|
1
|
Franklin Resources
San Mateo,
California
|
140 Mio. $
|
+4,47 Mio. $
|
+229.182
|
+3 %
|
|
|
2
|
Tang Capital Management
San Diego,
California
|
112 Mio. $
|
+19,6 Mio. $
|
+1.006.361
|
+19 %
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
99,2 Mio. $
|
+1,25 Mio. $
|
+63.968
|
+1 %
|
|
|
4
|
Janus Henderson Investors US
Denver,
Colorado
|
72,4 Mio. $
|
+10,1 Mio. $
|
+516.166
|
+15 %
|
|
|
5
|
PFM Health Sciences
San Francisco,
California
|
60,5 Mio. $
|
+5,42 Mio. $
|
+277.634
|
+9 %
|
|
|
6
|
|
52,5 Mio. $
|
-4,62 Mio. $
|
-236.617
|
-8 %
|
|
|
7
|
Baker Bros. Advisors
New York
|
51,6 Mio. $
|
-986.540 $
|
-50.534
|
-2 %
|
|
|
8
|
Cormorant Asset Management
Boston,
Massachusetts
|
32 Mio. $
|
+415.103 $
|
+21.263
|
+1 %
|
|
|
9
|
Broadfin Capital
New York
|
22,6 Mio. $
|
-4,2 Mio. $
|
-215.371
|
-15 %
|
|
|
10
|
Vanguard Group
Malvern,
Pennsylvania
|
21,9 Mio. $
|
+1,13 Mio. $
|
+58.039
|
+5 %
|
|
|
11
|
|
19,8 Mio. $
|
–
|
–
|
–
|
|
|
12
|
State Street
Boston,
Massachusetts
|
17,9 Mio. $
|
-4,18 Mio. $
|
-214.340
|
-18 %
|
|
|
13
|
Kingdon Capital Management
New York
|
16,4 Mio. $
|
+9,33 Mio. $
|
+478.023
|
+110 %
|
|
|
14
|
BlackRock Fund Advisors
San Francisco,
California
|
14,9 Mio. $
|
+1,37 Mio. $
|
+70.177
|
+9 %
|
|
|
15
|
BlackRock Institutional Trust
San Francisco,
California
|
13,6 Mio. $
|
+724.434 $
|
+37.108
|
+5 %
|
|
|
16
|
Tekla Capital Management
Boston,
Massachusetts
|
8,89 Mio. $
|
+5,34 Mio. $
|
+273.303
|
+125 %
|
|
|
17
|
VHCP Management II
New York
|
7,33 Mio. $
|
–
|
–
|
–
|
|
|
18
|
Northern Trust
Chicago,
Illinois
|
6,44 Mio. $
|
+300.546 $
|
+15.395
|
+5 %
|
|
|
19
|
|
6,08 Mio. $
|
-230.305 $
|
-11.797
|
-3 %
|
|
|
20
|
Brown Advisory
Baltimore,
Maryland
|
5,56 Mio. $
|
+223.940 $
|
+11.471
|
+4 %
|
|
|
21
|
Asset Management One
Tokyo,
Japan
|
5,41 Mio. $
|
+419.202 $
|
+21.473
|
+8 %
|
|
|
22
|
Panagora Asset Management
Boston,
Massachusetts
|
4,72 Mio. $
|
+310.522 $
|
+15.906
|
+6 %
|
|
|
23
|
Geode Capital Management
Boston,
Massachusetts
|
3,95 Mio. $
|
+218.630 $
|
+11.199
|
+5 %
|
|
|
24
|
Allianz Asset Management
Munich,
Germany
|
3,88 Mio. $
|
-5,03 Mio. $
|
-257.787
|
-55 %
|
|
|
25
|
Citadel Advisors
Miami,
Florida
|
3,85 Mio. $
|
+3,62 Mio. $
|
+185.564
|
+664 %
|
|
