–
|
–
|
–
|
|
|
8
|
Cormorant Asset Management
Boston,
Massachusetts
|
33,2 Mio. $
|
+1,27 Mio. $
|
+64.281
|
+4 %
|
|
|
9
|
Broadfin Capital
New York
|
27,8 Mio. $
|
-15,1 Mio. $
|
-766.526
|
-34 %
|
|
|
10
|
State Street
Boston,
Massachusetts
|
22,9 Mio. $
|
-4,26 Mio. $
|
-215.739
|
-15 %
|
|
|
11
|
Vanguard Group
Malvern,
Pennsylvania
|
22 Mio. $
|
+1,08 Mio. $
|
+54.940
|
+5 %
|
|
|
12
|
|
20,8 Mio. $
|
–
|
–
|
–
|
|
|
13
|
BlackRock Fund Advisors
San Francisco,
California
|
14,4 Mio. $
|
-712.280 $
|
-36.101
|
-5 %
|
|
|
14
|
BlackRock Institutional Trust
San Francisco,
California
|
13,6 Mio. $
|
+196.888 $
|
+9.979
|
+1 %
|
|
|
15
|
Allianz Asset Management
Munich,
Germany
|
8,98 Mio. $
|
+508.783 $
|
+25.787
|
+6 %
|
|
|
16
|
Kingdon Capital Management
New York
|
8,22 Mio. $
|
-8,6 Mio. $
|
-435.945
|
-50 %
|
|
|
17
|
VHCP Management II
New York
|
7,71 Mio. $
|
+8,01 Mio. $
|
+405.901
|
Neu
|
|
|
18
|
|
6,62 Mio. $
|
+389.415 $
|
+19.737
|
+6 %
|
|
|
19
|
Northern Trust
Chicago,
Illinois
|
6,49 Mio. $
|
-16.416 $
|
-832
|
-0,2 %
|
|
|
20
|
Brown Advisory
Baltimore,
Maryland
|
5,63 Mio. $
|
-90.463 $
|
-4.585
|
-2 %
|
|
|
21
|
Asset Management One
Tokyo,
Japan
|
5,4 Mio. $
|
+568.210 $
|
+28.799
|
+12 %
|
|
|
22
|
Panagora Asset Management
Boston,
Massachusetts
|
4,66 Mio. $
|
+2,3 Mio. $
|
+116.461
|
+90 %
|
|
|
23
|
Tekla Capital Management
Boston,
Massachusetts
|
4,16 Mio. $
|
–
|
–
|
–
|
|
|
24
|
Geode Capital Management
Boston,
Massachusetts
|
3,94 Mio. $
|
+57.375 $
|
+2.908
|
+1 %
|
|
|
25
|
Fred Alger Management
New York
|
3,25 Mio. $
|
-1,45 Mio. $
|
-73.407
|
-30 %
|
|
